A5037504766- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- Pain Mechanisms and Treatments
- Skin and Cellular Biology Research
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pulmonary Hypertension Research and Treatments
- Traditional Chinese Medicine Analysis
- Wnt/β-catenin signaling in development and cancer
- Infant Health and Development
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac electrophysiology and arrhythmias
- Mesenchymal stem cell research
- Exercise and Physiological Responses
- Ion Channels and Receptors
- Cardiac Ischemia and Reperfusion
- Estrogen and related hormone effects
- Hair Growth and Disorders
- Wound Healing and Treatments
- Signaling Pathways in Disease
State Key Laboratory of Food Science and Technology
2024
Jiangnan University
2024
Yangzhou University
2024
Shandong Sport University
2021
Sichuan Agricultural University
2021
Zhongnan Hospital of Wuhan University
2020
Wuhan University
2020
Guangzhou University of Chinese Medicine
2020
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2020
Inner Mongolia University
2020
The initiation of breast cancer is associated with increased expression tumor-promoting estrogen receptor α (ERα) protein and decreased tumor-suppressive ERβ protein. However, the mechanism underlying this process unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible overexpressed in cancer, can regulate balance between ERα ERβ. We found modulated many estrogen-responsive genes by enhancing transcriptional activity while inhibiting Consistent regulation activity,...
Bifidobacterium longum S3 influenced the intestinal barrier and immunity, water channel protein expression, neurotransmitter GI active peptide levels by affecting immunity modulating changes in of fatty acid metabolites, especially LCFAs.
Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein that highly expressed in cardiomyocytes. A variety of peptides derived from PEDF exerts diverse physiological activities including anti-angiogenesis, antivasopermeability, and neurotrophic activities. Recent studies demonstrated segmental functional PEDF, 44mer peptide (Val78–Thr121), show similar cytoprotective effect to the holoprotein. We found can reduce infarct size protect cardiac function after acute myocardial...
Background/Aims: Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. However, the role of NLRP1 cardiac hypertrophy remains unclear. We used vivo vitro models to investigate effects on hypertrophy. Methods: NLRP1-deficient mice cultured neonatal rat cardiomyocytes with gain loss function. Cardiac was estimated by echocardiographic hemodynamic measurements, pathological...
Background Pigment epithelium‐derived factor ( PEDF ), which belongs to the noninhibitory serpin family, has shown ability stimulate several physiological processes, such as antiangiogenesis, anti‐inflammation, and antioxidation. In present study, effects of on contractility calcium handling rat ventricular myocytes were investigated. Methods Results Adult Sprague‐Dawley models acute myocardial infarction AMI ) surgically established. ‐lentivirus was delivered into myocardium along away from...
Our previous studies revealed that L-arginine supplementation had beneficial effects on intestinal barrier functions of low-birth-weight (LBW) piglets, which were associated with the enhanced antioxidant capacity. Moreover, mitochondrial are closely related to redox state. This study was explore potential mechanisms L-arginine-induced against dysfunction by regulating function LBW piglets. Twenty 4-day-old normal birth weight (NBW) piglets (BW: 2.08 ± 0.09 kg) and 20 siblings 1.16 0.07...
Diabetic skin defect is difficult to manage in surgical clinics, and there still lack of effective treatments for diabetic defects. Currently, autologous fat grafting (AFG) promising the field reconstructive surgery, while macrophage infiltration adipose tissue considered vital regeneration. But AFG rarely applied treatment defects, whether assists promote wound healing unknown.Full-thickness rats were divided into 3 groups: control group, group with depletion (AFG+MD) group. We examined...
Bone cancer pain is a complex state involving ongoing and movement-related pain, which are thought to be caused by different mechanisms. Transient receptor potential vanilloid subfamily 1 (TRPV1) involved in but not pain. The purpose of this study was investigate the role transient 2 (TRPV2) bone Proportions TRPV1- TRPV2-immunoreactive neurons lumbar dorsal root ganglia innervating femurs male mice were examined using Fluoro-Gold. Mice intrathecally injected with small interfering RNA...
You have accessJournal of UrologyInfertility: Basic Research, Physiology & Pathophysiology1 Apr 2014MP66-13 14-3-3 EPSILON MAY PLAY AN IMPORTANT ROLE IN TESTICULAR GERM CELL APOPTOSIS: A FUNCTIONAL PROTEOMIC STUDIES OF EXPERIMENTAL VARICOCELE Yan Zhang, Zhongmin Yuan, Qingqing He, Hao Xiaopeng Liu, Jinming Di, Liaoyuan Li, Xiaojian Yang, and Xin Gao ZhangYan Zhang More articles by this author , YuanZhongmin Yuan HeQingqing He ZhangHao LiuXiaopeng Liu DiJinming Di LiLiaoyuan Li YangXiaojian...
Objectives: Evidence from epidemiologic studies has been inconsistent regarding the role of vitamin E in cancer incident risk. We aimed to investigate prospective association between baseline plasma levels and risk, identify effect modifiers. Methods: employed a nested case-control design, using data China Stroke Primary Prevention Trial (CSPPT), including 229 patients with matched controls. Results: The median follow-up duration was 4.5 years. Overall, not associated subsequent risk total...
Abstract Background: Atherosclerosis is a major pathogenic factor in cardiovascular diseases during the aging process. Foam cell formation and endothelial dysfunction play key role initiation development of atherosclerosis, which are affected by lipid disorder inflammation. Therefore, drug for inhibition subsequent foam therapeutic approach atherosclerosis treatment. Total flavone Astragalus membranaceus (TFA) extracted from that has protective effect on disease. However, TFA underlying...
PURPOSE: Determine the effect of hydroxytyrosol on NAFLD, and study whether aerobic exercise can enhance its intervention NAFLD. METHODS: NAFLD mice were induced by a high-fat diet divided into five groups: Control (Co), model (Na), Hydroxytyrosol (HNa), combined with 60%VO2max (HENa), GLSP (GNa). Mice in each group given corresponding solutions (Hydroxytyrosol 1.5 mg/ml, 4.17 mg/ml) gavage at 20 mL/kg. HENa performed moderate intensity (60%VO2max). The slope treadmill was 15 degrees, scheme...