A5101840009- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Renin-Angiotensin System Studies
- Pulmonary Hypertension Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer-related gene regulation
- Atomic and Subatomic Physics Research
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medicinal Plant Extracts Effects
- Vascular Procedures and Complications
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Studies on Chitinases and Chitosanases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemoglobinopathies and Related Disorders
- Biliary and Gastrointestinal Fistulas
- Cancer Research and Treatments
- Cardiac Structural Anomalies and Repair
- Soft tissue tumor case studies
United Christian Hospital
2005-2024
Chinese University of Hong Kong
2023
Johns Hopkins Medicine
2015-2022
Johns Hopkins University
2015-2022
Hong Kong College of Technology
2019
Castle Peak Hospital
2019
Ruttonjee Hospital
2012-2018
Rutgers New Jersey Medical School
2015
Sorbonne Université
2015
Centre National de la Recherche Scientifique
2015
The objective of this study was to evaluate the clinical safety intravenous gadolinium-based contrast media used in patients who underwent MRI at a single institution. Acute adverse reactions for Princess Margaret Hospital, Hong Kong, SAR, from January 1999 November 2004 were recorded an incidence log book. medical records patients' demographics retrospectively reviewed and nature, frequency severity investigated documented. acute 0.48% (45 with 46 reactions). these 96% mild, 2% moderate...
Bladder cancer (BCa) is the ninth most common form of in world. There a continuing need not only for improving accuracy diagnostic markers but also development new treatment strategies. Recent studies have shown that renin-angiotensin system (RAS), which include angiotensin type 1 (AT1R), 2(AT2R), and Mas receptors, play an important role tumorigenesis may guide us meeting those needs.In this study, we first observed AT1R expression levels were significantly upregulated BCa specimens while...
Little is known about the efficacy of proton pump inhibitors compared with H(2) receptor antagonists in preventing adverse upper gastrointestinal complications patients acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin thrombolytics. The objective this study was to compare efficacies esomeprazole famotidine complications.A double-blind, randomized, controlled trial performed a combination either Patients received (20 mg...
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous, heptapeptide hormone acting through the Mas receptor (MasR), with antiproliferative and antiangiogenic properties. Recent studies have shown that Ang-(1-7) has action on lung adenocarcinoma cells prostate cancer cells. In this study, we report MasR levels were significantly upregulated in nasopharyngeal carcinoma (NPC) specimens NPC cell lines. Viral vector-mediated expression of dramatically suppressed proliferation migration vitro. These...
Heart failure with preserved ejection fraction (HFpEF) continues to be a diagnostic challenge. Cardiac magnetic resonance atrial measurement, feature tracking (CMR-FT), tagging has long been suggested diagnose HFpEF and potentially complement echocardiography especially when is indeterminate. Data supporting the use of CMR measurements, CMR-FT or tagging, are absent. Our aim conduct prospective case-control study assessing accuracy volume/area, CMR-FT, amongst patients suspected having...
<h3>Background</h3> Amlodipine inhibits cytochrome P450 (CYP) enzyme and has the potential to reduce clopidogrel bioactivation in vivo. Reports previous retrospective studies described greater platelet reactivity patients on amlodipine. <h3>Objective</h3> To evaluate treatment effect of amlodipine versus not calcium-channel blockers (CCBs). <h3>Design setting</h3> Randomised, controlled, open-label trial conducted a regional acute hospital. <h3>Patients interventions</h3> 98 for ischaemic...
Gene therapy's entrance into clinical settings has made it an ever more attractive field of study for various diseases. However, relatively little progress been in targeting kidney diseases due to poor gene delivery efficiency renal cells. The development novel therapy vectors medical intervention treat is needed. In this study, we designed and produced a pseudotyped lentiviral vector with envelope glycoproteins Zika virus (ZIKV), evaluated its potential use viral entry, neutralization...
