A5005672969- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Carcinogens and Genotoxicity Assessment
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Kruppel-like factors research
- Acute Ischemic Stroke Management
- Wnt/β-catenin signaling in development and cancer
- Genetic Associations and Epidemiology
- Air Quality and Health Impacts
- Genetic Syndromes and Imprinting
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Energy and Environment Impacts
- Virus-based gene therapy research
- Endoplasmic Reticulum Stress and Disease
- Kidney Stones and Urolithiasis Treatments
- Electrostatic Discharge in Electronics
Nanjing Medical University
2012-2024
Jiangsu Province Hospital
2015-2024
Yangzhou University
2024
Harbin Engineering University
2023
Linzi District People's Hospital
2019
Background Enhanced motility of cancer cells is a critical step in promoting tumor metastasis. Lysophosphatidic acid (LPA), representing the major mitogenic activity serum, stimulates migration various types cells. However, underlying signaling mechanisms for LPA-induced remain to be elucidated. Methodology/Principal Findings In this study, we found that LPA dose-dependently stimulated MDA-MB-231 breast cells, with 10 µM being most effective. also increased ERK and MEK inhibitor U0126 could...
The effect of the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) on clinical outcomes acute ischaemic stroke (AIS) patients is unclear. This study sought determine whether TG/HDL-C in AIS associated with worse at 3 months.Acute who were admitted from 2011 2014 enrolled this study. TG, total (TC), HDL-C and low-density (LDL-C) collected admission. Three end-points defined according modified Rankin scale (mRS) score months after symptom onset (excellent...
Acute cerebral infarction threats human health and life safety. The edaravone is a new antioxidant hydroxyl radical scavenger, which the novel scavenger for clinical use, mainly nervous system diseases.The purpose of this study to observe treatment effects on degree improvement neurological impairment functional movement in patients with acute infarction.A total 130 admitted our hospital because from December 2015 May 2017 were selected group analysis. These divided into control (n = 65)...
Abstract Background N6-methyladenosine (m6A) modification plays an important role in lung cancer. However, methyltransferase-like 14 (METTL14), which serves as the main component of m6A complex, has been less reported to be involved immune microenvironment This study aimed analyze relationship between METTL14 and checkpoint inhibitor programmed death receptor 1 (PD-1) Methods CCK-8, colony formation, transwell, wound healing, flow cytometry assays were performed explore cancer progression...
Adenocarcinoma (AC) and squamous cell carcinoma (SqCC) are two major histological subtypes of lung cancer. Genome-wide association studies (GWAS) have made considerable advances in the understanding cancer susceptibility. Obvious heterogeneity has been observed between different cancer, but genetic determinants specific to SqCC not systematically investigated. Here, we performed GWAS analysis specifically for 833 cases 3,094 controls followed by a two-stage replication additional 2,223 6,409...
Long noncoding RNAs (lncRNAs), genomic "dark matter," are deeply involved in diverse biological processes. The lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is a highly participatory lncRNA; however, its roles gastric cancer (GC) remain largely unexplored. Here, we demonstrated that the expression of NEAT1 was significantly increased and negatively correlated with prognosis GC. Subsequent experiments confirmed KLF5 can induce by binding to promoter region. Further revealed...
Lung cancer is the leading cause of cancer-related deaths worldwide. By now, genome-wide association studies (GWAS) have identified numerous loci associated with risk developing lung cancer. However, these account for only a small fraction familial risk. We hypothesized that epistasis may contribute to missing heritability. To test this hypothesis, we systematically evaluated genetic variants in Han Chinese cohorts. conducted pairwise interaction analysis 591370 variants, using BOolean...
Ischemia causes desquamation of proximal tubular epithelial cells leading to acute renal failure. However, the molecular mechanisms underlying detachment tubule remain unknown. In this study, we reported that ATP depletion resulted in actin polymerization, a shift filamentous from web-like structure fragmented parallel stress fibers, followed by reduction cellular adhesion ability. The pre-treatment with Jasplakinolide, an stabilizer, prevented depletion-induced polymerization and cell...
Pneumoconiosis is the most serious occupational disease in China and its leading cause silica exposure. takes several years to develop depending on exposure level of silica. However, individual variation susceptibility pneumoconiosis has been observed among subjects with similar We conducted a genome-wide screening 710 999 single nucleotide polymorphisms (SNPs) cohort 400 coal workers (202 cases 198 exposed controls) for susceptible loci. Seven promising variants were evaluated an...
This study aimed to investigate whether computed tomography (CT)-measured erector spinae parameters (ESPs) have diagnostic, severity assessment, and prognostic predictive value in uremic sarcopenia (US).
Background: It has been reported that long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis. However, their ovarian cancer (OC) remain to be elucidated. The aim of this study was uncover the function and underlying mechanisms PCAT6 OC. Methods: expression pattern OC analyzed GSE137238, GSE143897 Gene Expression Profile Interactive Analysis (GEPIA) datasets. Kaplan–Meier Plotter online software used for survival analysis. Loss-of-function assays gain-of-function were assess...
Cell cycle regulation, apoptosis, oxidative stress and inflammation response play critical roles in the development of smoking-induced lung cancer. However, it is still not well known whether their genetic variants are associated with cancer susceptibility. In this study, we performed imputation-based association analyses to investigate influence common these pathways interactions smoking on We first selected 24 042 unvalidated 798 genes from imputed dataset previous genome-wide study 2331...
The pathogenesis of infective endocarditis (IE) is a complex process which can include tissue damage to the valves during bacteraemia, pathogen adherence leading formation non-bacterial thrombotic vegetations, platelet aggregation at sites damage, and variety biological interactions between pathogens host matrix molecules (e.g. platelets).1,2 In past few decades, incidence IE has increased significantly, may be result an aging population, delayed diagnosis valvular heart disease, even new...