A5031242176- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Sports Performance and Training
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Physical Activity and Health
- Exercise and Physiological Responses
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Pharmacological Effects and Assays
- Mechanical Circulatory Support Devices
The University of Western Australia
2016-2024
Fiona Stanley Hospital
2016-2023
Committee on Publication Ethics
2016
Liverpool John Moores University
2016
National Health and Medical Research Council
2016
Curtin University
2016
Edith Cowan University
2016
Abstract Background Based on the largely untested premise that it is a restorative hormone may reverse detrimental impacts of aging, prescription testosterone (T) has increased in recent decades despite no new clinical indications. It apparent middle-aged and older men with low-normal serum T levels are considering supplementation as an anti-aging strategy. At same time, there evidence physical activity (PA) at historical lows Western world. In this review, we compare treatment aimed...
As men age, serum testosterone (T) concentrations decrease, as do fitness, strength, and lean mass. Whether treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged remains unclear. We assessed the effects of T exercise, alone combination, on aerobic capacity (V̇o2peak), body composition, muscular strength 50-70 yr, waist circumference ≥95 cm low-normal (6-14 nmol·L-1). Participants (n = 80) were randomized AndroForte5...
Purpose Chronic heart failure (CHF) is characterized by dyspnea and poor exercise tolerance, which decreases aerobic capacity (V˙O2peak), a measure strongly correlated with quality of life mortality. In healthy populations, eccentric (ECC) cycling can be performed at lower oxygen demand for matched workload, compared concentric (CON) cycling, but few studies have previously investigated ECC in CHF. We hypothesized that, when external workload (W), an bout would cardiorespiratory load (V˙O2)...
Abstract Context With age, testosterone (T) and physical activity levels often decline in parallel. The effect of combining T treatment exercise training on ambulatory blood pressure (ABP) is unclear. Objective To assess effects, alone combination, ABP men aged 50–70 years, waist circumference ≥ 95 cm low‐normal serum (6–14 nmol/L), without organic hypogonadism. Design A 2 × factorial randomised, placebo‐controlled study. Intervention Randomization to daily transdermal AndroForte5 ®...
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ABSTRACT Introduction In healthy individuals, cerebral blood flow (CBF) increases during exercise, but few studies have compared changes in CBF exercise patients with heart failure (HF) to controls (CTRL) or assessed the effects of left ventricular assist devices (LVAD). We hypothesized that subjects implanted LVAD would exhibit impaired cerebrovascular responses cycle when age- and sex-matched CTRL enhanced relative HF. Methods Internal carotid artery (ICA) intracranial middle (MCAv)...
Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence outcomes remains unclear. We assessed whether hormone concentrations PA were additively lower central adiposity risk.3351 community-dwelling men, mean age 77 years.Baseline testosterone (T), dihydrotestosterone (DHT) oestradiol (E2) assayed. Levels of ascertained by questionnaire. Men stratified using median splits into high + (H/H), (H/L); (L/H) (L/L)...
Middle-aged and older men have typically accumulated comorbidities, are increasingly sedentary, lower testosterone concentrations (T) compared to younger men. Reduced physical activity (PA) T both associated with, may predispose to, metabolically adverse changes in body composition, which contribute higher risks of cardiometabolic disease. Exercise improves health, but sustained participation is problematic. By contrast, rates prescription increased, particularly middle-aged without organic...
Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity decrease vascular function in healthy participants, although data CHF are scant. Eccentric (ECC) cycling is a novel modality that may be particularly suited to CHF, but the acute impacts of ECC on currently unknown. Our null hypothesis was concentric (CON) cycling, performed at...
Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts hormones to modify CVD risk unclear.We assessed whether PA sex hormone concentrations were independently measures risk.A total 1649 men.Leisure, home, work ascertained. At baseline, serum T, dihydrotestosterone (DHT) oestradiol (E2) assayed. Men stratified into high PA+high (H/H); low (L/H); PA+low (H/L); (L/L).Mean age was 49.8...
Impaired endothelial function in people with coronary heart disease (CHD) is associated increased mortality. Water immersion can increase peripheral artery shear stress which may provide an additional stimulus to the endothelium during exercise. This study compared effects of water-based circuit exercise training (WEX) and gym-based (GEX) on vascular stable CHD. Participants were randomized 12 wk WEX (n = 20), GEX or a control group (usual activities; n 12). Endothelium-dependent...
PURPOSE: Male ageing is associated with increased incidence of cardiovascular disease (CVD) and lower circulating testosterone (T). However, whether physical activity (PA) interacts hormones to modify CVD risk unclear. We assessed PA sex hormone concentrations were independently measures in 1649 men. METHODS: Leisure, home, work total ascertained via questionnaire. At baseline, serum T, dihydrotestosterone (DHT) estradiol (E2) assayed. Men stratified into high PA+high (H/H); low (L/H);...