A5103069655- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Exercise and Physiological Responses
- Genetics, Aging, and Longevity in Model Organisms
- Fatty Acid Research and Health
- Chemical Analysis and Environmental Impact
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Water Treatment and Disinfection
- Diet and metabolism studies
- Oral microbiology and periodontitis research
- ATP Synthase and ATPases Research
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and biosynthesis
- Aquaculture Nutrition and Growth
- Probiotics and Fermented Foods
- Cardiovascular Disease and Adiposity
- Spinal Hematomas and Complications
- DNA Repair Mechanisms
- Mosquito-borne diseases and control
- Gestational Diabetes Research and Management
- Vitamin C and Antioxidants Research
University of Massachusetts Chan Medical School
2018-2024
Chongqing Medical University
2024
Mianyang Third People's Hospital
2023-2024
Fujian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Sichuan Agricultural University
2022-2023
Sichuan University
2020-2022
State Key Laboratory of Oral Diseases
2020-2022
West China Hospital of Sichuan University
2022
Washington State University
2013-2021
Maternal high-fat diet impairs brown adipocyte function and correlates with obesity in offspring. resveratrol administration recovers metabolic activity of offspring adipose tissue. promotes beige development white intervention protects against diet-induced obesity.Promoting beige/brite adipogenesis thermogenic is considered as a promising therapeutic approach to reduce syndrome. We previously found that dietary (RES) induces formation adult mice. Here, we evaluated further the effect...
Maternal obesity (MO) predisposes offspring to and type 2 diabetes despite poorly defined mechanisms. Zfp423 is the key transcription factor committing cells adipogenic lineage, with exceptionally dense CpG sites in its promoter. We hypothesized that MO enhances differentiation during fetal development through inducing epigenetic changes promoter elevating expression. Female mice were subjected a control (Con) or obesogenic (OB) diet for months, mated, maintained on their diets pregnancy....
Enhancing the formation and function of brown adipose tissue (BAT) increases thermogenesis hence reduces obesity. Thus, we investigate effects resveratrol (Resv) on adipocyte in mouse interscapular BAT (iBAT).CD1 mice stromal vascular cells (SVCs) isolated from iBAT were treated with Resv. Expression adipogenic thermogenic markers, involvement AMP-activated protein kinase (AMPK)α1 assessed. In vivo, Resv-enhanced expression PR domain-containing 16 (PRDM16) genes, uncoupling 1 (UCP1)...
Abstract As organisms develop, individual cells generate mitochondria to fulfill physiological requirements. However, it remains unknown how mitochondrial network expansion is scaled cell growth. The unfolded protein response (UPR mt ) a signaling pathway mediated by the transcription factor ATFS-1 which harbors targeting sequence (MTS). Here, using model organism Caenorhabditis elegans we demonstrate that mediates an adaptable program active throughout normal development. Mitochondrial...
Abstract Aging usually involves the progressive development of certain illnesses, including diabetes and obesity. Due to incapacity form new white adipocytes, adipose expansion in aged mice primarily depends on adipocyte hypertrophy, which induces metabolic dysfunction. On other hand, brown tissue burns fatty acids, preventing ectopic lipid accumulation diseases. However, capacity brown/beige adipogenesis declines inevitably during aging process. Previously, we reported that DNA...
Background Previous studies have shown that the Unilateral Biportal Endoscopy is an effective and safety surgery for sufficient decompression of degenerative lumbar spinal stenosis. However, data are lacking in terms its benefits when compared with conventional open discectomy (OLD), especially patients severe stenosis (DLSS). Aim To compare clini cal outcomes two types decompressive surgery: unilateral biportal endoscopy-unilateral laminectomy bilateral (UBE-ULBD) (OLD) Methods We...
Maternal obesity and high-fat diet (HFD) predisposes offspring to metabolic diseases. Due uncoupling, brown adipose tissue (BAT) dissipates energy via heat generation, mitigating diabetes. The lactation stage is a manageable period for improving the health of obese mothers, but impact maternal HFD during on BAT function unknown. To determine, female mice were fed either control or lactation. At weaning, gained more body weight had greater fat mass compared control, these differences...
