A5100321252- Spine and Intervertebral Disc Pathology
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Antimicrobial Peptides and Activities
- Electrocatalysts for Energy Conversion
- Diet and metabolism studies
- Sulfur Compounds in Biology
- Angiogenesis and VEGF in Cancer
- Tendon Structure and Treatment
- Cancer, Hypoxia, and Metabolism
- Antimicrobial agents and applications
- Musculoskeletal pain and rehabilitation
- Cancer, Lipids, and Metabolism
- Shoulder Injury and Treatment
- Spinal Fractures and Fixation Techniques
- Sports injuries and prevention
- Cardiac Ischemia and Reperfusion
- Advanced Photocatalysis Techniques
- Atherosclerosis and Cardiovascular Diseases
- Advanced battery technologies research
- Animal Vocal Communication and Behavior
Soochow University
2015-2025
Hangzhou Medical College
2024-2025
Zhejiang Provincial People's Hospital
2024-2025
Gansu University of Traditional Chinese Medicine
2025
First People's Hospital of Chongqing
2024
International Peace Maternity & Child Health Hospital
2024
Shanghai Jiao Tong University
2024
Union Hospital
2019-2023
Huazhong University of Science and Technology
2023
China Animal Disease Control Center
2023
Abstract Extracting species calls from passive acoustic recordings is a common preliminary step to ecological analysis. For many species, particularly those occupying noisy, acoustically variable habitats, the call extraction process continues be largely manual, time‐consuming and increasingly unsustainable process. Deep neural networks have been shown offer excellent performance across range of classification applications, but are relatively underused in ecology. We describe steps involved...
We examined the possible role of hydrogen sulfide (H2S) in pathogenesis oleic acid (OA)-induced acute lung injury (ALI) and its regulatory effects on inflammatory response. Compared to control rats, OA-treated rats had decreased partial pressure oxygen arterial blood (PaO2) levels, an increased pulmonary wet/dry weight (W/D) ratio, index quantitative assessment (IQA) score frequency polymorphonuclear (PMN) cells 2, 4 or 6 h after OA injection (0.1 ml/kg, intravenous injection). In addition,...
Nitrogen (N) is associated with amino acid metabolism in higher plants. Theanine an important tea To explore the relationship between theanine and N conditions, we examined differentially expressed genes (DEGs), proteins (DEPs), microRNAs (DEMs) involved plant shoots roots under sufficiency deficiency conditions. Transcriptome, proteome, microRNA analyses were performed on The contents of theanine, expression levels metabolism, proteinogenic acids, activity enzymes analyzed. DEP-DEG...
The occurrence and development of acute lung injury (ALI) involve a variety pathological factors complex mechanisms.How pulmonary cells communicate with each other subsequently trigger an inflammatory cascade remains elusive.Extracellular vesicles (EVs) are critical class membrane-bound structures that have been widely investigated for their roles in pathophysiological processes, especially immune responses tumor progression.Most the current knowledge functions EVs is related to derived from...
Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it is unclear whether cyanidin prevents the progression of intervertebral disc degeneration (IVDD).This study evaluates effects on IVDD vitro and vivo.Nucleus pulposus cells (NPCs) isolated from lumbar IVD 4-week-old male Sprague-Dawley (SD) rats were exposed 20 ng/mL IL-1β, then treated with different doses (0-120 µM) for 24 h. SD classified into three groups (n = 8) as follows: control (normal saline),...
Abstract Robust rhythms of abundances and phosphorylation profiles PERIOD proteins were thought be the master that drive mammalian circadian clock functions. PER stability was proposed to a major determinant period length. In mammals, CK1 forms stable complexes with PER. Here we identify residues essential for PER-CK1 interaction. cells in mice, their mutation abolishes CLOCK hyperphosphorylation, resulting stabilization, arrhythmic abundance impaired negative feedback process, indicating...
