A5041627142- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Semiconductor Lasers and Optical Devices
- Metabolism, Diabetes, and Cancer
- Microwave Engineering and Waveguides
- Neurological Disorders and Treatments
- Tendon Structure and Treatment
- Regional Economic and Spatial Analysis
- Parkinson's Disease Mechanisms and Treatments
- Shoulder and Clavicle Injuries
- Plant Toxicity and Pharmacological Properties
- Reconstructive Surgery and Microvascular Techniques
- Electrical and Thermal Properties of Materials
- Apelin-related biomedical research
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Natural Compounds in Disease Treatment
- Spinal Hematomas and Complications
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Inflammatory mediators and NSAID effects
- Bioactive Natural Diterpenoids Research
- Pelvic and Acetabular Injuries
Second Hospital of Shandong University
2024
Xuzhou University of Technology
2024
Xidian University
2023-2024
Baoding No.1 Central Hospital
2019-2023
Baoding People's Hospital
2019-2023
Third Hospital of Hebei Medical University
2019-2022
Hebei Medical University
2019-2022
Tianjin Hospital
2021
Hebei North University
2017
Soochow University
2009
Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it is unclear whether cyanidin prevents the progression of intervertebral disc degeneration (IVDD).This study evaluates effects on IVDD vitro and vivo.Nucleus pulposus cells (NPCs) isolated from lumbar IVD 4-week-old male Sprague-Dawley (SD) rats were exposed 20 ng/mL IL-1β, then treated with different doses (0-120 µM) for 24 h. SD classified into three groups (n = 8) as follows: control (normal saline),...
Intervertebral disc degeneration (IDD) is a complex degradative disorder associated with inflammation. Emodin, an anthraquinone derivative, possesses strong anti-inflammatory activity. This study focused on the in vitro therapeutic action of emodin cellular model IDD. Human nucleus pulposus cells (NPCs) were stimulated interleukin-1β (IL-1β) to induce Cell Counting Kit-8 and terminal deoxynucleotidyl transferase dUTP nick end labeling staining assays performed evaluate viability apoptosis...
Intervertebral disc degeneration (IDD) is a natural progression of the aging process associated with inflammation. Higenamine, plant-based alkaloid, has been identified to possess various pharmacological properties, including anti-inflammatory activity. In present study, we aimed evaluate role higenamine in interleukin (IL)-1β-induced inflammation human nucleus pulposus cells (NPCs). The results showed that improved cell viability IL-1β-induced NPCs. IL-1β-dependent up-regulation...
Background and Objective: Diabetes mellitus (DM) is reportedly a significant risk factor for intervertebral disc degeneration (IDD). Incretin system particularly glucagon-like peptide 1 (GLP-1) because of its glucose-lowering effects has become an important target in therapeutic strategies type 2 diabetes (T2D). Liraglutide GLP-1 receptor (GLP-1R) agonist with glucoregulatory insulinotropic functions as well regulatory on cell proliferation, differentiation, apoptosis. However, little known...
To explore the effect of baicalin on human nucleus pulposus cells (NPCs) in response to interleukin (IL)-1β stimulation.Viability NPCs was measured by cell counting kit-8 (CCK-8) assay. TUNEL staining assay and flow cytometry were performed detect apoptotic death NPCs. Western blot analysis conducted expression levels proteins. Enzyme-linked immunosorbent (ELISA) applied for determination inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α),...
Abstract Diabetes mellitus (DM) is a potential etiology of disc degeneration. Glucagon-like peptide-1 (GLP-1) currently regarded as powerful treatment option for type 2 diabetes. Apart from the beneficial effects on glycaemic control, GLP-1 has been reported to exert functions in variety tissues modulation cell proliferation, differentiation, and apoptosis. However, little known regarding nucleus pulposus cells (NPCs). In present study, we investigated liraglutide (LIR), long-lasting...
