A5080867448- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Wound Healing and Treatments
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Mechanical Circulatory Support Devices
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- Cancer Genomics and Diagnostics
Baylor College of Medicine
2005-2022
Texas Children's Hospital
2022
Blood transfusion is frequently needed to maintain adequate haemostasis and improve oxygenation for patients treated with extracorporeal membrane (ECMO). It more so neonates immature coagulation systems who require surgical intervention such as congenital diaphragmatic hernia (CDH) repair. There growing evidence suggesting an association between blood transfusions increased mortality. The aim of this study evaluate the during peri-operative period CDH repair, among other clinical parameters,...
Abstract Introduction: Hepatoblastoma (HB) is the most frequent liver malignancy of childhood with an annual incidence 1.5 per million and a survival rate less than 50%. Due to significant side effects ineffectiveness standard chemotherapy for relapse refractory disease, treatment options are now shifting towards targeted therapies. Cyclin-dependent kinases (CDKs) potential cancer therapeutic targets because their critical role in promoting cell growth regulating transcriptional processes....
Abstract Genomic instability is a hallmark of most cancers and presumably results from dysfunction mutator genes. Yet methods to identify the complete catalogue genes in human systematic investigations their roles cancer are lacking. Here we developed MutaGene define associated with suppression genomic identified 1534 putative based on TCGA dataset. We observed that patients deficiency genes, contrast other pathways or DNA repair pathways, were coupled strong immunogenicity, e.g., elevated...