The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome has been linked to sterile inflammation, which is involved in ischemic injury myocardial cells. Pigment epithelium-derived factor (PEDF) a multifunctional secreted glycoprotein with many biological activities, such as anti-inflammatory, antioxidant and anti-angiogenic properties. However, it not known whether how PEDF acts regulate the activation of NLRP3 cardiomyocytes. In present study, we used...
Esophageal squamous cell carcinoma is the most common type of esophageal cancer and accounts for 5% malignant tumor deaths. Recent research suggests that chronic inflammation DNA damage may drive onset carcinoma, implying lowering compounds provide chemo-prevention. According to epidemiological experimental evidence, selenium linked a lower risk several malignancies, including carcinoma. However, its exact mechanism still unclear. In present study, we used lines 4-NQO mice model explore...
Abstract The electrochemical two‐electron oxygen reduction reaction (2e − ORR) offers a sustainable pathway for the production of H 2 O ; however, development electrocatalysts with exceptional activity, selectivity, and long‐term stability remains challenging task. Herein, novel approach is presented to addressing this challenge by synthesizing hierarchical hollow SmPO 4 nanospheres open channels via two‐step hydrothermal treatment. produced compound demonstrates remarkable 2e exceeding 93%...
Abstract Background The factors influencing the onset of new atrial fibrillation following Morrow procedure due to cardiopulmonary bypass (CPB) are unclear. This study investigated CPB-related associated with postoperative (POAF) in patients undergoing minimally invasive ventricular septal myectomy (Morrow procedure) optimize CPB strategies, reduce incidence POAF, and enhance recovery. Methods A retrospective clinical data analysis was conducted on 139 who underwent procedures from January...
Radiotherapy is a major treatment option for non-small cell lung cancer (NSCLC); however, irradiated tumor cells can damage non-irradiated through radiation-induced bystander effects (RIBE), which affect the therapeutic efficacy. The study aimed to investigate mechanism underlying RIBE and protective of vanillic acid (VA) on human bone marrow mesenchymal stem (BMSCs). We established two irradiation models RIBE. First, we A549 model alone, tested expression cathepsin B (CTSB) transforming...
The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part coronary heart disease surgery becoming a major clinical problem in the treatment ischemic disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac function rats with acute infarction reduces hypoxia‑induced cell injury. However, protective mechanisms underlying effect PEDF MI/R remain to be fully understood. In present study,...
Many animals display morning and evening bimodal activities in the day/night cycle. However, little is known regarding potential components involved regulation of behavioral rhythms mammals. Here, we identified that zinc finger protein gene Zbtb20 plays a crucial role mice. Depletion nerve system resulted loss early activity, but increase activity. We found Zbtb20-deficient mice exhibited pronounced decrease expression Prokr2 resembled phenotypes Prok2 Prokr2-knockout Injection...
Surface modification with cationic polymer coatings represented an important strategy to address the medical device-related infection issues. However, limited antibacterial activities and high cytotoxicity have hampered their development. Herein, we report a facile method enhance surface activity by construction of imidazolium-based polypeptide fosfomycin counteranions (i.e., S4-PIL-FS). The coating displayed synergistic effect from combination membrane disruption inhibition initial cell...
Polymer coatings with improved surface antibacterial properties are of great importance for the application and development implantable medical devices. Herein, we report design, preparation, a series brush polymers (Dex-KEs) hydrophilic dextran main-chains mixed-charge polypeptide (KE) side-chains. Dex-KEs showed higher bactericidal activity antifouling antibiofilm than maleic acid modified (Dex-Ma), KE, Dex-Ma/KE blend coatings, polymer hydrophobic (AcDex-KEs). They also negligible in...
NSD3 is a histone lysine methyltransferase that methylates H3 at 36. located chromosome 8p11.23, the locus exhibits strong cancer relevance. Thus, likely involved in multiple human cancers. Nevertheless, its roles carcinogenesis remain unknown. In present study, we demonstrated silencing of osteosarcoma, most common primary bone children and adolescents, results marked decrease number viable cells, accompanied by increases cell population G2/M phase apoptotic cells. addition, 549...