A5086252547- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Cardiovascular Health and Disease Prevention
- Circadian rhythm and melatonin
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Sleep and Work-Related Fatigue
- Asthma and respiratory diseases
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Practices and Patient Outcomes
- Health, Environment, Cognitive Aging
- Dysphagia Assessment and Management
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
Woolcock Institute of Medical Research
2015-2024
Macquarie University
2022-2024
Royal Prince Alfred Hospital
2004-2024
Royal North Shore Hospital
2014-2023
The University of Sydney
2013-2022
Medical University of South Carolina
2022
American Thoracic Society
2022
Northern Sydney Local Health District
2017-2021
National Health and Medical Research Council
2011-2020
Kineta (United States)
2018
Rationale: Continuous positive airway pressure (CPAP) and mandibular advancement device (MAD) therapy are commonly used to treat obstructive sleep apnea (OSA). Differences in efficacy compliance of these treatments likely influence improvements health outcomes.Objectives: To compare effects after 1 month optimal CPAP MAD OSA.Methods: In this randomized crossover trial, we compared the each treatment on cardiovascular neurobehavioral outcomes.Measurements Main Results: Cardiovascular (24-h...
<h3>Rationale and objectives</h3> Impaired insulin sensitivity (ISx), increased visceral abdominal fat (VAF) liver are all central components of the metabolic syndrome characteristics men with obstructive sleep apnoea (OSA). The reversibility these observed changes continuous positive airway pressure (CPAP) treatment in OSA has not been systematically studied a randomised sham-controlled fashion. <h3>Methods</h3> 65 without diabetes who were CPAP naïve had moderate to severe (age=49±12...
Cross-sectional analyses of North American population-based cohorts and one nonsignificant longitudinal analysis have suggested that obstructive sleep apnea (OSA) is a risk factor for diabetes mellitus. However, this observation has yet to be replicated outside the USA or observed lonigitudinally.Residents Western Australian town Busselton had their OSA quantified by respiratory disturbance index (RDI) overnight in own homes (MESAM IV device). Diabetes was defined as either fasting blood...
Dyslipidemia is common in Obstructive Sleep Apnea (OSA). Postprandial lipidemia (PPL) a strong marker of cardiovascular risk. Evidence that OSA treatment improves PPL lacking.To investigate the effect continuous positive airway pressure (CPAP) on postprandial patients with obstructive sleep apnea (OSA) upper moderate or severe range.In this randomized, placebo-controlled crossover trial, we compared effects 2 months each therapeutic and placebo CPAP PPL.PPL was determined from area under...
The combination of male gender, obstructive sleep apnoea (OSA) and obesity magnifies cardiometabolic risk. There has been no systematic study evaluating whether testosterone therapy can improve health in obese men with OSA by improving body composition, visceral abdominal fat insulin sensitivity.To assess compositional effects treatment severe OSA.An 18-week randomised, double-blind, placebo-controlled parallel group trial 67 men.Participants (age=49 ± 12 years, hypopnoea index=39.9 17.7...
T his issue of the Journal Dental Sleep Medicine (JDSM) is cause for modest
There is emerging evidence that obstructive sleep apnea (OSA) a risk factor for preclinical Alzheimer's disease (AD). An American Thoracic Society workshop was convened included clinicians, basic scientists, and epidemiologists with expertise in OSA, cognition, dementia, the overall objectives of summarizing state knowledge field, identifying important research gaps, potential directions future research. Although currently available cognitive screening tests may allow identification...
Abstract Study Objectives In older adults with Alzheimer’s disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG in those mild cognitive impairment (MCI) and none its relationship cognition this at-risk population. Methods Two hundred ten (mean age = 67.0, SD 8.2 years) underwent comprehensive neuropsychological, medical, psychiatric assessment overnight polysomnography. Participants were classified as subjective (SCI; n...
Summary Obstructive sleep apnoea (OSA) is commonly associated with cardiovascular disease and sympathetic activation. However, it unclear whether this association independent of obesity to what extent treatment nasal continuous positive airway pressure (CPAP) alleviates the vascular inflammation that underpins disease. We therefore evaluated short‐term withdrawal from CPAP therapy in subjects moderate–severe OSA would result increased levels activity circulating inflammatory cytokines...
Obstructive sleep apnoea (OSA) is commonly associated with obesity and can be improved by weight loss. Changes in upper airway size related to regional fat loss may mediate the improvement OSA. This study aimed assess changes facial abdominal their association OSA improvement.Middle-aged obese men moderate-to-severe underwent a 24-week sibutramine-assisted trial. Polysomnography CT of head neck were performed at baseline 24 weeks. The lumen parapharyngeal measured image analysis...
The aim of the present study was to investigate effect continuous positive airway pressure (CPAP) treatment on regional adipose tissue distribution in patients with moderate or severe obstructive sleep apnoea. Patients received both therapeutic and sham CPAP a random order for 2 months each an intervening 1-month washout. Abdominal subcutaneous, visceral liver fat were quantified using magnetic resonance imaging (MRI) spectroscopy (MRS). Liver enzymes plasma glucose also determined....
Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from last two decades have provided evidence for causal role of OSA in development systemic hypertension. The acute physiological changes that occur during promote nocturnal hypertension and may lead to sustained daytime via pathways sympathetic activation, inflammation, oxidative stress, endothelial dysfunction. This review will hemodynamic...
Objectives Shift workers are prone to obesity and associated co-morbidities such as diabetes cardiovascular disease. Sleep restriction with shift work results in dramatic endocrine metabolic effects that predispose these adverse health consequences. While sleep has been increased caloric intake, food preference may also play a key role weight gain work. This study examined the impact of an overnight simulated night on preference. Methods Sixteen participants [mean 20.1, standard deviation...
<h3>Introduction</h3> Obstructive sleep apnoea (OSA) is associated with increased cardiovascular risk, however the mechanisms are not well established. <h3>Objectives</h3> This study aimed to determine whether treatment of OSA nasal continuous positive airway pressure (CPAP) would favourably alter coagulability across sleep–wake cycle. <h3>Methods</h3> In a randomised crossover trial, 28 patients received therapeutic or placebo CPAP, each for 2 months 1 month washout between treatments....
Mandibular advancement splints (MAS) are often preferred to CPAP treatment for OSA but not always equally efficacious. High therapeutic pressure has been associated with MAS failure in a Japanese population. We sought assess the relationship between and response an Australian population.Therapeutic were obtained from one-month crossover trial of both treatments. Predictive utility identify was assessed.Seventy-eight patients included (age 49.3 ± 11.1 years, BMI 29.1 5.8 kg/m(2))...
Aim: To observe the effect of constant positive airway pressure (CPAP) therapy on regional lipid deposition, muscle metabolism and glucose homeostasis in obese patients with obstructive sleep apnoea syndrome (OSAS). Methods: A total 29 underwent assessment before after a minimum 12‐week CPAP therapy. Abdominal adipose tissue was assessed using magnetic resonance imaging. Intramyocellular (IMCL) skeletal creatine were 1 H‐magnetic spectroscopy. Fasting venous arterial blood collected. Glucose...
Circadian clocks regulate the daily timing of many our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in cell count, synthesis cytokine release, clock gene expression cells organs as well clock-controlled genes that function. disruption leads to dysregulation responses inflammation which can further disrupt rhythms. response organisms challenges, such allergic reactions vary depending on time day, lead detrimental particularly...