A5115602334- Neurological Disease Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- Microbial infections and disease research
- Ginkgo biloba and Cashew Applications
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Chromatography in Natural Products
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Acupuncture Treatment Research Studies
- melanin and skin pigmentation
- Neonatal Respiratory Health Research
- Sex work and related issues
- S100 Proteins and Annexins
- Freezing and Crystallization Processes
- Tuberculosis Research and Epidemiology
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Thermal Regulation in Medicine
- Biosensors and Analytical Detection
- Bioinformatics and Genomic Networks
Chinese Institute for Brain Research
2021-2025
Beijing University of Chinese Medicine
2021-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022-2025
Xuchang University
2024
Ningbo Center for Disease Control and Prevention
2019-2023
Shaanxi University of Science and Technology
2023
Zhongnan Hospital of Wuhan University
2022-2023
Wuhan University
2022-2023
Beijing Technology and Business University
2023
Center for Disease Control
2023
To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in treatment patients with moderate coronavirus disease 2019 (COVID-19).We prospectively enrolled 30 treatment-naïve confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. The were randomized 1：1 to HCQ group control group. Patients given 400 mg per day for 5 days plus conventional treatments, while those only. primary endpoint was negative conversion rate SARS-CoV-2 nucleic acid respiratory...
Objectives: This observational study was conducted to investigate capillary refill time (CRT) during the early phase of ICU admission in relationship with microvascular flow alteration and outcome critically ill patients. Design: Prospective, observational, pilot study. Setting: a university hospital. Patients: Two hundred eighty-two adult patients admitted ICU. Interventions: None. Measurements Main Results: All underwent simultaneous measurements by CRT sidestream dark field imaging within...
Non-alcoholic fatty liver disease (NAFLD) is a prevalent associated with lipotoxicity, lipid peroxidation, oxidative stress, and inflammation. Nuciferine, an active ingredient extracted from the natural lotus leaf, has been reported to be effective for prevention treatment of NAFLD. Per-Arnt-Sim kinase (PASK) nutrient responsive protein that regulates glucose metabolism, mitochondrial respiration, gene expression. The aim present study was investigate protective effect nuciferine against...
Objective To assess the prevalence of HIV infection and characteristically risk factors which associated with among MSM in Harbin, China. Methods A face-to-face questionnaire interview was conducted 463 Men Who Have Sex (MSM) who were recruited by snowball sampling Harbin from April, 2011 to July, 2011. The mainly included demographics, AIDS knowledge, homosexual behavior status intervention MSM. Blood specimens obtained tested for diagnoses HIV, syphilis hepatitis C virus (HCV)....
Sepsis patients with diabetes are at a high clinical risk. It is well reported that XueBiJing injection has good benefit in sepsis individuals. However, there no relevant report about the efficacy and safety of XBJ comorbid diabetes. Data two large randomized controlled trials (XBJ-SAP (ChiCTR-TRC-13003534) EXIT-SEP (NCT0323874)) were combined, post hoc analyses performed. further divided into XBJ-treated group placebo based on inclusion exclusion criteria. The primary (28-day mortality)...
Skeletal muscle dysfunction caused by obesity is characterized the decline in mitochondrial content and function. 5-Heptadecylresorcinol (AR-C17) a specific bioactive component derived from whole wheat rye, which has been evidenced to improve obesity-associated skeletal dysregulation. However, mechanism underlying its protective activity requires further exploration. Herein, we found that AR-C17 (5, 10, 20 μM) intervention reversed PA-induced (0.5 mM) reduction content, membrane potential,...
Abstract Human rhinovirus B (HRV-B) is a major human viral pathogen that can be responsible for various kinds of infections. Due to the health risks associated with HRV-B, it therefore crucial explore rapid, specific, and sensitive method surveillance. Herein, we exploited novel detection HRV-B by combining reverse-transcription recombinase polymerase amplification (RT-RPA) nucleic acids isothermal trans-cleavage activity Cas12a. Our RT-RPA-Cas12a-based fluorescent assay completed within...
To examine differences in the plasma levels of miRNA-21, - 214, -34a, and -200a patients with persistent high-risk human papillomavirus (hr-HPV) infection or cervical lesions different grades.Venous blood was collected from 232 individuals to measure expression -200a. The subjects included normal controls hr-HPV infection, CIN1, CIN2, CIN3, cancer (n = 42, 31, 19, 54, 71, 15 patients, respectively). Cervical conization specimens were all women. ensure accuracy histopathology, three...
