A5103184639- Hormonal and reproductive studies
- Obstructive Sleep Apnea Research
- Sexual Differentiation and Disorders
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Reproductive Health and Contraception
- Sperm and Testicular Function
- Sleep and Wakefulness Research
- Ovarian function and disorders
- Muscle metabolism and nutrition
- Estrogen and related hormone effects
- Sexual function and dysfunction studies
- Stress Responses and Cortisol
- Pharmacology and Obesity Treatment
- Hormonal Regulation and Hypertension
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Regulation of Appetite and Obesity
- Male Reproductive Health Studies
- Dietary Effects on Health
- Growth Hormone and Insulin-like Growth Factors
- Obesity, Physical Activity, Diet
- Spaceflight effects on biology
- Adipose Tissue and Metabolism
UCLA Medical Center
2015-2025
Harbor–UCLA Medical Center
2016-2025
University of California, Los Angeles
2005-2022
Los Angeles Medical Center
2005-2020
The Lundquist Institute
2010-2020
Mayo Clinic
2004-2018
Biomed Research Institute
2018
Healthy African American Families II
2018
Charles R. Drew University of Medicine and Science
2018
Olive View-UCLA Medical Center
2018
Previously published cohort studies in clinical populations have suggested that obstructive sleep apnea (OSA) is a risk factor for mortality associated with cardiovascular disease. However, it unknown whether an independent all-cause community-based sample free from referral bias. Residents of the Western Australian town Busselton underwent investigation home monitoring device (MESAM IV). OSA was quantified via respiratory disturbance index (RDI). Mortality status determined 397/400...
Androgen therapy may precipitate obstructive sleep apnea in men. Despite increasing androgen use older men, few studies have examined and breathing. Randomized, double-blind, placebo-controlled examining effects of testosterone simultaneously on sleep, breathing, function men are not available. Seventeen community-dwelling healthy over the age 60 yr were randomized to receive three injections im esters at weekly intervals (500 mg, 250 mg) or matching oil-based placebo then crossed other...
Long-term glucocorticoid therapy in men is associated with loss of bone and muscle mass as well a decrease serum testosterone. We tested the effect two androgens, testosterone its minimally aromatizable analog nandrolone, on (dual x-ray absorptiometry), strength (knee flexion extension by isokinetic dynamometry), mineral density (BMD), quality life (Qualeffo-41 questionnaire) 51 mean daily prednisone dose 12.6 +/- 2.2 mg. Men were randomized, double blind, to (200 mg mixed esters),...
The induction of spermatogenesis and fertility with gonadotropin therapy in gonadotropin-deficient men varies rate extent. Understanding the predictors response would inform clinical practice but requires multivariate analyses sufficiently large cohorts that are suitably detailed frequently assessed.A total 75 men, 72 desiring fertility, was treated at two academic andrology centers for a 116 courses from 1981-2008.Semen analysis testicular examination were performed every 3 months.A 38...
Sleep restriction is associated with development of metabolic ill-health, and hormonal mechanisms may underlie these effects. The aim this study was to determine the impact short term sleep on male health, particularly glucose metabolism, by examining adrenocorticotropic hormone (ACTH), cortisol, glucose, insulin, triglycerides, leptin, testosterone, sex binding globulin (SHBG).
<h3>Rationale and objectives</h3> Impaired insulin sensitivity (ISx), increased visceral abdominal fat (VAF) liver are all central components of the metabolic syndrome characteristics men with obstructive sleep apnoea (OSA). The reversibility these observed changes continuous positive airway pressure (CPAP) treatment in OSA has not been systematically studied a randomised sham-controlled fashion. <h3>Methods</h3> 65 without diabetes who were CPAP naïve had moderate to severe (age=49±12...
Cross-sectional analyses of North American population-based cohorts and one nonsignificant longitudinal analysis have suggested that obstructive sleep apnea (OSA) is a risk factor for diabetes mellitus. However, this observation has yet to be replicated outside the USA or observed lonigitudinally.Residents Western Australian town Busselton had their OSA quantified by respiratory disturbance index (RDI) overnight in own homes (MESAM IV device). Diabetes was defined as either fasting blood...
