Xinrui Li

ORCID: 0000-0002-3712-167X
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About
Contact & Profiles
Research Areas
  • Stress Responses and Cortisol
  • Wildlife Ecology and Conservation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Tryptophan and brain disorders
  • Primate Behavior and Ecology
  • Birth, Development, and Health
  • Sleep and Wakefulness Research
  • Single-cell and spatial transcriptomics
  • Color perception and design
  • Sleep and related disorders
  • Oral Health Pathology and Treatment
  • Neurogenesis and neuroplasticity mechanisms
  • Botulinum Toxin and Related Neurological Disorders
  • Regional Development and Environment
  • Neuroendocrine regulation and behavior
  • Interactive and Immersive Displays
  • Maternal Mental Health During Pregnancy and Postpartum
  • Whipple's Disease and Interleukins
  • Identity, Memory, and Therapy
  • Neurological Disease Mechanisms and Treatments
  • Energy, Environment, Economic Growth
  • Infectious Encephalopathies and Encephalitis
  • Digital Media and Visual Art
  • Immune cells in cancer
  • Multisensory perception and integration

Washington State University
2024-2025

Xuzhou Medical College
2024

Nanjing Medical University
2023-2024

State Key Laboratory of Reproductive Medicine
2024

Hangzhou City University
2024

Sichuan University of Science and Engineering
2023

Hebei Medical University
2022-2023

Harbin Medical University
2022

Fourth Affiliated Hospital of Harbin Medical University
2022

Peking University
2022

The striato-nigral (Str-SN) circuit is composed of medium spiny neuronal projections that are mainly sent from the striatum to midbrain substantial nigra (SN), which essential for regulating motor behaviors. Dysfunction Str-SN circuitry may cause a series disabilities associated with neurodegenerative disorders, such as Huntington's disease (HD). Although etiology HD known abnormally expanded CAG repeats huntingtin gene, treatment remains tremendously challenging. One possible reason lack...

10.1073/pnas.2316176121 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2024-05-21

Abstract Human stem cells and derivatives transplantation are widely used to treat nervous system diseases, while the fate determination of transplanted is not well elucidated. To explore cell changes human brain organoids before after transplantation, into prefrontal cortex (PFC) hippocampus (HIP), respectively. Single‐cell sequencing then performed. According time‐series sample comparison, mainly undergo neural development at 2 months post‐transplantation (MPT) glial 4MPT, A different...

10.1002/advs.202402287 article EN cc-by Advanced Science 2024-05-06

Multipath continues to pose a significant challenge for the Global Navigation Satellite System (GNSS) technique in achieving precise Precise Point Positioning (PPP). Sidereal Filtering (SF) and multipath hemispherical map (MHM) represent common methods mitigating by leveraging satellite temporal spatial repeatability. However, effectiveness of these approaches relies heavily on quality correction model derived from preceding PPP residuals, which often contains product parameter estimation...

10.5194/egusphere-egu25-2304 preprint EN 2025-03-14

Audiovisual integration significantly changes over the lifespan, but age-related functional connectivity in audiovisual temporal asynchrony tasks remains underexplored. In present study, electroencephalograms (EEGs) of 27 young adults (22-25 years) and 25 old (61-76 were recorded during an task with seven conditions [auditory (A), visual (V), AV, A50V, A100V, V50A V100A]. We calculated phase lag index (PLI)-weighted networks modulated by found that PLI connections showed obvious dynamic...

10.3389/fnagi.2018.00316 article EN cc-by Frontiers in Aging Neuroscience 2018-10-09

Abstract Changes in land use and the conversion of natural forests to agricultural fields cattle pastures are threatening survival many species wild animals, including nonhuman primates. Given its almost 1.4 billion people, China faces a difficult challenge balancing economic development, human well‐being, environmental protection, animal conservation. We examined effects poverty, anthropogenic (cropland pasture/grazing), population growth, government investment science public attention...

10.1002/ajp.23302 article EN American Journal of Primatology 2021-07-12

GABAergic network activity plays a crucial role in wide array of physiological processes and is implicated various pathological conditions. While extensive research has been conducted on how modulates both excitatory inhibitory synaptic transmission the CA1 region, mechanisms by which it influences entorhinal cortex-dentate gyrus (EC-DG) circuits are still largely unexplored. Using combination whole-cell patch-clamp recordings, optogenetics, immunohistochemistry, behavioral assays, we...

10.1002/glia.24649 article EN Glia 2024-11-21

Background. Infection with the periodontal pathogen Fusobacterium nucleatum (F. nucleatum) has been associated gastric cancer. The present study is aimed at uncovering putative biological mechanisms underlying effects of F. nucleatum–mediated neutrophil transcriptional deregulation in Materials and Methods. A gene expression dataset pertaining to nucleatum-infected human neutrophils was utilized identify differentially expressed genes (DEGs) using GEO2R tool. Candidate cancer were sourced...

10.1155/2022/9584507 article EN Disease Markers 2022-08-18

Hydrogen sulfide (H2S) is a crucial endogenous gas signaling molecule in the central nervous system, playing significant role anti-inflammation, anti-oxidation, and neuroprotection. Our previous studies have shown that level of H2S closely related to hypothalamic inflammation-induced obesity. However, specific cellular events underlying this modulation remain ambiguously defined. Astrocytes, compared neurons, exhibit preferential activation response high-fat diet-induced inflammation....

10.2139/ssrn.4717132 preprint EN 2024-01-01

This paper applies the quantitative method of policy text to construct an evaluation index system based on PMC model quantitatively evaluate long-term care insurance policies introduced in Chengdu and Chongqing since 2017. The study finds that have dilemmas terms subjects, areas, tool combinations. direction future optimization should strengthen collaboration between departments; focus development weak areas; optimize combination tools.

10.61935/asder.3.1.2024.p38 article EN Advances in Social Development and Education Research 2024-07-16

The past years have seen the subtle changes of relationship between human and products when technology developed consumer requirement increased, during which feelings are much concerned within design process. This paper introduces concept emotional interactive experience based on behavior through life light proposes new interaction method. When using product model, it brings users behaviors from to thinking, not only achieving an physical products, but also seeking leading future interaction.

10.1109/icsem.2010.128 article EN International Conference on System science, Engineering design and Manufacturing informatization 2010-11-01

This paper introduces the Prison Breach, an interactive toy prototype designed for children aged 5-8. Using story of escape and manhunt as background, it endues two robots with roles a thief policeman. By turning discs on which there prints lines to change path, users can control movement robots, they get feedback whether escapes or policeman seizes thief, in this way, user interacts interesting challenging other players well. Taking Breach example, puts forward five elements included good...

10.1109/icsem.2010.120 article EN International Conference on System science, Engineering design and Manufacturing informatization 2010-11-01
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