A5100461331- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Respiratory and Cough-Related Research
- Microbial infections and disease research
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Luminescence and Fluorescent Materials
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Neonatal Health and Biochemistry
- RNA Interference and Gene Delivery
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Nanoplatforms for cancer theranostics
- Cytomegalovirus and herpesvirus research
- Axial and Atropisomeric Chirality Synthesis
Soochow University
2016-2025
Wannan Medical College
2025
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Heilongjiang University of Chinese Medicine
2025
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Soochow University
2014-2024
Peking University
2024
Peking University Third Hospital
2024
Reactive oxygen species (ROS) have been implicated as a signal for general autophagy. Both mitochondrial-produced and exogenous ROS induce autophagosome formation. However, it is unclear whether are required the selective autophagic degradation of mitochondria, process called mitophagy. Recent work using carbonyl cyanide m-chlorophenylhydrazone (CCCP), mitochondrial-uncoupling reagent, has shown to CCCP treatment may not be biologically relevant since causes depolarization entire...
Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate selection mediated ubiquitination recruitment of ubiquitin-binding autophagic receptors such as p62, NBR1, NDP52 Optineurin. Although it has been shown that these act cooperatively to target some types substrates nascent autophagosomes, their precise roles not well understood. Here, we examined selective degradation peroxisomes...
The selective degradation of mitochondria by the process autophagy, termed mitophagy, is one major mechanisms mitochondrial quality control. best-studied mitophagy pathway mediated PINK1 and PARK2/Parkin. From recent studies it has become clear that ubiquitin-ligation plays a pivotal role most focus been on ubiquitination proteins in mitophagy. Even though reversible process, very little known about deubiquitinating enzymes (DUBs) Here, we report 2 DUBs, USP30 USP35, regulate PARK2-mediated...
The purpose of this study was to explore the clinical and laboratory characteristics children with refractory Mycoplasma pneumoniae pneumonia (RMPP).Seventy-six RMPP 26 non-refractory M. (NRMPP), confirmed by both serology fluorescent quantitation PCR in bronchoalveolar lavage fluid (BALF), were evaluated retrospectively.Compared those NRMPP, older (66.6±39.0 vs. 48.4±35.4 months, p=0.038) had a longer duration fever (12.7±2.6 7.5±1.8 days) hospital stay (12.1±3.2 7.4±2.9 days). Children...
Compelling evidence has demonstrated that macroautophagy/autophagy plays an important role in regulating multiple steps of metastatic cascades; however, the precise autophagy metastasis remains unclear. This study demonstrates inhibition induced by MCOLN1/TRPML1 suppresses cancer evoking ROS-mediated TP53/p53 pathway. First, we found MCOLN1-mediated not only profoundly inhibits both migration and invasion malignant melanoma glioma cell lines vitro, but also vivo. Second, our reveals MCOLN1...
Co-infections are common in childhood community acquired pneumonia (CAP). However, their etiological pattern and clinical impact remains inconclusive.Eight hundred forty-six consecutive children with CAP were evaluated prospectively for the presence of viral bacterial pathogens. Nasopharyngeal aspirates examined by direct immunofluorescence assay or polymerase chain reaction (PCR) viruses. PCR nasopharyngeal enzyme-linked immunosorbent assays performed to detect M. pneumoniae. Bacteria was...
The regulation of organelle abundance is critical for cell function and survival; however, the mechanisms responsible are not fully understood. In this study, we characterize a role deubiquitinating enzyme USP30 in peroxisome maintenance. Peroxisomes highly dynamic, changing response to metabolic stress. our recent study identifying mitophagy, observed be localized punctate structures resembling peroxisomes. We report here that USP30, best known as mitophagy regulator, also necessary...
