A5028495994- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury Research
- Traffic and Road Safety
- Traumatic Brain Injury and Neurovascular Disturbances
- Elasticity and Material Modeling
- Injury Epidemiology and Prevention
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Image Processing and 3D Reconstruction
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Advanced Combustion Engine Technologies
- Machine Learning in Materials Science
- Cardiovascular Health and Disease Prevention
- Biodiesel Production and Applications
- Vehicle emissions and performance
- Geochemistry and Geochronology of Asian Mineral Deposits
- Geological and Geochemical Analysis
- Older Adults Driving Studies
- Geochemistry and Geologic Mapping
- Transportation Safety and Impact Analysis
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Neurological Disease Mechanisms and Treatments
University of Virginia
2008-2025
University of Georgia
2024-2025
Zhejiang Chinese Medical University
2024
University of Pennsylvania
2022-2024
University of Georgia
2024
Beijing University of Chinese Medicine
2024
Xuzhou Medical College
2016-2021
Lianyungang Oriental Hospital
2016-2021
The First People’s Hospital of Lianyungang
2018
Beijing Institute of Technology
2014
Abstract With the growing rate of traumatic brain injury (TBI), there is an increasing interest in validated tools to predict and prevent injuries. Finite element models (FEM) are valuable estimate tissue responses, probability TBI, guide development safety equipment. In this study, we developed anisotropic pig multi-scale FEM by explicitly embedding axonal tract structures utilized model simulate experimental TBI piglets undergoing dynamic head rotations. Binary logistic regression,...
Traumatic brain injury (TBI) is a significant public health burden, and the development of advanced countermeasures to mitigate prevent these injuries during automotive, sports, military impact events requires an understanding intracranial mechanisms related TBI. In this study, efficacy tissue-level metrics for predicting TBI was evaluated using finite element reconstructions from comprehensive, multi-species database. The database consisted human volunteer tests, laboratory-reconstructed...
Obesity is characterized by a chronic low-grade inflammatory condition. Two emerging biomarkers, the systemic immune-inflammation index (SII) and inflammation response (SIRI), have gained attention. However, relationships between obesity SII/SRI remain unclear.
Traumatic brain injuries (TBI) are a substantial societal burden. The development of better technologies and systems to prevent and/or mitigate the severity injury requires an improved understanding mechanisms injury, more specifically, how head impact exposure relates deformation. Biomechanical investigations have used computational models identify these relations, but experimental deformation data needed validate support their conclusions. objective this study was generate dataset...
Scaling methods are used to relate animal exposure data humans by determining equivalent biomechanical impact conditions that result in similar tissue-level mechanics for different species. However, existing scaling traumatic brain injury (TBI) do not account the anatomical and morphological complexity of brains species have been validated based on accurate anatomy realistic material properties. In this study, relationship between TBI condition tissue deformation was investigated using...
Traumatic brain injury (TBI) contributes to a significant portion of the injuries resulting from motor vehicle crashes, falls, and sports collisions. The development advanced countermeasures mitigate these requires complete understanding tolerance human injury. In this study, we developed new method establish levels using an integrated database reconstructed football impacts, subinjurious volunteer data, nonhuman primate data. were analyzed tissue-level metrics determined harmonized...
Objectives The objective of this study was to develop abbreviated injury scale (AIS) 1, AIS2, AIS3 and AIS4+ risk functions (IRFs) for traumatic brain injuries (TBIs) as estimated by the rotational kinematics head, in accordance with AIS1998. effectiveness IRFs investigated comparisons real-world accident data frontal crash configurations. In addition, links developed AIS1998 other AIS versions were discussed.
Concussion is a significant public health problem affecting 1.6-2.4 million Americans annually. An alternative to reducing the burden of concussion reduce its incidence with improved protective equipment and injury mitigation systems. Finite element (FE) models brain response blunt trauma are often used estimate potential can lead helmet designs. However, these have yet incorporate how patterns connectivity disruption after impact affects relay information in injured brain. Furthermore, FE...
Central to the investigation of biomechanics traumatic brain injury (TBI) and assessment risk from head impact are finite element (FE) models human brain. However, many existing FE have been developed with simplified representations parenchyma, which may limit their applicability as an prediction tool. Recent advances in neuroimaging techniques provide new necessary experimental data that can improve biofidelity models. In this study, CAB-20MSym template model was developed, calibrated,...
Objective: The goal of this study was to evaluate the biofidelity Total Human Model for Safety (THUMS; Ver. 4.01) pedestrian finite element models (PFEM) in a whole-body impact condition using well-characterized generic buck model.Methods: THUMS PFEM evaluated with respect data from 3 full-scale postmortem human subject (PMHS) tests, which laterally struck subjects at 40 km/h. model scaled match anthropometry target and then positioned pre-impact postures based on 3-dimensional motion...
The introduction of highly automated vehicles will influence occupant seating behavior and seat design, including broader adoption reclined postures. goal this study was to perform a preliminary assessment the usability two FE models (NHTSA THOR FE, GHBMC Simplified Occupant) examine restraint interactions, kinematics, protection challenges for occupants in frontal collisions. During crash simulations, simplified model tended exhibit greater propensity submarining forward flexion lumbar...
Abstract Introduction To improve the accuracy of ultrasound techniques for assessment carotid stenosis, we designed a novel artery stenosis scale (CASUS), and evaluated its accuracy, reliability, value in predicting occurrence cardiovascular cerebrovascular diseases prospective study. Methods A total 750 patients with first-time ischemic stroke hospitalized within 24 h were enrolled Using color Doppler (CDUS), degree blood flow (BF) bilateral internal arteries (ICA) V1-V3 segment vertebral...
Overweight/obesity combined with depression among children and adolescents (ODCA) is a global concern. The bidirectional relationship between overweight/obesity often leads to their comorbidity. Childhood adolescence represent critical periods for physical psychological development, during which the comorbidity of may increase risk adverse health outcomes.
The brain is a complex network consisting of neuron cell bodies in the gray matter and their axonal projections, forming white tracts. These neurons are supported by an equally vascular as well glial cells. Traumatic injury (TBI) can lead to disruption structural functional networks due both neuronal projections supporting To explore how impact alter function networks, we integrated finite element (FE) mechanics model with linked models dynamics (Kuramoto oscillator) perfusion...
The optimal range of blood pressure levels in the early phase ischemic stroke with hypertension is still controversial. Based on our registry database, we explored relationship between and cerebral perfusion neurofunctional recovery at 3 months after stroke. Total 732 patients were finally analyzed. Patients divided into quintiles according to systolic (SBP) diastolic (DBP) perform multivariable logistic regression analyze their relation recovery, respectively. displayed a reverse "U" shape...
The incidence of corpus callosum infarction is low, and sudden cognitive dysfunction caused by very rare. We report two cases acute with impairment, the related basis, clinical manifestations, diagnosis, differential treatment, prognosis this disease are reviewed.The patients had severe memory impairment spatial orientation disorder. Their function scores were significantly lower, their MRI demonstrated clear infarction. Through symptoms improved significantly.This paper reports its relevant...
With an increasing focus on long-term consequences of concussive brain injuries, there is a new emphasis developing tools that can accurately predict the mechanical response to impact loading. Although finite element models (FEM) estimate under dynamic loading, these are not capable delivering rapid (∼seconds) estimates brain's response. In this study, we develop multibody spring-mass-damper model regional motion rotational accelerations delivered either about one anatomic axis or across...