A5102920937- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Apelin-related biomedical research
- Retinoids in leukemia and cellular processes
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Genetic Syndromes and Imprinting
- Reproductive Physiology in Livestock
- Cancer, Hypoxia, and Metabolism
- Food Safety and Hygiene
- Digestive system and related health
- Listeria monocytogenes in Food Safety
- Cardiovascular Disease and Adiposity
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Obesity, Physical Activity, Diet
- Genetic and phenotypic traits in livestock
- Invertebrate Immune Response Mechanisms
- Tissue Engineering and Regenerative Medicine
Washington State University
2013-2025
Abstract Aging usually involves the progressive development of certain illnesses, including diabetes and obesity. Due to incapacity form new white adipocytes, adipose expansion in aged mice primarily depends on adipocyte hypertrophy, which induces metabolic dysfunction. On other hand, brown tissue burns fatty acids, preventing ectopic lipid accumulation diseases. However, capacity brown/beige adipogenesis declines inevitably during aging process. Previously, we reported that DNA...
The obesity rate is rapidly increasing, which has been attributed to lack of exercise and excessive energy intake. Here, we found a previously unidentified explanation, due maternal exercise. In this study, healthy mice were assigned either sedentary lifestyle or daily, fetal brown adipose tissue (BAT) development offspring metabolic health analyzed. Compared the group, enhanced DNA demethylation Prdm16 promoter BAT prevented when challenged with high-energy diet. Apelin, an exerkine, was...
Formation of beige adipocytes within white adipose tissue enhances energy expenditure, which is a promising strategy to reduce obesity and prevent metabolic symptoms. Vitamin A its bioactive metabolite, retinoic acid (RA), have regulatory roles in lipid metabolism. Here we report that RA induces browning via activating vascular endothelial growth factor (VEGF) signaling. triggered angiogenesis elicited de novo generation platelet-derived receptor α positive (PDGFRα+) precursor cells...
Key points Maternal exercise improves the metabolic health of maternal mice challenged with a high‐fat diet. Exercise intervention obese mothers prevents fetal overgrowth. reverses impaired placental vascularization in mice. activates AMP‐activated protein kinase, which was inhibited as result obesity. Abstract More than one‐third pregnant women USA are and obesity (MO) negatively affects development, predisposes offspring to diseases. The placenta mediates nutrient delivery fetuses its...
During muscle regeneration, excessive formation of adipogenic and fibrogenic tissues, from their respective fibro/adipogenic progenitors (FAPs), impairs functional recovery. Intrinsic mechanisms controlling the proliferation differentiation FAPs remain largely unexplored.
Abstract Maternal obesity (MO) predisposes offspring to and metabolic disorders but little is known about the contribution of brown adipose tissue (BAT). We find that MO impairs fetal BAT development, which persistently suppresses thermogenesis primes female dysfunction. In BAT, enhances expression Dio 3, encodes deiodinase 3 (D3) catabolize triiodothyronine (T3), while a maternally imprinted long noncoding RNA, Dio3 antisense RNA ( Dio3os ), inhibited, leading intracellular T3 deficiency...
ABSTRACT Background Maternal obesity (MO) impairs fetal skeletal muscle development, but the underlying mechanisms remain poorly defined. The regulatory roles of lncRNA H19 and its first exon derived microRNA675 ( miR675 ) in prenatal development to be examined. / Igf2 are same imprinting cluster with expressed from maternal allele while expresses paternally. contains a G‐rich loop, KH‐type splicing protein (KHSRP) mediates biogenesis pre‐ miRNAs containing loops, which depends on...
Although maternal exercise (ME) becomes increasingly uncommon, the effects of ME on offspring muscle metabolic health remain largely undefined. Maternal mice are subject to daily during pregnancy, which enhances mitochondrial biogenesis fetal development; this is correlated with higher content and oxidative fibers in improved endurance capacity. Apelin, an exerkine, elevated due ME, apelin administration mirrors effect muscle. Importantly, both induce DNA demethylation peroxisome...
The objective of this research was to examine the population structure full-blood (100%) Wagyu cattle registered in United States with American Association, aim estimating and comparing levels inbreeding from both pedigree genotypic data. A total 4132 pedigrees were assessed used compute coefficients (FIT FST ) effective size (Ne data for period 1994 2011. In addition analysis, 47 representing eight prominent sire lines genotyped using Illumina BovineSNP50 BeadChip. Genotypic then estimate...
Highlights•Maternal vitamin A supplementation increases blood vessel density and expands adipose progenitor population in progeny.•Maternal enhances brown-like phenotype tissues.•Maternal protects offspring from diet induced obesity.Vitamin its metabolite, retinoic acid, play key roles adipogenesis energy expenditure of tissues. In mice humans, intake is inversely correlated with adiposity. This study has uncovered a role for maternal retinoids fetal development. Maternal or RA...
Maternal stress during pregnancy exposes fetuses to hyperglucocorticoids, which increases the risk of metabolic dysfunctions in offspring. Despite being a key tissue for maintaining health, impacts maternal excessive glucocorticoids (GC) on fetal brown adipose (BAT) development and its long-term thermogenesis energy expenditure remain unexamined. For testing, pregnant mice were administered dexamethasone (DEX), synthetic GC, last trimester gestation, when BAT is most active. DEX offspring...
Abstract Due to the exclusive maternal transmission, oocyte mitochondrial dysfunction reduces fertility rates, affects embryonic development, and programs offspring metabolic diseases. However, DNA (mtDNA) are vulnerable mutations during maturation, leading nucleotide variations (mtSNVs) within a single oocyte, referring mtDNA heteroplasmy. Obesity (OB) accounts for more than 40% of women at reproductive age in USA, but little is known about impacts OB on mtSNVs mature oocytes. It found that...
Vitamin A and its metabolite, retinoic acid (RA), are important regulators of cell differentiation organ morphogenesis. Its impact on beef cattle muscle growth remains undefined.Angus steer calves were administrated with 0 (control) or 150,000 IU vitamin (retinyl palmitate in glycerol, i.m.) per calf at birth 1 month age. At 2 months age, a biopsy the Biceps femoris was obtained to analyze immediate effects injection myogenic capacity cells. The resulting steers harvested 14 age.Vitamin...
Abstract Background Following muscle injury, fibro‐adipogenic progenitors (FAPs) are rapidly activated and undergo apoptosis at the resolution stage, which is required for proper regeneration. When excessive FAPs remain, it contributes to fibrotic fatty infiltration, impairing recovery. Mechanisms controlling FAP remain poorly defined. We hypothesized that AMP‐activated protein kinase (AMPK) in mediates their during Methods To test, AMPKα1 fl/fl PDGFRα Cre mice were used knock out FAPs....
Obesity during pregnancy leads to adverse health outcomes in offspring. However, the initial effects of maternal obesity (MO) on embryonic organogenesis have yet be thoroughly examined. Using unbiased single-cell transcriptomic analyses (scRNA-seq), MO myogenic process is investigated day 9.5 (E9.5) mouse embryos. The results suggest that induces systematic hypoxia, which correlated with enhanced BMP signaling and impairs skeletal muscle differentiation within dermomyotome (DM)....
Maternal exercise (ME) protects against adverse effects of maternal obesity (MO) on fetal development. As a cytokine stimulated by exercise, apelin (APN) is elevated due to ME, but its roles in mediating the ME placental development remain be defined. Two studies were conducted. In first study, 18 female mice assigned control (CON), obesogenic diet (OB), or OB with (OB/Ex) groups (n = 6); second same number three groups; CON PBS injection (CD/PBS), OB/PBS, (OB/APN). daily treadmill during...