Maternal obesity reduces adipogenic progenitor density in offspring adipose tissue. The ability of tissue expansion the obese mothers is limited and associated with metabolic dysfunction when challenged a high-fat diet. induces DNA demethylation promoter zinc finger protein 423, which renders cells high capacity. demonstrates long-term effects on capacity tissue, demonstrating developmental programming effect.Maternal (MO) programs disorders, although underlying mechanisms remain poorly...
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host responses following recognition of specific endogenous or exogenous ligands. Although NHRs have expanded dramatically in C. elegans compared to other metazoans, the biological function only a few these genes has been characterized detail. Here, we demonstrate an NHR can activate anti-pathogen transcriptional program. Using genetic epistasis experiments, transcriptome profiling analyses and...
Abstract Analysis of off-target editing is an important aspect the development safe nuclease-based genome therapeutics. in vivo assessment nuclease activity has primarily been indirect (based on discovery vitro, cells or via computational prediction) through ChIP-based detection double-strand break (DSB) DNA repair factors, which can be cumbersome. Herein we describe GUIDE-tag, enables one-step, analysis mouse liver and lung. The GUIDE-tag system utilizes tethering between Cas9 donor to...
Oxidative stress is known to be associated with the development of diabetes. Cinnamaldehyde (CA) a spice compound in cinnamon that enhances antioxidant defense against reactive oxygen species (ROS) by activating nuclear factor erythroid-related 2 (Nrf2), which has been shown have cardioprotection effect. However, relationship between CA and Nrf2 diabetic vascular complications remains unclear.Leptin receptor-deficient (db/db) mice were fed normal chow or diet containing 0.02% for 12 weeks....
Abstract Maternal obesity (MO) predisposes offspring to and metabolic disorders but little is known about the contribution of brown adipose tissue (BAT). We find that MO impairs fetal BAT development, which persistently suppresses thermogenesis primes female dysfunction. In BAT, enhances expression Dio 3, encodes deiodinase 3 (D3) catabolize triiodothyronine (T3), while a maternally imprinted long noncoding RNA, Dio3 antisense RNA ( Dio3os ), inhibited, leading intracellular T3 deficiency...
Although skeletal progenitors provide a reservoir for bone-forming osteoblasts, the major energy source their osteogenesis remains unclear. Here, we demonstrate requirement mitochondrial oxidative phosphorylation in osteogenic commitment and differentiation of progenitors. Deletion Evolutionarily Conserved Signaling Intermediate Toll pathways (ECSIT) hinders bone formation regeneration, resulting deformity, defects marrow niche spontaneous fractures followed by persistent nonunion. Upon...
Exposure to drinking water disinfection byproducts (DBPs) is potentially associated with adverse developmental effects. Iodoacetic acid (IAA), an unregulated DBP, has been shown be cytotoxic, mutagenic, genotoxic, and tumorigenic. However, its endocrine-disrupting effects remain unknown. This study evaluated the IAA-induced disruption of thyroid endocrine system using in vitro vivo assays. Rat pituitary tumor GH3 cells were treated IAA presence absence triiodothyronine (T3). exposure...
Maternal stress during pregnancy exposes fetuses to hyperglucocorticoids, which increases the risk of metabolic dysfunctions in offspring. Despite being a key tissue for maintaining health, impacts maternal excessive glucocorticoids (GC) on fetal brown adipose (BAT) development and its long-term thermogenesis energy expenditure remain unexamined. For testing, pregnant mice were administered dexamethasone (DEX), synthetic GC, last trimester gestation, when BAT is most active. DEX offspring...
Iodoacetic acid (IAA) is the most genotoxic iodinated disinfection byproduct known in drinking water. Previous studies have shown that IAA may be an endocrine disruptor. However, whether has reproductive and developmental toxicity remains unclear. In this study, of was evaluated using a battery vitro vivo reproductive/developmental screening tests. The results E-Screen, uterotrophic, H295R steroidogenesis assays were negative. Hershberger bioassay revealed could induce significant increases...
Abstract Due to the exclusive maternal transmission, oocyte mitochondrial dysfunction reduces fertility rates, affects embryonic development, and programs offspring metabolic diseases. However, DNA (mtDNA) are vulnerable mutations during maturation, leading nucleotide variations (mtSNVs) within a single oocyte, referring mtDNA heteroplasmy. Obesity (OB) accounts for more than 40% of women at reproductive age in USA, but little is known about impacts OB on mtSNVs mature oocytes. It found that...