A5046876145- Cancer Genomics and Diagnostics
- Biosensors and Analytical Detection
- Computational Drug Discovery Methods
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Icing and De-icing Technologies
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Pharmacological Effects of Natural Compounds
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Histone Deacetylase Inhibitors Research
- Polysaccharides and Plant Cell Walls
- Microbial Metabolic Engineering and Bioproduction
- Virus-based gene therapy research
- Plant-derived Lignans Synthesis and Bioactivity
- Calpain Protease Function and Regulation
- Epigenetics and DNA Methylation
- Traditional and Medicinal Uses of Annonaceae
- Sulfur Compounds in Biology
- Traditional Chinese Medicine Analysis
- Biological and pharmacological studies of plants
- Antibiotic Use and Resistance
Guizhou University
2019-2025
Guiyang Medical University
2019-2025
China Academy of Engineering Physics
2024
Hebei North University
2022-2024
National Institute for Communicable Disease Control and Prevention
2024
Lanzhou University
2024
Daping Hospital
2019-2023
Army Medical University
2019-2023
Hebei Medical University
2023
First Affiliated Hospital of Hebei Medical University
2023
Purpose: This study aimed to develop a novel and feasible modification strategy improve the solubility antitumor activity of resiquimod (R848) by utilizing supramolecular effect 2-hydroxypropyl-beta-cyclodextrin (2-HP-β-CD). Methods: R848-loaded PLGA nanoparticles modified with 2-HP-β-CD (CD@R848@NPs) were synthesized using an enhanced emulsification solvent-evaporation technique. The then characterized in vitro several methods, such as scanning electron microscopy (SEM), differential...
Three new trace bisindole alkaloids geleganimines A and B (1, 2) geleganamide (3) were isolated from the aerial parts of Gelsemium elegans. Their structures elucidated by spectroscopy, particularly their carbon–proton coupling constants, electronic circular dichroism. Compounds 1–3 are first discovered genus Gelsemium. Geleganimine exhibited anti-inflammatory activity indirectly suppressing lipopolysaccharide-induced pro-inflammatory factors in BV2 microglial cells with an IC50 value 10.2...
Introduction Stenotrophomonas maltophilia complex (Smc) comprises opportunistic Gram-negative bacilli responsible for various nosocomial infections. Limited data exists concerning its evolutionary lineage, global prevalence and pathogenicity. Methods We conducted an extensive genomic analysis on 734 Smc genomes, of which 90 were newly sequenced isolated from different patients. The species composition relationships examined using core protein sequence analysis. Pathogenicity evaluation was...
Neuronal apoptosis is the main pathological feature of spinal cord injury ( SCI ), while autophagy contributes to ameliorating neuronal damage via inhibition apoptosis. Here, we investigated role tectonic family member 2 TCTN 2) long non‐coding RNA on and in . was down‐regulated tissues a rat model oxygen–glucose deprivation‐induced hypoxic SY ‐ SH ‐5Y cells, microRNA‐216b (miR‐216b) up‐regulated. Overexpression reduced neuron by inducing autophagy, observed negatively regulate miR‐216b....
The genus Paeonia, also known as the "King of Flowers" in China, is an important source traditional Chinese medicine (TCM). Plants this have been used to treat a range cardiovascular and gynecological diseases. However, potential pharmacological activity one particular species, Paeonia rockii, has not fully investigated. In first part present study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS), reducing power assays, metal ion chelating...
Abstract Background Vascular cognitive impairment (VCI) is a common disorder caused by cerebrovascular disease, ranging from mild to dementia. Studies have shown that aerobic exercise might alleviate the pathological development of VCI, and our previous study observed could VCI through NF-κB/miR-503/BDNF pathway. However, there are few studies on mechanism. Therefore, it great significance fill gaps in mechanism for early diagnosis clinical prevention treatment vascular Methods CircRNA...
The COVID-19 pandemic has spread worldwide, and rapid detection of the SARS-CoV-2 virus is crucial for infection surveillance epidemic control. This study developed a centrifugal microfluidics-based multiplex reverse transcription recombinase polymerase amplification (RT-RPA) assay endpoint fluorescence E, N, ORF1ab genes SARS-CoV-2. microscope slide-shaped microfluidic chip could simultaneously accomplish three target one reference human gene (i.e., ACTB) RT-RPA reactions in 30 min,...
A lack of target specificity has greatly hindered the success inhibitor development against matrix metalloproteinases (MMPs) for treatment various cancers. The MMP catalytic domains are highly conserved, whereas hemopexin-like MMPs unique to each family member. domain MMP-9 enhances cancer cell migration through self-interaction and heterointeractions with surface proteins including CD44 α4β1 integrin. These interactions activate EGFR-MAP kinase dependent signaling that leads migration. In...