A5074461835- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- RNA regulation and disease
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- Single-cell and spatial transcriptomics
- Galectins and Cancer Biology
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CRISPR and Genetic Engineering
- Poxvirus research and outbreaks
- Cancer-related Molecular Pathways
- Gut microbiota and health
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- FOXO transcription factor regulation
Guangxi Medical University
2021-2025
Guangxi Zhuang Autonomous Region Department of Education
2023-2024
Sun Yat-sen University
2019-2023
Guangdong Provincial People's Hospital
2020-2021
Zhongshan Hospital
2021
Kunming Institute of Zoology
2016-2019
Chinese Academy of Sciences
2017-2019
University of Chinese Academy of Sciences
2016-2017
Background The May 2022 global outbreak of monkeypox (MPX) poses a threat to the health men who have sex with men. However, there is limited data on willingness MSM receive vaccination in Southern China. This study aimed assess knowledge MPX, concerns regarding and vaccination, as well their correlates, among Methods We conducted Web-based online survey China from August September 2022. Data were collected socio-demographic characteristics, knowledge, worries, MPX vaccination. Multivariate...
Abstract As the most abundant messenger RNA (mRNA) modification, N6-methyladenosine (m6A) plays a crucial role in fate, impacting cellular and physiological processes various tumor types. However, our understanding of m6A methylome heterogeneity remains limited. Herein, we collected analyzed methylomes across nine human tissues from 97 sequencing (m6A-seq) (RNA-seq) samples. Our findings demonstrate that exhibits different compared to normal tissues, which contributes diverse clinical...
Abstract N6-methyladenosine (m6A) is a reversible and dynamic RNA modification in eukaryotes. However, how cells establish cell-specific m6A methylomes still poorly understood. Here, we developed computational framework to systematically identify trans regulators of through integrating gene expressions, binding targets motifs large number proteins (RBPs) with co-methylation network constructed using large-scale across diverse cell states. We applied the successfully identified 32...
The monkeypox outbreak has become a global public health emergency. lack of valid and safe medicine is crucial obstacle hindering the extermination orthopoxvirus infections. identification potential inhibitors from natural products, including Traditional Chinese Medicine (TCM), by molecular modeling could expand arsenal antiviral chemotherapeutic agents. Monkeypox DNA topoisomerase I (TOP1) highly conserved viral repair enzyme with small size low homology to human proteins. protein model...
The coronavirus disease 2019 (COVID-19) pandemic has caused many deaths worldwide. To date, the mechanism of viral immune escape remains unclear, which is a great obstacle to developing effective clinical treatment. RNA processing mechanisms, including alternative polyadenylation (APA) and splicing (AS), are crucial in regulation most human genes types infectious diseases. Because role APA AS response severe acute respiratory syndrome 2 (SARS-CoV-2) infection unknown, we performed de novo...
The outbreak of coronavirus disease 2019 (COVID-19) has affected more than 200 countries and regions to date. mRNA m 6 A methylation been reported as a new therapeutic target in COVID-19 patients, received widespread attention. However, the effects on clinical features well molecular characterization real patients are largely unclear. We collected RNA-seq data from 100 sequenced A-seq peripheral blood mononuclear cells (PBMCs) two patients. Using bioinformatics analysis, we found that is...
Ubiquitination-directed protein degradation is important in many cancers for tumor initiation and maintenance, E3 ligases containing HECT domains are emerging as new therapeutic targets. In contrast to other ligases, the role of HUWE1 ovarian cancer where dysregulated has been unclear. Here we report that genetic deletion Huwe1 mouse inhibits transformation ovary surface epithelium cells without significantly affecting cell survival apoptosis, after tumors have initiated growth....
Abstract Serine/arginine-rich splicing factor 7 (SRSF7), a known factor, has been revealed to play oncogenic roles in multiple cancers. However, the mechanisms underlying its have not well addressed. Here, based on N 6-methyladenosine (m 6 A) co-methylation network analysis across diverse cell lines, we find that gene expression of SRSF7 is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. We then indicate novel regulator, which specifically facilitates methylation...
Abstract Talaromyces marneffei (TM) immune evasion is an important factor leading to the high mortality rate of Penicilliosis marneffei. N 6 ‐methyladenosine (m A) plays roles in host response various pathogen infections, yet its role TM and HIV/TM coinfection remains largely unexplored. Here we reported genome‐wide transcriptional m A profiles mono‐infection coinfection. Our finding revealed dynamic alterations global levels upregulation reader YTH RNA binding protein C2 (YTHDC2)...