Macroscopic regulation of chiral supramolecular nanostructures in liquid-crystalline block copolymers is great significance photonics and nanotechnology. Although fabricating helical phase structures via doping microphase separation has been widely reported, the memory self-recovery capacity asymmetric are major challenge still deeply rely on presence additives. Herein, we demonstrate first controllable an achiral amphiphilic copolymer consisting poly(ethylene oxide) azobenzene (Azo) groups....
Neutrophil infiltration is the characteristic pathological feature of M. pneumoniae pneumonia (MPP). This study aimed to explore associations among neutrophil activity, clinical presentation, and role pneumoniae/interleukin-8 (IL-8)/neutrophil axis in pathogenesis MPP. A total 42 patients with MPP were prospectively enrolled study. including matrix metalloproteinase-9 (MMP-9), myeloperoxidase (MPO), elastase (NE), measured. Clinical information was collected for all control group. In vitro,...
Early distinction between refractory M. pneumoniae pneumonia (RMPP) and non-RMPP (NRMPP) is still difficult. The community-acquired respiratory distress syndrome (CARDS) toxin can induce inflammatory histopathological phenotypes associated with infection. This study aimed to investigate the clinical significance of CARDS pro-inflammatory cytokines in children RMPP explore whether TNF-α expression. Levels BALF from control MPP were determined by real-time PCR ELISA, respectively. A...
Respiratory syncytial virus (RSV) is a major cause of severe health problems in newborns and young children. The protective role limitations serum maternal RSV antibodies infants under 3 months remain controversial. A two-center prospective study from 2020 to 2023 recruited (n=286) admitted the respiratory departments two children's hospitals southwestern southeastern China during epidemic. These were hospitalized with lower tract infections (LRTI). We evaluated relationship between...
The aim of this study was to investigate the clinical characteristics severe pneumonia caused by human bocavirus (HBoV) infection explore associated risk factors. We conducted a retrospective review data from children hospitalized with HBoV pneumonia. Based on severity pneumonia, patients were categorized into and non-severe groups. Clinical manifestations, laboratory examination results, chest imaging pathogens analyzed. Logistic regression employed identify factors for A total 334...
Tuning the type of solvophilic chain and length nucleating segment in polymerization-induced chiral self-assembly drives formation azobenzene liquid-crystalline block copolymer assemblies, facilitating tunable chiroptical inversions....
Abstract Background The incidence of severe acute respiratory tract infections in children caused by Mycoplasma pneumoniae (syn. Schizoplasma ) and Chlamydophila ( formerly Chlamydia varies greatly from year to place around the world. This study investigated epidemiology M . C among hospitalized with Suzhou, China 2006, associations between rates climatic conditions. Methods Nasopharyngeal aspirates obtained 1598 patients (aged 26.4 ± 28.3 months; range, 1 month 13 years) were analyzed...
MicroRNAs play roles in the pathogenesis of bronchial asthma. However, mechanism miR-29c allergic asthma remains unclear. This study is to elucidate regulation Th cell differentiation by mononuclear macrophages. A total 52 children with exacerbation and 26 as controls were enrolled study. CD14+ monocytes isolated from peripheral blood. Differential expressions microRNAs evaluated using microarray analysis expression was determined qRT-PCR. The plasma B7-H3 ELISA. Transfection studies...
Abstract To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis 396 RMPP our hospital admitted between 1 January 2011 31 December 2016 was performed. Nasal aspirate samples were collected for pathogen detection clinical data collected. We analysed characteristics, lung imaging characteristics pathogenic species among these children. Of cases, 107 (27.02%) had other pathogen, Streptococcus ,...
Abstract Objective The objective of this study was to assess epidemiological and clinical features human bocavirus (HBoV) coinfection with other viruses. Method Children coinfected HBoV between January 2012 December 2014 were enrolled retrospectively reviewed. Result A total 984 patients stratified into five groups: infection alone (n = 249), respiratory syncytial virus (RSV) 649), RSV 28), rhinovirus (HRV) 39) 19). Length hospitalization longer in group than (9.0 days vs. 7.0 days, p...