A5029568279- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Ovarian function and disorders
- Reproductive Health and Contraception
- Pharmacology and Obesity Treatment
- Muscle metabolism and nutrition
- Hypothalamic control of reproductive hormones
- Doping in Sports
- Estrogen and related hormone effects
- Pharmacological Effects and Assays
- Sexual function and dysfunction studies
- Prostate Cancer Treatment and Research
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Male Breast Health Studies
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Male Reproductive Health Studies
- Urinary Bladder and Prostate Research
- Blood groups and transfusion
- Menopause: Health Impacts and Treatments
- Microscopic Colitis
- Testicular diseases and treatments
University of Washington
2015-2024
Austin Health
2024
The University of Melbourne
2024
University of Cambridge
2023
University of Washington Medical Center
1995-2021
Seattle University
2020-2021
University of Dundee
2020
Harvard University
2017
National Institutes of Health
2015
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015
Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass.These changes might improve physical performance strength; however, it has not been established whether improves functional outcome men.Moreover, concerns exist about the impact of on prostate men.The administration finasteride (F), which partially blocks conversion to more potent androgen, dihydrotestosterone, attenuates replacement size prostate-specific antigen.We hypothesized...
Older men, particularly those with low serum testosterone (T) levels, might benefit from T therapy to improve bone mineral density (BMD) and reduce fracture risk. Concerns exist, however, about the impact of on prostate in older men. We hypothesized that combination finasteride (F), a 5α-reductase inhibitor, increase BMD men without adverse effects prostate. Seventy aged 65 yr or older, less than 12.1 nmol/liter two occasions, were randomly assigned receive one three regimens for 36 months:...
Low testosterone levels in men have been associated with increased mortality. However, the influence of treatment on mortality low is not known. The objective study was to examine association between and levels. This an observational testosterone-treated compared untreated men, assessed time-varying, adjusted Cox proportional hazards regression models. Effect modification by age, diabetes, coronary heart disease tested a priori. conducted clinical database that included seven Northwest...
Objective To evaluate copper, zinc, manganese, magnesium, and other indices of peroxidative status in diabetic nondiabetic human subjects. Research Design Methods Convenience sample 57 insulin-dependent or non-insulin-dependent subjects recruited from the diabetes clinic University California, Davis, Medical Center 28 staffs Departments Internal Medicine Nutrition. Individuals conducting laboratory analyses were blind to subject group. A fasting blood was collected all appropriately...
Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT).Because androgens essential for fertility, we sought to determine the impact 5ARI administration on testosterone (T), DHT, spermatogenesis. DESIGN, SETTING, SUBJECTS, AND INTERVENTION: We conducted a randomized, double-blinded, placebo-controlled trial in 99 healthy men randomly assigned receive dutasteride (D; 0.5 mg) (n = 33), (F; 5 34), or placebo 32) once...
Studies using high dose testosterone (T) administration in normal men as a male contraceptive have resulted azoospermia rates of only 50-70%. Previous studies T and progestogen combinations shown comparable azoospermia, but been uncontrolled or used doses less than that associated with maximal suppression sperm production. We conducted randomized, placebo-controlled, single blind trial comparing 6 months enanthate (100 mg, im, weekly) the same conjunction levonorgestrel (LNG; 500 micrograms,...
Summary Objective Total testosterone concentrations are influenced by sex hormone‐binding globulin ( SHBG ) concentrations, which decreased obesity and increased with ageing. Therefore, we sought to understand compare the associations of ageing . Design We performed a retrospective, cross‐sectional analysis age on measurements in men being evaluated for hypogonadism. Patients, Measurements Analysis A total 3671 who underwent laboratory testing deficiency from Veterans Administration Puget...
Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes thought influence insulin sensitivity. In this study, we sought determine whether experimental alterations in serum T change adiponectin levels normal men. We measured 28 healthy ages 18-35 years before during treatment with a potent gonadotropin-releasing-hormone (GnRH) antagonist, acyline. Decreased led increased within 7 days; maximal were reached on day 21...
ABSTRACT: Intratesticular testosterone (ITT) is thought to play a key role in the control of spermatogenesis man but rarely measured. The purposes this study were 1) examine relationship between intratesticular fluid and serum (T) at baseline during treatment with contraceptive regimen known suppress 2) measure androgenic bioactivity. Seven men received 6 months T enanthate (TE) 100 mg weekly intramuscularly plus levonorgestrel (LNG) 62.5 or 31.25 μg orally daily. Testicular was obtained by...
In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum (T), suggesting that high ITT is needed relative T for normal spermatogenesis in men. However, the quantitative relationship between and not known. To begin address this issue experimentally, we determined dose-response human chorionic gonadotropin (hCG) ascertain minimum dose maintain range. Twenty-nine men with reproductive physiology were...
Male hormonal contraceptive methods require effective suppression of sperm output.
The influence of testosterone on risk for cardiovascular events in men is uncertain. Previous observational studies sex hormones and incident disease have reported inconsistent findings, limited by cohort sizes different selection criteria.To analyze associations serum total hormone-binding globulin (SHBG) with men.Cohort study.UK Biobank prospective cohort.Community-dwelling aged 40 to 69 years.Testosterone SHBG were assayed, free was calculated. Cox proportional hazards regression done,...
Studies using exogenous high-dosage testosterone (T) or a combination regimen of physiologic T plus levonorgestrel (LNG) administration in normal men have shown that oligoazoospermia (<3 million/mL) azoospermia can be achieved the majority men. However, these hormonal regimens been associated with significant weight gain and suppression serum high-density lipoprotein (HDL) cholesterol levels. We hypothesized lower dosage LNG would result uniform severe but cause fewer adverse metabolic side...
Dutasteride and finasteride are 5alpha-reductase inhibitors that dramatically decrease serum levels of dihydrotestosterone. Because androgens affect bone, lipids, hematopoiesis, prostate sexual function, we determined the impact on these end points.We conducted a randomized, double-blinded, placebo controlled trial 99 men 18 to 55 years old randomly assigned receive 0.5 mg dutasteride (33), 5 (34) or (32) daily for 1 year. Bone mineral density was measured at baseline, after year treatment 6...
Abstract Background Novel male‐based contraceptives are needed to broaden family planning choices. A progestin, Nestorone ® (Nes) gel, plus a testosterone (T) gel suppresses sperm concentrations levels associated with effective contraception in normal men. However, administration of two gels on different parts the body daily is impractical. Objective Compare effectiveness application single, combined 8.3 mg Nes‐62.5 T (Nes‐T) vs. 62.7 suppress serum FSH and LH ≤1.0 IU/L (a threshold...
Serum testosterone concentrations decline with age, while serum sex hormone-binding globulin (SHBG) increase.To analyze associations of baseline and SHBG concentrations, calculated free (cFT) values, all-cause cause-specific mortality in men.The UK Biobank prospective cohort study community-dwelling men aged 40-69 years old, followed for 11 years.All-cause, atherosclerotic cardiovascular disease (CVD) cancer-related mortality. Cox proportional hazards regression was performed, adjusting...
Exogenous androgens plus progestins can be used to suppress spermatogenesis, resulting in effective male hormonal contraception; however, induction of azoospermia require 3-6 months, and these methods injectable or implantable androgens. We hypothesized that testosterone (T) transdermal gel (T gel) could combined with a depot formulation the progestin, depomedroxyprogesterone acetate (DMPA), without potent GnRH antagonist, acyline, spermatogenesis conveniently, rapidly, reversibly.The...