A5044367147- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Spinal Cord Injury Research
- Inflammatory mediators and NSAID effects
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Maternal and Perinatal Health Interventions
- Organ Transplantation Techniques and Outcomes
- Neuropeptides and Animal Physiology
- Rheumatoid Arthritis Research and Therapies
- Organ and Tissue Transplantation Research
- Neutropenia and Cancer Infections
- Thermal Regulation in Medicine
- Pediatric health and respiratory diseases
- Gout, Hyperuricemia, Uric Acid
- Pregnancy and preeclampsia studies
- Hemostasis and retained surgical items
- Healthcare Systems and Public Health
- Microbial Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Spinal Dysraphism and Malformations
Shanghai Traditional Chinese Medicine Hospital
2021-2022
Nanjing Maternity and Child Health Care Hospital
2018-2021
Nanjing Medical University
2018-2021
Nanjing University of Chinese Medicine
2019-2021
Genesee Community College
2020
Cancer Institute (WIA)
2017
Wuhan Polytechnic University
2017
Fudan University Shanghai Cancer Center
2017
Shanghai Medical College of Fudan University
2017
Xiangnan University
2002
The present study aimed to explore the association of long non-coding RNA nuclear-enriched abundant transcript 1 (lnc-NEAT1) with inflammation, disease activity, treatment outcome, and its targets (microRNA [miR]-21 miR-125a) in patients rheumatoid arthritis (RA).Peripheral blood mononuclear cells were sampled from 130 RA at baseline, week (W) 6, W12, as well 60 healthy controls (HCs) after enrollment. Meanwhile, expressions lnc-NEAT1, miR-21, miR-125a detected by reverse...
Bone marrow mesenchymal stem cell (BMMSC) is reported to promote spinal cord injury (SCI) recovery via secreting exosomes deliver RNAs, proteins, lipids, etc. The present study aimed investigate the effect of microRNA 137 (miR-137)-overexpressing BMMSC on SCI rats. BMMSCs were extracted from Sprague-Dawley (SD) rat hind leg bone marrow, and then BMMSC-secreted collected. MiR-137 mimic negative control (NC) transfected into BMMSCs, corresponding Subsequently, SD rats treated with sham...
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic diseases worldwide. Recent studies have indicated that fish oil supplementation has benefits against NAFLD. Our previous transcriptomic study validated effect on altering hepatic gene expression in a NAFLD rat model. In current study, we examined effects microRNAs. Male Sprague–Dawley rats were fed with lab chow (CON), high-fat high-cholesterol diet (WD), or WD supplemented (FOH), respectively. Small RNAs extracted...
Background: Chronic hypertension during pregnancy is a significant concern, associated with increased risks of maternal-fetal morbidity and mortality. Epigallocatechin gallate (EGCG), compound known for its cardioprotective properties, has gained attention as potential health supplement due to favorable safety profile. Objective: This study aims investigate the effects maternal EGCG supplementation on elevated blood pressure outcomes in rodent model chronic hypertension, specifically using...
Bladder cancer (BC) is one of the most frequent urologic tumors worldwide. However, long non-coding RNA(lncRNA) expression profiles in BC progression remain unclear. This study aimed to explore lncRNA different grades bladder and normal urothelium tissues.We performed high-throughput sequencing tissues grade obtained its lncRNAs. Then, aberrantly expressed lncRNAs were validated by quantitative reverse transcription polymerase chain reaction (RT-PCR). Gene Ontology (GO) pathway analyses used...
Background: It has been reported that long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis. However, their ovarian cancer (OC) remain to be elucidated. The aim of this study was uncover the function and underlying mechanisms PCAT6 OC. Methods: expression pattern OC analyzed GSE137238, GSE143897 Gene Expression Profile Interactive Analysis (GEPIA) datasets. Kaplan–Meier Plotter online software used for survival analysis. Loss-of-function assays gain-of-function were assess...
Abstract Background: Topical hemostatic agents are commonly used for reducing perioperative blood loss and transfusion requirement in primary total knee arthroplasty (TKA), although the optimal option has yet to be defined. This study aimed evaluate efficacy safety of topical rank best intervention using network meta-analysis (NMA) method. Methods: We searched Web science, PubMed, Cochrane Library database up April 2020, randomized controlled trials (RCTs) on TKA. The quality included...
ABSTRACT Objective This study aimed to investigate the linkage of long non-coding RNA (lncRNA) expression profile with etanercept response in rheumatoid arthritis (RA) patients. Methods Peripheral blood mononuclear cell (PBMC) samples were collected from 80 RA patients prior treatment. Samples eight responders and non-responders at week 24 (W24) proposed RNA-sequencing, then 10 candidate lncRNAs sorted their PBMC expressions validated by reverse transcription quantitative chain reaction...
With the advancement of next generation sequencing in past several years, a rising number non-coding RNAs have been found as new actors to regulate gene expression. Non-coding not only play important roles carcinogenesis, but also affect clinical treatment strategies. They proved be deeply correlated with chemoresistance cancers. Ovarian cancer is leading cause death gynecological malignancy, low 5-year survival rate. Most patients are identified when they late-stage disease. This review...
Abstract Background 20–40% of lung cancer patients develop bone metastasis (BM) with significantly decreased overall survival. Currently, BM is mainly diagnosed by CT scan or MRI when symptom develops. Novel biomarkers higher prediction value are needed. Methods Prospective analysis was undertaken on non-small cell (NSCLC) (BM+) and without (BM-). Plasma exosomal RNA isolated sequenced from peripheral blood patients. Differential expression weighted gene co-expression networks (WGCNA) mi-RNA...