A5101503812- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Elasticity and Material Modeling
- Functional Brain Connectivity Studies
- Adrenal Hormones and Disorders
- Blood Pressure and Hypertension Studies
- Blood properties and coagulation
- Advanced Neuroimaging Techniques and Applications
- Image Processing and 3D Reconstruction
- Machine Learning in Materials Science
- Automotive and Human Injury Biomechanics
- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Ion Channels and Receptors
- Software-Defined Networks and 5G
- IoT and Edge/Fog Computing
- Phytochemicals and Antioxidant Activities
- Postharvest Quality and Shelf Life Management
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Fetal and Pediatric Neurological Disorders
First Affiliated Hospital of Chengdu Medical College
2016-2025
University of Georgia
2023-2025
Chengdu Medical College
2021-2025
NARI Group (China)
2022
Higher Education Press (China)
2022
Sichuan University
2022
Shanghai Jiao Tong University
2021
Xi'an Jiaotong University
2009
The surface morphology of the developing mammalian brain is crucial for understanding function and dysfunction.
Emerging research indicates a potential pathogenic overlap between primary aldosteronism (PA) and aortic aneurysm (AA)/aortic dissection (AD). Despite case reports suggest link PA AA/AD, the causality of this relationship remains unclear. This study is first to elucidate causal association genetically predicted risk AA AD through Mendelian randomization (MR) analysis. Genome-wide significant single nucleotide polymorphisms associated with were identified from publicly available genome-wide...
Objectives Chlorogenic acid (CGA) is an antioxidant dietary factor. We investigated the effects of CGA on endothelial cell dysfunction in diabetic mice and mechanistic role nuclear factor erythroid-related 2 (Nrf2) effect CGA. Methods Diabetic (db/db) were fed normal chow or containing 0.02% for 12 weeks. Human umbilical vein cells (HUVECs) mouse aortas treated with high glucose. Results treatment induced upregulation Nrf2 HUVECs a dose-dependent manner. pretreatment prevented reactive...
Abstract The authors aim to assess the correlation between hypertension and triglyceride‐glucose (TyG) index its associated indices, compare their abilities identify hypertension. Four thousand eight hundred sixty‐six non‐hypertensive participants were enrolled from China National Health Survey in 2009. data on new‐onset gathered both 2011 2015. TyG indices derived fasting triglyceride, blood glucose levels, anthropometric parameters. Multivariate logistic regression analyses receiver...
Superselective adrenal arterial embolization (SAAE) is an alternative treatment for patients with primary aldosteronism (PA). This single-center prospective cohort study aimed to compare the efficacy of SAAE mineralocorticoid receptor antagonists (MRA) in treating PA who refused unilateral adrenalectomy.Of 140 were enrolled and completed 12-month follow-up, 74 underwent 66 received MRA treatment. The clinical biochemical outcome was compared at 1, 6, 12 months after procedure.Baseline...
Capsaicin, a transient receptor potential vanilloid 1 channel agonist, possesses antioxidative properties through activating nuclear factor-erythroid 2-related factor 2 (Nrf2). As oxidative stress is major contributor to the development of contrast-associated acute kidney injury (CA-AKI), we investigated protective effect capsaicin against CA-AKI via Nrf2. C57BL/6J mice were treated with dehydration and iodixanol establish model CA-AKI. For pretreatment, (0.3 mg/kg) was given intraperitoneal...
Abstract: Oxidative stress plays a critical role in diabetic cardiomyopathy. Transient receptor potential ankyrin subtype 1 (TRPA1) has antioxidative property. In this study, we tested whether activation of TRPA1 with cinnamaldehyde protects against high-glucose–induced cardiomyocyte injury. Cinnamaldehyde remarkably decreased mitochondrial superoxide overproduction, upregulation nitrotyrosine, P22 phox , and P47 apoptosis cultured H9C2 cardiomyocytes ( P < 0.01), which were abolished by...
Primary aldosteronism is a common cause of resistant hypertension. Patients with primary due to aldosterone-producing adenoma are generally treated unilateral adrenalectomy or medical therapy. Superselective adrenal arterial embolization an alternative treatment for patients aldosteronism.We present 39-year-old male patient 5-year history and secondary The refused while accepted pharmacotherapy. Despite taking adequate dose spironolactone, the experienced repeatedly muscle weakness...
The human brain development experiences a complex evolving cortical folding from smooth surface to convoluted ensemble of folds. Computational modeling has played an essential role in better understanding the process folding, but still leaves many questions be answered. A major challenge faced by computational models is how create massive developmental simulations with affordable sources complement neuroimaging data and provide reliable predictions for folding. In this study, we leveraged...
We introduce a data-driven framework to automatically identify interpretable and physically meaningful hyperelastic constitutive models from sparse data. Leveraging symbolic regression, an algorithm based on genetic programming, our approach generates elegant that achieve accurate data fitting through parsimonious mathematic formulae, while strictly adhering hyperelasticity constraints such as polyconvexity. Our investigation spans three distinct models—invariant-based, principal...
This study aimed at developing and validating a risk score to predict in-stent restenosis (ISR) in patients with premature acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) drug-eluting stent (DES).
The surface morphology of the developing mammalian brain is crucial for understanding function and dysfunction. Computational modeling offers valuable insights into underlying mechanisms early folding. Recent findings indicate significant regional variations in tissue growth, while role these cortical development remains unclear. In this study, we unprecedently explored how growth affects folding patterns using computational simulation. We first developed models typical regions machine...
There is a lack of studies that evaluate the association between normal weight central obesity and subsequent outcomes in patients with premature acute coronary syndrome (ACS). We evaluated 338 consecutive male (aged ≤ 55 years) ACS. The primary were all-cause mortality major adverse cardiac cerebrovascular events (MACCE). compared hazard ratios (HRs) without using multivariable Cox proportional models. All-cause (16.8%) was much higher than those (7.1%) (P = .008). incidence MACCE 40.7...
Abstract Background Adrenal vein sampling (AVS) is the preferred method for subtyping patients with primary aldosteronism, while procedure technically challenging. This study evaluated feasibility and effectiveness of a single-catheter approach AVS. Methods A retrospective analysis 106 consecutive who underwent AVS was performed to determine procedural success complication rates. Bilateral procedures were using single 5-Fr Tiger catheter repeated manual reshaping. Results We successfully...
Traditional computational methods, such as the finite element analysis, have provided valuable insights into uncovering underlying mechanisms of brain physical behaviors. However, precise predictions physics require effective constitutive models to represent intricate mechanical properties tissue. In this study, we aimed identify most favorable material model for human To achieve this, applied artificial neural network and multiple regression methods a generalization widely accepted classic...