A 2-dose varicella vaccine immunization strategy has been implemented in many cities China, but there is few evidence on a long-term evaluation of the efficacy from China. This study aims to assess two doses and analysis its influencing factors. retrospective was carried out 837,144 children born between 2011 2017 Ningbo, Easten The logistic regression performed estimate effectiveness (VE). overall VE 2 compared without 90.31% (89.24-91.26%), incremental 1-dose 64.71% (59.92-68.93%)....
Uncorrected refractive error is the leading cause of global vision impairment (Bourne et al. 2013), with myopia being most frequently seen error, especially in east and southeast Asian countries (Morgan 2012). It reported that prevalence estimated to reach 49.8% worldwide by 2050 (Holden 2016). had been shown previous studies changes continued from childhood into adulthood. Thus, understanding trend rate children adolescents important be able provide eye care needs perhaps control diseases...
Elderly patients with ischemic stroke (IS) have worse functional outcomes and poorer quality of life after suffering a than younger patients. The identification effective agents is critical to optimizing the therapy IS in elderly To examine efficacy diterpene ginkgolides meglumine injection (DGMI) vs. Ginaton treating IS, across different age subgroups. Efficacy was determined through post hoc analysis randomized controlled study, which had cohort 998 IS. Participants were pooled grouped by...
Abstract Background In recent years, reports of refractory Mycoplasma pneumoniae pneumonia (RMPP) have gradually increased, including on how these conditions threaten the lives children. However, specific mechanism (MPP) remains unclear. This study aimed to investigate relationship between community-acquired respiratory distress syndrome toxin (CARDS TX) and High-mobility group box protein 1-Toll-like receptors-Myeloid differentiation factor 88 (HMGB1-TLRs-MyD88) in MPP examine immune...
Abstract Influenza A viruses (IAV) initiate infection via binding of the viral hemagglutinin (HA) to sialylated glycan receptors on host cells. HAs receptor specificity towards sialic acid (SA) is well studied and clearly critical for virus infection, but contribution highly complex cellular plasma membrane remains elusive. In addition, some studies indicated that other cell factors such as epidermal growth factor might contribute initial virus-cell contact further downstream signaling 1 ....
This study aimed to extend the storage time of fresh-cut lotus roots. A quantitative evaluation was conducted using grey-correlation analysis method based on variation-coefficient weight observe treatment acetic acid (0, 2%, and 5%) ozone 0.3 mg/L, 0.6 mg/L). Their effects loss rate, browning degree, content reducing sugar, ascorbic acid, free amino were determined. Under varied treatments time, nutritional components in root differed. Result weighted correlation degree showed that for...
The aim of this study was to predict the kinase inhibitors that may regulate autophagy. A total 62 kinases were obtained through text mining by importing keyword 'autophagy' and a 'protein kinase' Excel file PubMed. Subsequently, 146 derivated screening in PubMed database 'autophagy‑associated gene' files. Following intersection above two methods, 54 candidate autophagy‑associated obtained. Enrichment analysis indicated these mainly enriched pathways such as calcium, Wnt, HIF‑1 mTOR...
Due to limited time windows and technical requirements, only a small percentage of patients can receive reperfusion therapy for acute ischemic stroke (AIS). Previous studies have shown that LongShengZhi (LSZ) capsule improve neurological outcomes in after AIS, yet those results not been finally verified through rigorous randomized controlled trials. Thus, this trial was designed further clarify the efficacy safety LSZ with AIS.
The varicella-zoster virus (VZV) infection causes central vasculopathy, and then leads to stroke onset. This article reviews the correlation between VZV onset in order conduct a comprehensive assessment of patients with infection, thereby reducing risk after infection. Key words: Herpesvirus 3, Human; Herpes Zoster; Chickenpox; Virus Activation; Stroke; Risk Factors
Abstract Human rhinovirus B (HRV-B) is a major human viral pathogen that can be responsible for various kinds of infections. Due to the health risks associated with HRV-B, it therefore crucial explore rapid, specific, and sensitive method water quality surveillance. Herein, we exploited novel detection HRV-B by combining reverse-transcription recombinase polymerase amplification (RT-RPA) nucleic acids isothermal trans-cleavage activity Cas12a. Our RT-RPA-Cas12a-based fluorescent assay...
Objective: To analyze the occupational health surveillance data of toxic and harmful workers in Ningbo, provide scientific basis for making protective measures. Methods: export reported by examination institutions Ningbo during January 1, 2011 to December 31, 2017 from China Information System Disease Control Prevention, trend suspected disease contraindication detection rate, compare status different industry nature, economic type, enterprise scale hazards. Results: From 2017, number was...