A5044210009- Genetic diversity and population structure
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Amphibian and Reptile Biology
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Wildlife Ecology and Conservation
- RNA modifications and cancer
- Heat shock proteins research
- Cancer Mechanisms and Therapy
- Identification and Quantification in Food
- Animal Behavior and Reproduction
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Microbial Inactivation Methods
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- ATP Synthase and ATPases Research
- NF-κB Signaling Pathways
- Pluripotent Stem Cells Research
China National Nuclear Corporation
2024-2025
Kyoto University
2024
Sichuan University
2012-2023
Hubei University of Medicine
2016
Hebei North University
2016
UPMC Hillman Cancer Center
2009-2015
University of Pittsburgh
2014
In-Q-Tel
2010
Union University
1997
Hsin Sheng College of Medical Care and Management
1996
Abstract microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported cancer. To gain insights into its potential role tumorigenesis, we generated knockout colon cancer cells through targeting. Unbiased microarray analysis combined with bioinformatics identified cell cycle regulator Cdc25A as a target. suppressed defined sequence 3′-untranslated region. We found is induced...
Abstract The Bcl-2 family protein Mcl-1 is often degraded in cancer cells subjected to effective therapeutic treatment, and defective degradation has been associated with intrinsic acquired drug resistance. However, a causal relationship between anticancer responses not directly established, especially solid tumor where inhibition alone insufficient trigger cell death. In this study, we present evidence that participates determining colon cells. setting, was induced by variety of multikinase...
Inflammatory activation and intestinal flora imbalance play an essential role in the development progression of colorectal cancer (CRC). Berberine (BBR) has attracted great attention recent years due to its heath-related benefits inflammatory disorders tumors, but intricate mechanisms have not been fully elucidated. In this study, effects mechanism BBR on colon were investigated azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model. Our results...
Abstract Heat shock protein 90 (Hsp90) is widely overexpressed in cancer cells and necessary for maintenance of malignant phenotypes. Hsp90 inhibition induces tumor cell death through degradation its client oncoproteins has shown promises preclinical studies. However, the mechanism by which inhibitors kill not well-understood. Biomarkers associated with differential sensitivity resistance to remain be identified. In this study, we found that colorectal containing inactivating mutations FBW7,...
Abstract Caspase-3 is the best known executioner caspase in apoptosis. We generated caspase-3 knockout (C3KO) and knockdown human colorectal cancer cells, found that they are unexpectedly sensitized to DNA-damaging agents including 5-fluorouracil (5-FU), etoposide, camptothecin. C3KO xenograft tumors also displayed enhanced therapeutic response cell death 5-FU. cells showed intact apoptosis activation of caspase-7 -9, impaired processing caspase-8, induction necrosis agents. This form...
A new and efficient low-temperature chlorination-roasting–acid-leaching uranium process was proposed to solve the problems of low leaching efficiency, since residue does not meet discharge standard in traditional nitric acid leaching-uranium tailings process, compared with conventional chlorination roasting. XRD, SEM, particle size analysis, other analytical methods were used characterize analyze phase transformation structural changes roasting uranium-containing tailings. An investigation...
Cancer is one of the most lethal diseases worldwide, and metastasis common cause patients' deaths. Identification inhibition markers involved in process cancer cells are promising works to block improve prognoses patients. Chemokines a superfamily small, chemotactic cytokines, whose functions based on interaction with corresponding receptors. It has been found that chemokines regulate migration invasion abilities lymphocytes, as well cells. Chemokine receptor 9 (CCR9) regulates trafficking...
Ubiquitination-directed protein degradation is important in many cancers for tumor initiation and maintenance, E3 ligases containing HECT domains are emerging as new therapeutic targets. In contrast to other ligases, the role of HUWE1 ovarian cancer where dysregulated has been unclear. Here we report that genetic deletion Huwe1 mouse inhibits transformation ovary surface epithelium cells without significantly affecting cell survival apoptosis, after tumors have initiated growth....
Mutations in the Ras/Raf/MEK/ERK pathway are detected 50% of colorectal cancer cases and play a crucial role development progression. Cobimetinib is MEK inhibitor approved for treatment advanced melanoma inhibits cell viability other types cells.HCT116 cells were treated with cobimetinib, MTT assay, colony formation flow cytometry used to evaluate viability, cycle, apoptosis, respectively. The expression genes associated cycle apoptosis evaluated by quantitative real-time PCR western...
p53 plays a key role in regulating DNA damage response by suppressing cell cycle progression or inducing apoptosis depending on extent of damage. However, it is not clear why mild genotoxic stress favors growth arrest, whereas excessive lesions signal cells to die. Here we showed that TAp73, homologue thought have similar function as p53, restrains the transcriptional activity and prevents activation its downstream targets upon low levels damage, which results arrest. Extensive triggers...
Significance Colorectal cancer is the third leading cause of cancer-related death in United States, but treatment options for this disease are limited effectiveness. Most human colorectal tumors begin with an inactivating mutation adenomatous polyposis coli ( APC ) gene. We demonstrate a mechanism by which nonsteroidal antiinflammatory drugs (NSAIDs) protect against colon development killing intestinal stem cells that have lost functional APC. NSAID combines loss-induced gene expression...
This study reported the isolation and characterization of eight polymorphic microsatellite loci in endangered forest musk deer Moschus berezovskii. An improved enrichment protocol was used to isolate microsatellites, polymorphism explored with samples from wild population collected Miyalo Sichuan Province China. Approximately 70% clones genomic library constructed current contained dinucleotide (AC) repeats. Eight amplified were highly within population. The number alleles per locus ranged 6...
Forest musk deer (Moschus berezovskii) were once distributed widely in China. However, wild populations have declined dramatically because of poaching and habitat loss. Captive breeding been established for several decades, but the genetic backgrounds most captive unclear population sizes increased very slowly. To provide useful information conservation management this species, we investigated diversity structure forest by analysing a 582-bp fragment mitochondrial DNA (mtDNA) control region...