A5091344026- Hormonal and reproductive studies
- Prostate Cancer Treatment and Research
- Growth Hormone and Insulin-like Growth Factors
- Muscle metabolism and nutrition
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Pharmacology and Obesity Treatment
- Doping in Sports
- Diabetes Treatment and Management
- Antioxidant Activity and Oxidative Stress
- Sports Performance and Training
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Hypothalamic control of reproductive hormones
- Cancer Risks and Factors
The University of Western Australia
2015-2021
Fiona Stanley Hospital
2015-2020
Diabetes Australia
2016
Context Thyroid hormones modulate proliferative, metabolic and angiogenic pathways. However few studies have examined associations of thyroid with cancer risk. Objectives To explore thyrotropin (TSH), free thyroxine (FT4) anti-thyroperoxidase antibodies (TPOAb) the incidence all (non-skin) cancers specific common cancers. Design setting A prospective cohort study a community-dwelling population aged 25–84 years in Western Australia. Main outcome measures Archived sera from 3649 participants...
Serum testosterone concentrations decline with age, while serum sex hormone-binding globulin (SHBG) increase.To analyze associations of baseline and SHBG concentrations, calculated free (cFT) values, all-cause cause-specific mortality in men.The UK Biobank prospective cohort study community-dwelling men aged 40-69 years old, followed for 11 years.All-cause, atherosclerotic cardiovascular disease (CVD) cancer-related mortality. Cox proportional hazards regression was performed, adjusting...
Lower testosterone (T) is associated with poorer health outcomes in older men, however, the relationship between T, dihydrotestosterone (DHT) and estradiol (E2) cardiovascular disease (CVD) younger to middle-aged men remains unclear.We assessed associations endogenous sex hormones mortality (all-cause CVD) CVD events, a cohort of aged 17-97 years.Sex were assayed using mass spectrometry 2143 from 1994/5 Busselton Health Survey. Outcomes December 2010 analysed.Of 1804 included analysis, mean...
Clarifying the relationship of sex hormones to preclinical atherosclerosis could illuminate pathways by which androgens are associated with cardiovascular events and mortality. Our aim was determine hormone profiles carotid intima-media thickness (CIMT) atheroma, in men without known coronary artery disease (CAD). We included 492 community-based aged 20-70 years (Group A) 426 angiographically proven CAD <60 B). Fasting early morning sera were assayed for testosterone (T), dihydrotestosterone...
As men age, serum testosterone (T) concentrations decrease, as do fitness, strength, and lean mass. Whether treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged remains unclear. We assessed the effects of T exercise, alone combination, on aerobic capacity (V̇o2peak), body composition, muscular strength 50-70 yr, waist circumference ≥95 cm low-normal (6-14 nmol·L-1). Participants (n = 80) were randomized AndroForte5...
Summary Objective Insulin‐like growth factor 1 ( IGF 1) has anabolic and growth‐promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating is bound binding proteins, which modulate bioavailability of 1. This study assessed the associations proteins IGFBP 3 3) with cancer risk. Design A prospective cohort 4042 men aged ≥70 years. Methods Plasma total 1, were measured between 2001 2004. Cancer‐related outcomes until 20 June 2013 using data linkage....
Background Despite recognised benefits of optimal glycaemic control in patients with type 1 diabetes mellitus ( T1DM ), good is still difficult to achieve, particularly for adolescents and young adults. Recognition factors that may assist early optimisation therefore important. Aims We explored associations demographic, social behavioural glycosylated haemoglobin HbA1c ) levels participants aged 18–25 years. Methods A cross‐sectional analysis was performed on adults attending a dedicated...
Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts hormones to modify CVD risk unclear.We assessed whether PA sex hormone concentrations were independently measures risk.A total 1649 men.Leisure, home, work ascertained. At baseline, serum T, dihydrotestosterone (DHT) oestradiol (E2) assayed. Men stratified into high PA+high (H/H); low (L/H); PA+low (H/L); (L/L).Mean age was 49.8...
Thyroid hormones regulate cellular survival and metabolism; however, their association with cancer incidence death has not been well explored.Our aim was to examine the relationship between thyrotropin (TSH) free thyroxine (FT4) (all cancers, prostate, colorectal lung cancer). Associations cancer-related deaths were also explored.A prospective cohort study involving community-dwelling men aged 70-89 years.Thyroid measured in 3836 2001 2004. Competing risks analyses used perform longitudinal...
Abstract Context Diabetes mellitus is conventionally associated with an increased risk of cancer; however, inverse associations diabetes prostate cancer are well described. Mechanisms unclear, although hormonal factors, including alterations in sex hormone and IGF1 concentrations due to metabolic disturbances, have been hypothesized play a role. Objective To assess hormones, IGF1, glucose, advanced glycation end products (AGEs) as potential mediators the association between cancer. Design...
PURPOSE: Male ageing is associated with increased incidence of cardiovascular disease (CVD) and lower circulating testosterone (T). However, whether physical activity (PA) interacts hormones to modify CVD risk unclear. We assessed PA sex hormone concentrations were independently measures in 1649 men. METHODS: Leisure, home, work total ascertained via questionnaire. At baseline, serum T, dihydrotestosterone (DHT) estradiol (E2) assayed. Men stratified into high PA+high (H/H); low (L/H);...