A5103217256- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Adrenal and Paraganglionic Tumors
- Atherosclerosis and Cardiovascular Diseases
- Adrenal Hormones and Disorders
- Cardiovascular Health and Risk Factors
- Cardiovascular Health and Disease Prevention
- Advanced Glycation End Products research
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Channels and Receptors
- Phytochemicals and Antioxidant Activities
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Natural Antidiabetic Agents Studies
- Mitochondrial Function and Pathology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Caveolin-1 and cellular processes
- Postharvest Quality and Shelf Life Management
First Affiliated Hospital of Chengdu Medical College
2016-2025
Chengdu Medical College
2020-2025
Oxidative stress is known to be associated with the development of diabetes. Cinnamaldehyde (CA) a spice compound in cinnamon that enhances antioxidant defense against reactive oxygen species (ROS) by activating nuclear factor erythroid-related 2 (Nrf2), which has been shown have cardioprotection effect. However, relationship between CA and Nrf2 diabetic vascular complications remains unclear.Leptin receptor-deficient (db/db) mice were fed normal chow or diet containing 0.02% for 12 weeks....
Emerging research indicates a potential pathogenic overlap between primary aldosteronism (PA) and aortic aneurysm (AA)/aortic dissection (AD). Despite case reports suggest link PA AA/AD, the causality of this relationship remains unclear. This study is first to elucidate causal association genetically predicted risk AA AD through Mendelian randomization (MR) analysis. Genome-wide significant single nucleotide polymorphisms associated with were identified from publicly available genome-wide...
Objectives Chlorogenic acid (CGA) is an antioxidant dietary factor. We investigated the effects of CGA on endothelial cell dysfunction in diabetic mice and mechanistic role nuclear factor erythroid-related 2 (Nrf2) effect CGA. Methods Diabetic (db/db) were fed normal chow or containing 0.02% for 12 weeks. Human umbilical vein cells (HUVECs) mouse aortas treated with high glucose. Results treatment induced upregulation Nrf2 HUVECs a dose-dependent manner. pretreatment prevented reactive...
Superselective adrenal arterial embolization (SAAE) is an alternative treatment for patients with primary aldosteronism (PA). This single-center prospective cohort study aimed to compare the efficacy of SAAE mineralocorticoid receptor antagonists (MRA) in treating PA who refused unilateral adrenalectomy.Of 140 were enrolled and completed 12-month follow-up, 74 underwent 66 received MRA treatment. The clinical biochemical outcome was compared at 1, 6, 12 months after procedure.Baseline...
Abstract: Oxidative stress plays a critical role in diabetic cardiomyopathy. Transient receptor potential ankyrin subtype 1 (TRPA1) has antioxidative property. In this study, we tested whether activation of TRPA1 with cinnamaldehyde protects against high-glucose–induced cardiomyocyte injury. Cinnamaldehyde remarkably decreased mitochondrial superoxide overproduction, upregulation nitrotyrosine, P22 phox , and P47 apoptosis cultured H9C2 cardiomyocytes ( P < 0.01), which were abolished by...
There is a lack of studies that evaluate the association between normal weight central obesity and subsequent outcomes in patients with premature acute coronary syndrome (ACS). We evaluated 338 consecutive male (aged ≤ 55 years) ACS. The primary were all-cause mortality major adverse cardiac cerebrovascular events (MACCE). compared hazard ratios (HRs) without using multivariable Cox proportional models. All-cause (16.8%) was much higher than those (7.1%) (P = .008). incidence MACCE 40.7...
Abstract Background Adrenal vein sampling (AVS) is the preferred method for subtyping patients with primary aldosteronism, while procedure technically challenging. This study evaluated feasibility and effectiveness of a single-catheter approach AVS. Methods A retrospective analysis 106 consecutive who underwent AVS was performed to determine procedural success complication rates. Bilateral procedures were using single 5-Fr Tiger catheter repeated manual reshaping. Results We successfully...
