A5029081799- Immune Cell Function and Interaction
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Cell Adhesion Molecules Research
- Medical and Biological Sciences
- Biomarkers in Disease Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Salivary Gland Tumors Diagnosis and Treatment
- Lymphatic System and Diseases
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Ocular Surface and Contact Lens
- Peripheral Neuropathies and Disorders
- Case Reports on Hematomas
- Psoriasis: Treatment and Pathogenesis
- Glycosylation and Glycoproteins Research
Zhejiang Hospital
2018-2024
Zhejiang University
2022
Second Affiliated Hospital of Zhejiang University
2018-2021
Weatherford College
2020
To compare clinical characteristics and identify long-term outcomes of Chinese patients with systemic sclerosis (SSc) without muscle involvement.We retrospectively investigated the medical records, laboratory results, computed tomography images 204 consecutive SSc patients. Kaplan-Meier analysis was performed to determine survival rates. Patients were allocated into groups myopathy.The prevalence myopathy 21.6%. The group more likely develop diffuse cutaneous involvement (90.9% vs 56%, P =...
To determine the prevalence of hypocomplementemia in primary Sjogren's syndrome (pSS) patients and compare clinical characteristics with without hypocomplementemia.A retrospective study was conducted 120 treatment-naive Chinese that met 2012 American College Rheumatology Classification Criteria for pSS were followed up 3 to 24 months. Based on complement results, divided into four groups: only low C3, C4, both C3 C4 (double low), normal group. The data patient demographics, manifestations,...
Objectives. This study aimed to investigate the clinical characteristics and risk factors of fever in hospitalised patients with acute gouty arthritis (AGA). Methods. The data 167 AGA who met inclusion criteria were retrospectively analysed. demographic, clinical, medication without compared, associated identified via logistic regression analysis. Results. incidence was 31.1%, low-grade being predominant. Visual analogue scale (VAS) scores, white blood cell counts, neutrophil proportion,...
To assess the efficacy of methotrexate (MTX) and hydroxychloroquine (HCQ) in improving fatigue symptoms patients with primary Sjögren's syndrome (pSS).
Objective: To investigate the clinical significance of soluble Semaphorin 5A(Sema 5A) in patients rheumatoid arthritis(RA) and effect Sema 5A on osteoclastogenesis RAW264.7 cells. Methods: (1)Soluble was detected serum 62 RA patients, 30 osteoarthritis(OA) 48 healthy controls(HC) by enzyme-linked immunosorbent assay(ELISA).The relationships between disease activity, radiographic severity laboratory parameters were investigated patients.(2)RAW264.7 cells treated with different concentrations...
<h3>Background</h3> LILRA3 is a member of the LILR family produced as soluble molecule by monocytes and macrophages. A 6.7-kb deletion in gene results null allele an absence function. The frequencies vary greatly different populations, considerably higher Northeastern Asians (0.56–0.84) compared with Africans (0.10) or Europeans (0.17). homozygous (nonfunctional <i>LILRA3</i>) has been demonstrated to be associated Sjogren's syndrome (SS) multiple sclerosis (MS) Caucasians. However, our...
Objective: To assess physicians’ knowledge and awareness of chronic pain associated with rheumatoid arthritis (RA) in Rheumatology departments throughout Zhejiang province to improve relief RA patients. Methods: A cross-sectional questionnaire survey was conducted onsite online among rheumatologists tertiary secondary hospitals across province, China. The inquired about arthritis-related cognition, assessment, management protocols, medication choice. Results: Among the 150 questionnaires...
To investigate the expression of leukocyte immunoglobulin-like receptor A3 (LILRA3) in CD14+ monocytes patients with rheumatoid arthritis (RA).Fifty three RA admitted Second Affiliated Hospital Zhejiang University School Medicine from February 2017 to August 2017, and 21 healthy subjects were enrolled study. The LILRA3 monocyte subset was determined by flow cytometry, its correlations clinical features, laboratory examination results, antibodies disease activity analyzed.LILRA3 percentage...
Previously we reported functional leukocyte immunoglobulin-like receptor A3 (LILRA3) leads to susceptibility and sub-phenotypes of several autoimmune diseases. LILRA3 levels in blood serum CD14+ monocytes enhanced systemic lupus erythematosus resulted disease severity. However, the mechanism pathogenesis autoimmunity remains elusive. This study aims explore potential impact on differentiation, maturation, function monocyte-derived DCs (MoDCs).The human monocytic cell line (THP-1) was...