A5042640893- Urological Disorders and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal disorders and treatments
- Pediatric Urology and Nephrology Studies
- Infant Nutrition and Health
- Hernia repair and management
- Congenital gastrointestinal and neural anomalies
- Gallbladder and Bile Duct Disorders
- Minimally Invasive Surgical Techniques
- Sexual Differentiation and Disorders
- Congenital Diaphragmatic Hernia Studies
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Urologic and reproductive health conditions
- Neonatal Respiratory Health Research
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Clinical Nutrition and Gastroenterology
- Helicobacter pylori-related gastroenterology studies
- Appendicitis Diagnosis and Management
- Ureteral procedures and complications
- Central Venous Catheters and Hemodialysis
- Esophageal and GI Pathology
Chinese University of Hong Kong
2014-2025
Prince of Wales Hospital
2014-2025
Duchess of Kent Children's Hospital
2022-2025
Tuen Mun Hospital
2023
Creative Research Enterprises (United States)
2017
Prince of Wales Hospital
2016
Cornell University
2014
YangPu Geriatric Hospital
2009
Objective To report our initial experience of endoscopic dismembered pyeloplasty through a retroperitoneal approach in infants and children with pelvi‐ureteric junction (PUJ) obstruction. Patients methods Thirteen PUJ obstruction underwent retroperitoneoscopic (mean age at operation 2.7 years, range 0.25–10). Nine patients presented complications secondary to obstruction, including urinary tract infection, pyonephrosis increasing hydronephrosis impairment renal function. The other four had...
<b><i>Background:</i></b> Infants receiving prolonged parenteral nutrition (PN) are at risk of PN-associated cholestasis (PNAC). This can progress to hepatic failure and death if PN cannot be discontinued. Fish oil-based lipid preparation (FOLP) has been shown beneficial in case studies. <b><i>Objectives:</i></b> (1) To evaluate whether FOLP could halt or reverse the progression PNAC compared with soy-based (SLP) (2) assess effects on liver...
Background Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are acute conditions which could result in mortality severe morbidity preterm infants. Our objective was to identify dysregulated micro-RNAs (miRNAs) small bowel tissues of NEC SIP, their possible roles disease pathophysiology. Methods We performed differential miRNA arrays on (n = 4), SIP 4) surgical-control (Surg-CTL; n validated target miRNAs by qPCR 10 each group). The association with 52 mRNAs...
Data regarding the prevalence of constipation in general population Asian children using internationally standardized definitions are scarce. Environmental factors surrounding a child's day to living may trigger or perpetuate and encourage postponement defecation.A territory-wide cross-sectional questionnaire survey was conducted 2318 Hong Kong Chinese elementary school students. Constipation defined by pediatric Rome III criteria.The mean age 9 ± 1.9 years; 51% were boys. Two hundred...
To provide a comprehensive database of gene regulation and compare differentially regulated molecular networks in human tissues necrotizing enterocolitis (NEC) spontaneous intestinal perforation (SIP).Both NEC SIP are devastating surgical emergencies associated with high morbidity mortality preterm infants. Their pathophysiology mechanisms remain unclear.Differential whole genome microarray analysis was performed on collected from (n = 15) 12) infants compared surgical-control patients...
Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are the most common acute surgical emergencies associated with high morbidity mortality in preterm infants. We aimed to compare profiles of immunoregulatory proteins identify novel mediators plasma NEC SIP also investigated expression target genes resected tissues an enterocyte cell line. Using Cytokine Antibody Array assay, we reported first comparative infants, showed that dysregulated belonged functionally...
Prostatic utricle cyst (PUC) is known to be associated with hypospadias. We aimed investigate the prevalence of PUC in children proximal hypospadias by cystoscopy, and risk symptom development after repair. retrospectively reviewed records patients who underwent 2-stage repair for had cystoscopy assessment over period January 2017-September 2022. A total 34 penoscrotal, scrotal or perineal were included review. First-stage was performed at a median age 12 months. The ventral curvature 70...
Objective A firm diagnosis revealing the etiology of disorders/differences sex development (DSD) is most helpful in guiding clinical management. The aim this study to investigate molecular genetic diagnoses and surgical treatment a cohort children with 46,XY DSD. Methods retrospective was conducted on They were referred tertiary center during period between 2011 2022 found have alterations, which considered etiologies for their Data presentations, rearing, findings, treatment, comorbidities...
The aim of this study is to investigate the differences in characteristics between Helicobacter pylori-positive and H pylori-negative primary ulcers Chinese children.We conducted a retrospective review children with peptic ulcers. Demographic data, clinical presentations, endoscopic features, histological findings, pylori prevalence, ulcer recurrences were studied.Forty-three diagnosed over 8 years reviewed. There 31 boys 12 girls (median age years, range 3-16 years). Thirty (70%) presented...
The level of microRNA (miR)-431 was found to be markedly up-regulated in intestinal tissue necrotizing enterocolitis (NEC). objective this study identify the target gene miR-431 and investigate role miR-431-FOXA1 axis pathophysiology NEC. identified by silico prediction bioinformatics, luciferase assay, Western blotting. Effects on downstream expression signals, cell proliferation, apoptosis were investigated overexpression Caco-2 cells upon stimulation LPS or lipoteichoic acid (LTA). FOXA1...
Data of Helicobacter pylori prevalence in children and its risk factors provide clues to the health authority estimate burden H. pylori-associated diseases usually encountered adulthood facilitate healthcare planning.A cross-sectional population-based study was conducted Chinese elementary high schools. Schools were selected from all three major areas Hong Kong. infection defined by a positive (13)C-urea breath test. Study subjects stratified into six age groups for estimation prevalence....
Pediatric Rome III criteria of functional dyspepsia (FD) has eliminated the mandatory use upper endoscopy and recommended a symptom-based approach. In absence alarm symptoms, FD can be positively diagnosed in children having normal physical findings without exclusionary investigations. We aimed to investigate effectiveness guidelines discriminate organic diseases from identify predictors for positive endoscopic findings.A prospective study was conducted on consecutive fulfilling FD. Upper...
Objective To report our experience of laparoscopic excision symptomatic prostatic utricles in children. Patients and methods Prostatic were excised laparoscopically four boys (mean age 6.3 years, range 1.5–17). Cysto‐urethroscopy cannulation the utricle was initially undertaken with a cystoscope that left situ inside to facilitate subsequent identification mobilization during procedure. Laparoscopy conducted via 5‐mm port inserted through supra‐umbilical incision. Two more 5 mm working ports...
Intussusception is one of the most common causes intestinal obstruction in infancy. Non-operative reduction using air enema or other hydrostatic methods has been standard treatment cases. However, if non-operative method not indicated fails, open surgery still necessary. With tremendous development minimally invasive approach handling surgical conditions children last decade, this applied recently for intussusception children. We herein reviewed our experience combined approach, namely,...