A5100689803- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Reproductive System and Pregnancy
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Congenital Diaphragmatic Hernia Studies
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- Neurological disorders and treatments
- Single-cell and spatial transcriptomics
- Pregnancy and preeclampsia studies
- Microbial infections and disease research
- GDF15 and Related Biomarkers
- Immune cells in cancer
- Gallbladder and Bile Duct Disorders
- Autophagy in Disease and Therapy
- Biosensors and Analytical Detection
- Spaceflight effects on biology
- Wireless Networks and Protocols
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- interferon and immune responses
- Congenital heart defects research
Soochow University
2020-2025
Nanjing Medical University
2022-2024
State Key Laboratory of Reproductive Medicine
2024
Lianyungang Maternal and Children’s Hospital
2022-2023
Shandong University of Traditional Chinese Medicine
2022
Shandong Provincial QianFoShan Hospital
2021
Shandong First Medical University
2021
Nanjing University of Chinese Medicine
2021
Soochow University
2012-2019
Fudan University Shanghai Cancer Center
2019
The striato-nigral (Str-SN) circuit is composed of medium spiny neuronal projections that are mainly sent from the striatum to midbrain substantial nigra (SN), which essential for regulating motor behaviors. Dysfunction Str-SN circuitry may cause a series disabilities associated with neurodegenerative disorders, such as Huntington's disease (HD). Although etiology HD known abnormally expanded CAG repeats huntingtin gene, treatment remains tremendously challenging. One possible reason lack...
Increasing numbers of refractory or severe, even fatal, cases Mycoplasma pneumoniae infections have been reported in recent years. Excessive inflammatory responses play a vital role the pathogenesis M. pneumonia (RMPP). HMGB1 is an actively secreted cytokine produced by macrophages and other cells that participates various infectious diseases. The present study aimed to explore clinical significance children with RMPP potential mechanism expression. Four hundred fifty-two diagnosed...
Abstract Human stem cells and derivatives transplantation are widely used to treat nervous system diseases, while the fate determination of transplanted is not well elucidated. To explore cell changes human brain organoids before after transplantation, into prefrontal cortex (PFC) hippocampus (HIP), respectively. Single‐cell sequencing then performed. According time‐series sample comparison, mainly undergo neural development at 2 months post‐transplantation (MPT) glial 4MPT, A different...
<title>Abstract</title> Objective To develop an interpretable machine learning (ML) model for predicting severe <italic>Mycoplasma pneumoniae</italic> pneumonia (SMPP) in order to provide reliable factors the clinical type of disease. Methods We collected data from 483 school-aged children with <italic>M. (MPP) who were hospitalized at Children's Hospital Soochow University between September 2021 and June 2024. Difference analysis univariate logistic regression employed identify predictors...
Electrochemical cytometry based on nano-tip microelectrodes was used to quantify the vesicular storage at single-cell level in human neurons and midbrain organoids which acted as disease models of young-onset Parkinson's (YOPD). Human dopaminergic (DA) were derived from an induced pluripotent stem cell line one YOPD patient. We show a significant deficiency catecholamine slower pore forming process surface microelectrode DA The upregulation α-synuclein both patient is associated with...
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia in children. However, its mechanism pathogenesis not fully understood, and microRNAs might play role. This study aimed to explore the microRNA-222-3p (miR-222-3p) expression possible role children with M.pneumoniae (MPP).Thirty-six MPP twenty-seven age-matched controls from Children's Hospital Soochow University were enrolled this study. MiR-222-3p cluster differentiation 4 (CD4) mRNA detected using real-time PCR...
Abstract Recurrent spontaneous abortion (RSA) is a common complication of early pregnancy. Dendritic cells (DCs) are thought to confer fetal–maternal immunotolerance and play crucial role in ensuring successful A decrease plasmacytoid dendritic (pDCs) was found be involved RSA, but the underlying mechanisms decreased pDC RSA remain unclear. MicroRNAs (miRNAs) critical roles as well development, differentiation functional regulation pDCs; however, regulatory effect miRNAs on has not been...
Nasopharyngeal carcinoma (NPC) is a malignant tumor that commonly occurs in southern China and Southeast Asia. Radiation therapy the main treatment for patients with NPC, radioresistance of NPC an unresolved clinical problem. This study focuses on mechanism explores therapeutic targets research directions increasing radiosensitivity radioresistant cells.We used gradient dose model to establish strains 6-10B CNE-2 human cells. Plate colony formation assays were verify We evaluated expression...
Background: Respiratory syncytial virus (RSV) can cause varying degrees of lung inflammation in children. Qingfei Oral Liquid (QF) is effective treating childhood RSV-induced (RSV-LI) clinics, but its pharmacological profiles and mechanisms remain unclear. Methods: This study combined network Pharmacology, lipidomics, pharmacodynamics, pathway validation to evaluate the therapeutic QF. Using Cytoscape (v3.8.2) enrichment analyses from Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology...
Preeclampsia (PE) is a multisystemic and placental inflammatory disease that causes maternal infant health issues. As one of the active components in peony root extract, paeonol (Pae) exerts anti-apoptosis anti-inflammatory effects. Nonetheless, protective role Pae PE has not yet been characterized. A mouse model was constructed through tail vein injection 1 mg/d phosphatidylserine/dioleoyl-phosphatidycholine suspension. The levels cytokines placenta were examined via enzyme-linked...
Abstract Autism spectrum disorder (ASD), which is caused by heterogeneous genetic and environmental factors, characterized diverse clinical phenotypes linked to distinct pathological mechanisms. ASD individuals with a shared phenotype might contribute revealing the molecular mechanism underlying progression. Here, it generated induced pluripotent stem cell (iPSC)‐derived cerebral organoids from normocephalic in prospective birth cohort diagnosis. Multiple lines time series scRNA‐seq combined...
<title>Abstract</title> Background : Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory illness in children, particularly those with allergic constitutions. NK cells and cytokines are thought to be involved; however, understanding of the immunopathology MPP incomplete. Methods Peripheral blood samples were collected from 51 children hospitalized MPP, 26 an constitution 25 without, 29 healthy controls. cell subsets analyzed by flow cytometry expression interleukin (IL)-1 alpha...
Abstract Background Children with Mycoplasma pneumoniae pneumonia (MPP) exhibit decreased CD47 expression, which correlates disease. expression is suppressed by miR-222-3p, elevated in MPP, and interaction receptor SIRPα promotes phagocytosis. We hypothesized that contributes to the development of MPP. Methods Ninety-three children hospitalized at Children’s Hospital Soochow University requiring bronchoscopy were enrolled study; 65 diagnosed MPP (MPP group) 28 presented a bronchial foreign...
Gestational diabetes mechanism is related to lipid metabolism and insulin resistance, but its of action still needs be explored. Whether the for astragalus polysaccharides in treatment gestational above factors worth studying. 100 SD rats were this study selected, which 10 set control group, rest separated into groups, namely; positive model low-dose middle-dose high-dose group with each. AMP-activated protein kinase (AMPK) pathway inhibitor (inhibitor group) AMPK agonist (agonist then...
Background: Analyzed pathogenic bacteria isolated from bile samples of patients with biliary tract infection and their drug resistance in the first Affiliated Hospital Nanjing Medical University 2017 to 2020, so as provide evidence for treatment infection. Methods: Clinical strains specimens suspected First 2020 were collected, The susceptibility criteria are based on standards published by National Standardization Committee US Laboratories. WHONET 5.6 software was used analyze distribution...