The Tiaopi Huxin recipe (TPHXR) is widely used in traditional Chinese medicine for the clinical treatment of coronary heart disease. However, mechanism TPHXR atherosclerosis (AS) has not been fully elucidated. In this study, we have aimed to explore potential antiatherosclerotic effect and its underlying mechanisms. Male ApoE knockout (ApoE-/- ) mice were fed a high-fat diet 12 weeks randomly divided into four groups: control group, low-dose, medium-dose, high-dose groups. nitric oxide (NO)...
Background: Arterial pressure volume index (API) and arterial velocity pulse (AVI) contribute to the development of vascular damage cardiovascular disease. However, relationship between common API/AVI trajectories outcomes in hypertensive patients with heart failure preserved ejection fraction (HFpEF) is unknown.Methods: A total 488 consecutive HFpEF who repeatedly underwent measurements were prospectively examined. We then applied into actual clinical practice. Latent mixture modeling was...
Hypertension-mediated organ damage (HMOD) is an emerging problem among young adults. The potential role of chronic immune-mediated inflammation in the pathogenesis HMOD increasingly being recognized. High-mobility group box 2 (HMGB2) known for its modulation innate immunity and exerts signaling functions that affect various inflammatory diseases. However, association between HMGB2 adults remains unclear.The aim this study was to explore subclinical adults.This a cross-sectional study.Body...
Waist-to-hip ratio (WHR) is a strong predictor of mortality in patients with heart failure (HF). However, common WHR trajectories are not well established HF mid-range ejection fraction (HFmrEF) persons, and their relationship to clinical outcomes remains uncertain.We prospectively enrolled 1,396 participants HFmrEF (left ventricular 40-49%) from April 2013 through 2017. The waist hip circumferences the subjects were measured at regular intervals, was calculated as circumference divided by...
Background/Aims: Bleeding complications after percutaneous coronary intervention (PCI) are strongly associated with adverse patient outcomes. However, there no specific guidelines for the predictors and management of antiplatelet-related bleeding in Chinese elderly patients acute syndrome (ACS). Methods: A retrospective analysis 237 consecutive (aged ≥ 75 years) ACS who had undergone successful PCI from January 2010 to December 2016 was performed identify complications. Multivariate logistic...
Adrenal vein sampling (AVS) is an established procedure for assessing subtype patients with primary aldosteronism (PA). However, it technically challenging, high failure rates, which limits its application in clinical practice. Our study aimed to evaluate the safety and efficacy of a single-catheter modified approach AVS.The clinical, angiographic, procedural data 182 consecutive who underwent AVS procedures between May 2020 2023 were collected analyzed. The was performed as single 5 F Tiger...
Background: Antithrombotic therapy is a cornerstone of acute myocardial infarction (AMI) treatment and thought to be associated with an increased risk chronic subdural hematoma (CSDH). However, no well-established model exists predict subsequent antithrombotic outcomes after CSDH in patients recent AMI. We aimed identify prognostic the 6-month outcome therapy. Methods: This multicenter retrospective analysis involved 553 AMI antithrombotic-related CSDH. Several candidate clinical variables...
Background: Primary aldosteronism (PA) is a prevalent cause of endocrine hypertension characterized by an excess aldosterone that can induce proinflammatory, prooxidant, and profibrotic effects on the heart. Emerging evidence indicates heightened incidence atrial fibrillation (AF) in patients with PA, suggesting significant association between two conditions. However, underlying mechanisms remain unclear. The purpose this study was to investigate molecular networks associated development...
Abstract Background Catheter-based renal denervation (RDN) has been introduced to treat resistant hypertension. Although the technology of RDN largely improved, tortuous arteries remains challenging. Case presentation This is a case report 49-year-old man with drug The patient was selected for after ruling out possible causes secondary Computed tomography angiography showed highly left artery. An Iberis multielectrode ablation catheter failed reach target vessel regular guiding catheter. A...