Aging | doi:10.18632/aging.100806. Zachary A. Kopp, Jo-Lin Hsieh, Andrew Li, William Wang, Dhelni T. Bhatt, Angela Lee, Sae Yeon Kim, David Fan, Veevek Shah, Emaad Siddiqui, Radhika Ragam, Kristen Park, Dev Ardeshna, Kunwoo Rachel Wu, Hardik Parikh, Ayush Yuh-Ru Lin, Yongkyu Park
The renin-angiotensin system (RAS) plays important roles in tumorigenesis and is involved with several hallmarks of cancer.Evidence shows that angiotensin II (AngII) type 1 receptor (AT1R) blockers may be associated improved outcome prostate cancer patients.Furthermore, our previous studies indicate increased expression Ang 2 (AT2R) alone induced apoptosis human lines, an effect did not require II.This study aimed to investigate the effects AT2R on tumor growth vivo we hypothesized...
Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated lupus erythematosus (SLE), which is disproportionately prevalent Asians. This multicentre, cross-sectional study aims to the prevalence of among SLE using these guidelines, and identify independent predictors develop a prediction model patients. from participating centres will undergo an echocardiography- biomarker-based procedure as DETECT study. Standard right heart...
SUMMARY Extra‐abdominal fibromatosis of the breast is rare with clinical and radiological features closely resembled malignant tumour. We describe, in a 40‐year‐old Chinese male patient palpable left mass, clinical, pathological this benign though locally aggressive
Lin, Lu MD; Kwan, Chi Ting MBBS; Yap, Pui Min Fung, Sau Yung Tang, Hok Shing Tse, Wan Wai Vivian Cheuk Nam Felix Chow, Yin Hay Phoebe Yiu, Nga Ching Lee, Pok Fong, Ambrose Ho Tung BSc; Ren, Qing-Wen Wu, Mei-Zhen Ka Chun Kevin MBBS, MRCP; Leung, Yu Li, Andrew Montero, David PhD; Vardhanabhuti, Varut Hai, JoJo Siu, Chung-Wah HungFat Pennell, Dudley John MRCP, MSCMR; Mohiaddin, Raad Senior, Roxy Kai-Hang Ng, Ming-Yen BMBS Author Information
Background Myocardial scar and edema can be assessed by late gadolinium enhancement (LGE) T2W cardiac magnetic resonance (CMR) respectively, but each has important limitations. T1-mapping emerged as an alternative method to characterize acute ischemic injury contemporary mapping sequences make this clinically feasible. We the T1 relaxation time in myocardial segments exhibiting varying degrees of patients after MI. Methods T2W, (using Shortened Modified LookLooker Inversion recovery...
Background Diastolic function is almost exclusively assessed using transthoracic echocardiography (TTE), however velocityencoded phase-contrast imaging permits diastolic evaluation with cardiac magnetic resonance (CMR). However, previous studies have utilized heterogeneous planimetric contour locations to measure mitral valve (MV) inflow velocities and the optimal uncertain. We therefore evaluated CMR MV measured at various regions against TTE identify method.
The main psychoactive compound within the cannabis plant, Δ9-tetrahydrocannabinol (THC), is thought to drive both sensation of "high" and cognitive impairments associated with consumption. Researchers keen understand how impairs cognition have, therefore, studied behavioral effects systemic injections THC in animal models. However, contains multiple other cannabinoids which may critically modulate resulting effects. Users also typically eat or smoke cannabis, leading concern over...
Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): United Christian Hospital Ruttonjee and Tang Siu Kin Hospitals Background Better risk stratification in pulmonary hypertension (PH) by echocardiography (echo) to detect ventricular vascular uncoupling may act as gate-keeper for downstream management, such MRI expensive therapies. Studies showed modest correlation found between RV peak global longitudinal strain (RVGLS), which is afterload...
A multisection, two‐dimensional, Fourier transform, doublegradient‐ echo magnetic resonance imaging sequence with partial flip‐angle excitation and section doubling by radiofrequency encoding approximately doubles the signal‐to‐noise ratio obtainable from a conventional spin‐echo at low field strength, while maintaining essentially equivalent contrast.