WHO studies provided proof of concept for hormonal male contraception using a prototype androgen-alone regimen. Combined testosterone plus progestin regimens offer more practical promise, but no contraceptive efficacy have been completed. The objective this study was to establish the principle depot androgen/progestin combination as contraceptive. We performed 55 healthy men in stable fertile relationships seeking change method. Testosterone (four 200-mg implants, every 4 or 6 months) and...
Dyslipidemia is common in Obstructive Sleep Apnea (OSA). Postprandial lipidemia (PPL) a strong marker of cardiovascular risk. Evidence that OSA treatment improves PPL lacking.To investigate the effect continuous positive airway pressure (CPAP) on postprandial patients with obstructive sleep apnea (OSA) upper moderate or severe range.In this randomized, placebo-controlled crossover trial, we compared effects 2 months each therapeutic and placebo CPAP PPL.PPL was determined from area under...
The combination of male gender, obstructive sleep apnoea (OSA) and obesity magnifies cardiometabolic risk. There has been no systematic study evaluating whether testosterone therapy can improve health in obese men with OSA by improving body composition, visceral abdominal fat insulin sensitivity.To assess compositional effects treatment severe OSA.An 18-week randomised, double-blind, placebo-controlled parallel group trial 67 men.Participants (age=49 ± 12 years, hypopnoea index=39.9 17.7...
High doses of short-term testosterone have been shown to acutely worsen sleep-disordered breathing in men with obstructive sleep apnoea (OSA). The effects lower, near-conventional obese OSA may differ over the longer term but not systematically studied. We assessed and treatment as an adjunct weight loss severe OSA.An 18-week randomized, double-blind, placebo-controlled, parallel group trial 67 men.All subjects were placed on a hypocaloric diet then received intramuscular injections 1000 mg...
<h3>Importance</h3> Severely energy-restricted diets are the most effective dietary obesity treatment. However, there concerns regarding potential adverse effects on body composition. <h3>Objective</h3> To compare long-term of weight loss via severe vs moderate energy restriction lean mass and other aspects <h3>Design, Setting, Participants</h3> The Type Energy Manipulation for Promoting Optimum Metabolic Health Body Composition in Obesity (TEMPO) Diet Trial was a 12-month, single-center,...
Summary Objective Acutely restricting sleep worsens insulin sensitivity in healthy individuals whose usual is normal duration and pattern. The effect of recovery or weekend ‘catch‐up’ on metabolically active hormones with chronic restriction who regularly at weekends as yet unstudied. Design 19 men (mean ± SEM age 28·6 2·0 years, BMI 26·0 0·8 kg/m 2 ) least 6 months’ history (5·1 0·9 years) lifestyle‐driven, restricted during the working week (373 6·6 min/night) regular (weekend extension...
Abstract Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate associations top two SDB PCs with serum levels 617 metabolites, in both single-metabolite analysis, and joint penalized regression analysis. The discovery includes 3299 individuals, validation...
Abstract Background: Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time. Objective: The objective of the study was to quantify longitudinally change serum and SHBG with age two well-defined, but geographically widely separated regional Australian cohorts. Subjects Setting: Busselton cohort comprises individuals aged 18–90 yr residing Western Australia...
Male hormonal contraceptive methods require effective suppression of sperm output.
Controversy exists over the association of estrogen and cardiovascular disease. Estrogen receptors (ERs) alpha beta are expressed in endothelial cells vascular smooth muscle (VSMCs) many arteries, but relative importance ERalpha or ERbeta mediating response to estrogens is not well defined, particularly humans. We have shown previously that postmenopausal women receiving hormone therapy (HT) had lower mean coronary artery calcium, plaque area, calcium-to-plaque ratio compared with untreated...
The aim of the present study was to investigate effect continuous positive airway pressure (CPAP) treatment on regional adipose tissue distribution in patients with moderate or severe obstructive sleep apnoea. Patients received both therapeutic and sham CPAP a random order for 2 months each an intervening 1-month washout. Abdominal subcutaneous, visceral liver fat were quantified using magnetic resonance imaging (MRI) spectroscopy (MRS). Liver enzymes plasma glucose also determined....