Breast cancer is the most commonly diagnosed malignancy in women. Several key genes and pathways have been proven to correlate with breast pathology. This study sought explore differences transcription factors (TFs), transcriptional regulation networks dysregulated different tissues cancer. We employed 14 datasets from NCBI-GEO performed an integrated analysis three including breast, blood saliva. The results showed that there were eight (CEBPD, EGR1, EGR2, EGR3, FOS, FOSB, ID1 NFIL3)...
Abstract As acute infectious pneumonia, the coronavirus disease-2019 (COVID-19) has created unique challenges for each nation and region. Both India United States (US) have experienced a second outbreak, resulting in severe disease burden. The study aimed to develop optimal models predict daily new cases, order help public health strategies. autoregressive integrated moving average (ARIMA) models, generalised regression neural network (GRNN) ARIMA–GRNN hybrid model exponential smoothing (ES)...
Competitive endogenous RNA (ceRNA) reveals new mechanisms for interactions between RNAs, which have been considered to play a significant role in pathogen-host innate immune response. However, knowledge of ceRNA regulatory networks Talaromyces marneffei (TM)-macrophages is still limited. Next-generation sequencing technology (NGS) was used obtain mRNA, miRNA and lncRNA expression profiles TM-infected macrophages. The R package DESeq2 identify differentially expressed lncRNA, mRNA. GOseq Gene...
Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer in world, with a high degree of malignancy and recurrence. The influence ceRNA network tumor on biological function very important, It has been reported that many lncRNA play key role development. In our study, integrated data analysis revealed potential eight novel biomarkers hepatocellular carcinoma. Methods Transcriptome clinical were downloaded from Cancer Genome Atlas (TCGA) portal. Weighted gene...
Interleukin (IL) 15 is one of the main cytokines controlling cytotoxic lymphocyte survival and growth. Despite its receptor functional similarity to IL-2, IL-15 affects a wider target cell population utilizes different mechanisms in activation. The role lymphokine-activated killer (LAK) generation vitro potential cytotoxicity compared with equivalent low concentration IL-2 or without mitogens (phytohemoglutinin (PHA) anti-CD3 antibody) have been investigated this study. treatment resulted...
ABSTRACT Pancreatic cancer is one of the most lethal common cancers. The cell origin pancreatic ductal adenocarcinoma (PDAC) has been controversial, and recent evidence suggested acinar cells as probable candidate. However, genetic alterations driving transformation in fully mature animals remain to be deciphered. In this study, lentivirus was used a tool introduce engineering tree shrew explore driver mutation essential for malignant transformation, establishing novel PDAC model, because we...
Abstract The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. dataset GSE157103 was used to perform weighted gene co-expression network analysis on 100 COVID-19 patients in our analysis. Through analysis, we identified a key module which significantly related This age-related could predict Intensive Care Unit status and mechanical-ventilation usage, enriched positive regulation T...
Although apatinib is a promising drug for the treatment of liver cancer, underlying resistance mechanism still unclear. Here, we constructed apatinib-resistant HepG2 cells. We then characterized epigenomic, transcriptomic, and proteomic landscapes both in non-resistant Differential expression, ATAC-seq, data analyses were performed. found that cell cycle related protein RB1 may play an essential role process resistant to hepatocarcinoma. Moreover, there extensive variations at transcriptome,...
Talaromyces marneffei (T. marneffei) immune escape is essential in the pathogenesis of talaromycosis. It currently known that T. achieves through various strategies. However, role cellular alternative splicing (AS) remains unclear. Here, we depict AS landscape macrophages upon infection via high-throughput RNA sequencing and detect a truncated protein NCOR2 / SMRT, named NCOR2-013, which significantly upregulated after infection. Mechanistic analysis indicates NCOR2-013 forms co-repression...
Gut Universe Database (GutUDB) provides a comprehensive, systematic, and practical platform for researchers, is dedicated to the management, analysis, visualization of knowledge related intestinal diseases. Based on this database, eight major categories omics data analyses are carried out explore genotype-phenotype characteristics certain disease. The first tool comprehensive research diseases will help each researcher better understand intestine serves as central organ in digestive system...
As a key process in transcriptional regulatory mechanisms, alternative splicing (AS) plays crucial role maintaining the diversity of RNA and protein expression, mediates immune response infectious diseases, especially for COVID-19. Therefore, urgent data gathering more research AS profiles microbe-infected human cells are needed to improve understanding COVID-19 related diseases. Herein, we have created CASA, Alternative Splicing Atlas provide convenient computing platform studies...