A5041370805- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Elasticity and Material Modeling
- Injury Epidemiology and Prevention
- Advanced Neuroimaging Techniques and Applications
- Traumatic Ocular and Foreign Body Injuries
- Bone fractures and treatments
- Medical Imaging and Analysis
- Traffic and Road Safety
- Inertial Sensor and Navigation
- Sports injuries and prevention
- Functional Brain Connectivity Studies
- Sports Analytics and Performance
- Medical and Biological Sciences
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Effects of Vibration on Health
- Sports Dynamics and Biomechanics
- Spine and Intervertebral Disc Pathology
- Target Tracking and Data Fusion in Sensor Networks
- Musculoskeletal pain and rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Spinal Cord Injury Research
University of Virginia
2017-2023
University of Pennsylvania
2017
CURE International UK
2017
Medical College of Wisconsin
2017
Philadelphia University
2017
Traumatic brain injuries (TBI) are one of the least understood to body. Finite element (FE) models have been crucial for understanding concussion and developing injury mitigation systems; however, experimental deformation data currently used validate these limited. The objective this study was develop a methodology investigation in situ three-dimensional during pure rotational loading head, using sonomicrometry. Sonomicrometry uses ultrasonic pulses measure dynamic distances between...
Traumatic brain injury (TBI) is a significant public health burden, and the development of advanced countermeasures to mitigate prevent these injuries during automotive, sports, military impact events requires an understanding intracranial mechanisms related TBI. In this study, efficacy tissue-level metrics for predicting TBI was evaluated using finite element reconstructions from comprehensive, multi-species database. The database consisted human volunteer tests, laboratory-reconstructed...
Traumatic brain injuries (TBI) are a substantial societal burden. The development of better technologies and systems to prevent and/or mitigate the severity injury requires an improved understanding mechanisms injury, more specifically, how head impact exposure relates deformation. Biomechanical investigations have used computational models identify these relations, but experimental deformation data needed validate support their conclusions. objective this study was generate dataset...
Scaling methods are used to relate animal exposure data humans by determining equivalent biomechanical impact conditions that result in similar tissue-level mechanics for different species. However, existing scaling traumatic brain injury (TBI) do not account the anatomical and morphological complexity of brains species have been validated based on accurate anatomy realistic material properties. In this study, relationship between TBI condition tissue deformation was investigated using...
Traumatic brain injury (TBI) contributes to a significant portion of the injuries resulting from motor vehicle crashes, falls, and sports collisions. The development advanced countermeasures mitigate these requires complete understanding tolerance human injury. In this study, we developed new method establish levels using an integrated database reconstructed football impacts, subinjurious volunteer data, nonhuman primate data. were analyzed tissue-level metrics determined harmonized...
Concussion is a significant public health problem affecting 1.6-2.4 million Americans annually. An alternative to reducing the burden of concussion reduce its incidence with improved protective equipment and injury mitigation systems. Finite element (FE) models brain response blunt trauma are often used estimate potential can lead helmet designs. However, these have yet incorporate how patterns connectivity disruption after impact affects relay information in injured brain. Furthermore, FE...
Central to the investigation of biomechanics traumatic brain injury (TBI) and assessment risk from head impact are finite element (FE) models human brain. However, many existing FE have been developed with simplified representations parenchyma, which may limit their applicability as an prediction tool. Recent advances in neuroimaging techniques provide new necessary experimental data that can improve biofidelity models. In this study, CAB-20MSym template model was developed, calibrated,...
Abstract In the last decade, computational models of brain have become gold standard tool for investigating traumatic injury (TBI) mechanisms and developing novel protective equipment other safety countermeasures. However, most studies utilizing finite element (FE) been conducted using developed to represent average neuroanatomy a target demographic, such as 50th percentile male. Although this is an efficient strategy, it neglects normal anatomical variations present within population their...
As human body finite element models become more integrated with the design of safety countermeasures and regulations, novel need to be developed that reflect variation in population's anthropometry. However, these new may missing information which will translated from existing models. During development a 5th percentile female occupant model (F05), cortical thickness coxal bone was unavailable due resolution limits computed tomography (CT) scans. In this study, method for transferring source...
Female occupants sustain high frequency of injury to the foot and ankle in motor vehicle crashes (MVCs). To investigate mechanisms, this study evaluated a finite element model small female occupant (F05). The was validated four loading conditions relevant MVCs (axial rotation,dynamic inversion eversion, dorsiflexion axial impact) scaling approaches were applied available post-mortem human surrogate data provide appropriate boundary experimental biofidelity targets. Compared an average male...
Human induced pluripotent stem cell-derived neural cells (hiPS-NSCs) represent an exciting therapeutic strategy for traumatic spinal cord injury (SCI) as they can replace lost circuits, remyelinate denuded axons and provide local trophic support.Unfortunately, most patients are in the chronic phase of their injuries where dense chondroitin sulfate proteoglycan (CSPG) scarring significantly impairs neurite outgrowth regenerative cell migration.Several scarmodifying enzymes have been shown to...