A5100752807- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- High Altitude and Hypoxia
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Sleep and related disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Hybrid Renewable Energy Systems
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet, Metabolism, and Disease
- Adsorption and biosorption for pollutant removal
- Hypothalamic control of reproductive hormones
- Chromatography in Natural Products
- Neurotransmitter Receptor Influence on Behavior
Hebei Medical University
2016-2025
Nanjing Medical University
2019-2025
Jiangsu Province Hospital
2025
East China University of Science and Technology
2024-2025
Dongyang People's Hospital
2025
Wenzhou Medical University
2025
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shanxi University of Traditional Chinese Medicine
2018-2021
Tianjin Medical University General Hospital
2020
Sniffing is a specialized respiratory behavior that enables rodents to localize and track objects in their environment. The organum vasculosum of the lamina terminalis (OVLT) critically involved regulation thirst water intake, yet its role controlling thirst-driven exploratory sniffing behaviors remains unclear. This study demonstrates hypertonic stimulation significantly increases activates OVLT glutamatergic (OVLTGlut) neurons. Photostimulation both OVLTGlut neurons axon terminals within...
The present study was designed to investigate further the effects of newly discovered orphanin FQ (OFQ)‐the endogenous ligand for orphan opioid receptor (called, e.g., ORL 1 and LC132)‐on pain modulation in rat. We used tail‐flick assay as a nociceptive index. When injected into cerebral ventricle, OFQ (4 fmol‐10 nmol) has no effect on basal latency by itself at any dose, but dose‐dependently antagonizes systemic morphine analgesia (400 fmol‐50 nmol). Injected intrathecally, (3 10 displayed...
Leptin can exert its potent appetite-suppressing effects via activation of hypothalamic proopiomelanocortin (POMC) neurons. It depolarizes POMC neurons a yet unidentified nonselective cation current. Therefore, we sought to identify the conductance activated by leptin using whole-cell recording in EGFP-POMC from transgenic mice. The TRPC channel blockers SKF96365 (1-[β-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1 H -imidazole hydrochloride), flufenamic acid, and 2-APB (2-aminoethyl...
Abstract Background Increased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both human and animal studies suggests a link between hypertension gut microbiota, as well microbiota-derived metabolites short-chain fatty acids (SCFAs). However, the precise mechanisms underlying this gut-brain axis remain unclear. Methods The levels of SCFAs spontaneously hypertensive rats (SHRs) were determined by gas chromatography-mass...
Abstract Gas–liquid two‐phase flow in alkaline water electrolysis critically influences current density and efficiency, yet quantitative insights remain limited. This work examines gas holdup bubble size distribution a custom‐designed 1.5‐m high‐electrolytic cell, mimicking an industrial press‐filter design. Results reveal that increases with cell height due to cumulative production, while higher electrolyte velocity reduces by accelerating transport. The average electrolytic d 43 evolves...
The dynamic interaction between central respiratory chemoreceptors and the pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm pattern, yet its circuit-level organization remains poorly characterized. Here, functional connectivity two key medullary hubs: nucleus tractus solitarius (NTS) preBötzinger complex (preBötC) are systematically investigated. These findings delineate network primarily comprising Phox2b-expressing NTS neurons (NTSPhox2b),...
Entacapone has been widely used in the treatment of moderate to advanced Parkinson's disease (PD), and its efficacy for motor symptoms well-known from several clinical trials long-term use. The Levodopa/Carbidopa/Entacapone (LCE) on neuropsychological functions PD not validated yet, little is known about effect LCE peripheral inflammatory cytokines. aim this study was investigate explore relationship with changes cytokine levels. All patients were randomly assigned experimental group...
The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but neuronal phenotype and circuit mechanism involved such a physiological function remain incompletely understood. This study focused on respiratory role paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons sought to determine whether selective stimulation this set activates breathing male mice. A Cre-dependent vector encoding Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into...
To explore the immunological mechanisms underlying effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat.Fifty-four adult male Sprague-Dawley rats were used experiment. Arthritis CIA (n=18) was induced by injection collagen. The CIHH+CIA treated with CIHH (simulated 3000 m altitude, 5 hours per day for 28 days, PO2=108.8 mmHg) before CIA. control not given any treatment.(1) Incidence rate significantly lower than that (P<0.05). (2)...
The petroleum ether fraction of Bupleuri Radix which is contained in the traditional Chinese medicine prescription Xiaoyaosan (XYS) may have a therapeutic effect depressed subjects based on results our previous study. It has been reported that can cause liver toxicity following overdosing or long-term use. Therefore, this study aimed to decipher differential effective and toxic responses chronic unpredictable mild stress (CUMS) (with depression) healthy rats serum metabolic profiles. Serum...
Abstract Objective Phenylethanolamine N ‐methyltransferase (PNMT)‐expressing neurons in the nucleus tractus solitarii (NTS) contribute to regulation of autonomic functions. However, neural circuits linking these other brain regions remain unclear. This study aims investigate connectivity mechanisms PNMT‐expressing NTS (NTS PNMT neurons). Methods The methodologies employed this included a modified rabies virus‐based retrograde tracing technique, conventional viral anterograde tracing, and...
The nucleus tractus solitarii (NTS) plays a critical role in the homeostatic regulation of respiration, blood pressure, sodium consumption and metabolic processes. Despite their significance, circuitry mechanisms facilitating these diverse physiological functions remain incompletely understood. In this study, we present whole-brain mapping both afferent efferent connections Phox2b-expressing GABAergic neurons within NTS. Our findings reveal that neuronal populations not only receive...
Abstract The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in autonomic regulation cardiovascular activity. Phenotypically-characterized NTS neurons have been implicated differential blood pressure (BP). Here, we investigated whether phenylethanolamine N-methyltransferase (PNMT)-expressing (NTS PNMT ) contribute to control BP. We demonstrate photostimulation has variable effects on A depressor response was produced during...
Previous studies have confirmed that tea polyphenols possess a broad spectrum of biological functions such as anti-oxidative, anti-bacterial, anti-tumor, anti-inflammatory, anti-viral and cardiovascular protection activities, well anti-cerebral ischemia-reperfusion injury properties. But the effect on ischemia/reperfusion heart has not been elucidated. The aim this study was to investigate protective theaflavin (TF1) its underlying mechanism. Young male Sprague-Dawley (SD) rats were randomly...
Leptin is an adipose-derived hormone that plays important role in the regulation of breathing. It has been demonstrated obesity-related hypoventilation or apnea closely associated with leptin signaling pathways. Perturbations probably contribute to reduced sensitivity respiratory chemoreceptors hypoxia/hypercapnia. However, underlying mechanism remains incompletely understood. The present study test hypothesis contributes modulating a hypoxic ventilatory response. function was assessed...
The nucleus tractus solitarii (NTS) is the primary central station that integrates visceral afferent information and regulates respiratory, gastrointestinal, cardiovascular, other physiological functions. Leptin receptor b (LepRb)-expressing neurons of NTS (NTSLepRb neurons) are implicated in respiration regulation, respiratory facilitation, drive enhancement. Furthermore, LepRb dysfunction involved obesity, insulin resistance, sleep-disordered breathing. However, monosynaptic inputs outputs...