Nucleus pulposus (NP) apoptosis is mainly charged for the pathological process of Intervertebral disc degeneration (IVDD). Our previous study revealed that Resveratrol (RSV) combined with 17β-estradiol (E2) was more effective in cutting down IL-1β induced NP cell via PI3K/AKT pathway. The present further evaluated effect RSV and E2 anti-apoptosis IVDD.Human nucleus cells culture system inducing model were constructed this research. used to inhibit apoptosis. FACS (Fluorescence-activated...
Abstract Cyanidin‐3‐glucoside (C3G) is a well‐known natural anthocyanin with antioxidant and anti‐inflammatory properties. In this study, we explored the role action mechanism of C3G in high glucose (HG)‐induced damage human nucleus pulposus cells (HNPCs). Cell viability was assessed by CCK‐8 assay. TUNEL assay performed for detecting apoptotic rate. Western blot to determine expression levels cl‐caspase‐3, caspase‐3, Bax, Bim, collagen II, aggrecan, MMP‐3, MMP‐13, ADAMTS5. Reactive oxygen...
Abstract Objective: The purpose of the present study was to investigate specific downstream signaling pathway mediated by PI3K/Akt in resveratrol (RES) anti-apoptosis nucleus pulposus cells (NPCs). Materials and methods: Human NPCs were cultured divided into six groups. Interleukin (IL)-1β used induce apoptosis RES inhibit apoptosis. Fluorescence-activated cell sorting (FACS) analysis test apoptotic incidence NPCs, counting kit-8 (CCK-8) assay performed detect viability, expression level...
In this paper, a two-stage cascaded broadband low-temperature and low-noise amplifier is designed based on the enhanced pseudo-electron mobility transistor (E-pHEMT) ATF54143 with an operating frequency range from 4 GHz to 6 GHz. The π-type matching, T-type matching parallel resistor negative feedback are adopted achieve bandwidth of 2 final simulation results show that gain 25.8±3.65 dB at low temperature 20 K, noise figure 0.1015±0.0145, input output reflection coefficients below -10 in...
目的 探讨高位旋转点的腓动脉穿支蒂皮瓣修复跟骨骨折术后钢板外露的可行性及临床疗效。 方法 回顾性分析2010年5月—2013年8月保定市第一中心医院骨科收治的21例跟骨骨折术后出现钢板及跟骨外露患者的临床资料。21例患者均行腓动脉穿支蒂皮瓣修复创面，皮瓣旋转点选择外踝上7～9 cm处的腓动脉外踝上第2穿支，术后观察皮瓣成活率及皮瓣感觉恢复情况。 结果 21例患者手术均顺利完成，皮瓣均成活。全组患者随访6～12个月(平均9.1个月)，皮瓣血运良好，质地柔软、耐磨，伤口一期愈合，无骨感染发生。其中12例皮瓣经过二期修整后外形美观，满足穿鞋等要求，感觉恢复达S2级；3例行腓肠外侧皮神经移位的患者，皮瓣感觉恢复达S3级，但无明确的两点分辨觉。 结论 高位旋转点的腓动脉穿支蒂皮瓣可用于修复跟骨骨折术后钢板外露创面，其手术方式安全、可靠，皮瓣修薄后外形美观，适合穿鞋袜等日常要求，可一定程度恢复浅感觉。
In this paper, a high-performance miniature bandpass filter with controllable transmission zeros is designed using low temperature co-fired ceramic (LTCC) process for the metrics and miniaturisation requirements of C-band receiver front-end filter. The overall design adopts form lumped parameter, introducing on both sides passband through LC blocking band-trapped resonance to improve out-of-band rejection, adjusting position by size capacitance. modelled simulated in HFSS, Simulation results...
Objective To study the distribution of supraclavicular nerve in region and provide reference for operation. Methods Prospective study. From September 2017 to December 2018, 30 patients with clavicle fractures, including 16 males 14 females, aged from 18 46 years old, had completed anatomy Surgery Fracture Reduction Internal fixation Fifth Department Orthopaedic, First Central Hospital Baoding City. The incisions were taken all patients(30 sides), branches nerves carefully separated...