A5000701402- Parasitic Infections and Diagnostics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Gut microbiota and health
- Plant and Fungal Interactions Research
- Dysphagia Assessment and Management
- Insect and Pesticide Research
- Advanced Glycation End Products research
- Microbial infections and disease research
- Mycobacterium research and diagnosis
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Food Security and Health in Diverse Populations
- Lipid metabolism and disorders
- RNA modifications and cancer
- Silkworms and Sericulture Research
- Contact Dermatitis and Allergies
- Apelin-related biomedical research
- Dialysis and Renal Disease Management
- PI3K/AKT/mTOR signaling in cancer
- Enterobacteriaceae and Cronobacter Research
- Inflammasome and immune disorders
- Study of Mite Species
Chongqing Medical University
2014-2025
Southwest University
2007-2013
State Key Laboratory of Silkworm Genomic Biology
2013
Microsporidian Nosema bombycis has received much attention because the pébrine disease of domesticated silkworms results in great economic losses silkworm industry. So far, no effective treatment could be found for pébrine. Compared to other known parasites, N. can unusually parasitize a broad range hosts. To gain some insights into underlying genetic mechanism pathological ability and host expansion this parasite, comparative genomic approach is conducted. The genome two antheraeae (an...
Abstract Long intergenic noncoding RNAs (lincRNAs) have been gradually identified to be functional in a variety of different mechanisms associating with development and epigenetic regulation cellular homeostasis. However, the study lincRNAs diabetic nephropathy (DN) is still its infancy. Here, we found dysexpressed long (lncRNAs) renal tissues db/db DN mice compared db/m by RNA sequencing. In this study, 5 were confirmed express consistent trend among these DN-related lncRNAs both vivo...
Diabetic nephropathy (DN) is one of the most common complications diabetes mellitus (DM). However, exact mechanism not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when treated with NAR 50 mg/d for 6 weeks. Mesangial cell (MMCs) proliferation inhibited group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), cycle analysis...
Introduction Inflammatory cell infiltration is a novel hallmark of diabetic kidney disease (DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial communication may play an important role renal fibrosis. Circular RNAs (circRNAs) have been reported the pathogenesis various human diseases involving macrophages activation, including DKD. However, exact mechanism circRNAs macrophage and fibrosis DKD remains obscure. Methods In our study, circRNA circUBXN7 was identified...
To investigate the mechanism of microbe-gut-brain axis interactions in Parkinson's disease (PD), mice were treated with Lactobacillus acidophilus (LA) after intraperitoneal injection 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to establish a model PD. In this study, we examined for changes motor activity, striatal tyrosine hydroxylase (TH), brain synaptophysin (SNY), glial cells, inflammatory factors and tight junctions, as well colonic GLP-1, FFAR2/FFAR3 GLP-1 receptor levels, 16S...
Evidence has shown that long noncoding RNAs (IncRNAs) in the competing endogenous RNA (ceRNA) network are involved various diseases. However, there is a lack of studies ceRNA diabetic nephropathy (DN). In this study, we investigated effect IncRNAs on mesangial cell (MC) proliferation DN-related networks. Differences IncRNA and mRNA expression between DN normal mouse kidney tissues were detected with RNA-seq, IncRNA/mRNA/microRNA (miRNA) networks constructed by R3.4.3. Computational analysis...
Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common complication diabetes. However, initiating molecular events triggering DN are unknown. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in DN.The expression level lncRNA 1500026H17Rik (150Rik for short) was measured by qRT-PCR (quantitative real-time PCR). Cell proliferation ability detected 5-Ethynyl-2'-deoxyuridine (EdU). The relationship between 150Rik and microRNA 451...
Whole-transcriptome analysis using RNA sequencing (RNA-seq) affords broader insights about gene expression regulatory networks in diabetic nephropathy (DN). To better explore the molecular basis of DN, kidney tissue from db/db DN model mice and control were submitted to RNA-seq analysis. Thousands long noncoding RNAs (lncRNAs) messenger (mRNAs) found be significantly differentially expressed group relative group. research mechanism these lncRNAs mRNAs, integrated co-expression constructed...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. Long non-coding RNAs (lncRNAs) are regulators in DN progression. However, the regulatory mechanisms multiple lncRNAs remain to be determined. Our aim was investigate function and molecular mechanism lncRNA RNA component mitochondrial RNAase P (Rmrp) DN. Here, we observed that expression Rmrp up-regulated kidney db/db mice high glucose induced glomerular mesangial cells (MC). More importantly, abnormal transcription by...
Copper nanowires (Cu NWs) were modified with graphene oxide (GO) nanosheets to obtain a sensor for simultaneous voltammetric determination of ascorbic acid (AA), dopamine (DA) and acetaminophen (AC). The nanocomposite was obtained via sonication, its structures characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) energy-dispersive spectroscopy (EDS). electrochemical oxidation activity the materials (placed on glassy carbon electrode) studied cyclic voltammetry...
Enterocytozoon bieneusi can cause severe diarrhea in children and adults. However, China, there are scant studies on E. diarrheal adults, with the exception of prevalence genotyping data a small number cities including Hubei, Shanghai, Heilongjiang. In this study, 196 fecal samples (n = 132 Chongqing, n 44 Shandong, 20 Hubei) were collected, 91 from 105 Through microscopic examination, 19 positive (11 8 adults) detected. Using PCR internal transcriptional spacer (ITS) region was utilized by...
Abstract Diabetic nephropathy (DN)—a common complication of diabetes—is the primary cause end-stage renal disease. Sodium butyrate (NaB) is a short-chain fatty acid (SCFA) that metabolic product intestinal bacterium, and its protective effect on kidney has been reported in cases DN. However, underlying mechanism remains unclear. The aim present study was to investigate NaB globe transcriptome changes In our study, 8-week-old male db/db mice suffering from DN were randomly divided into two...
Among approximately 14 human-pathogenic microsporidian species, Enterocytozoon bieneusi is the most common. It can inhabit small intestines, causing chronic diarrhea and wasting syndrome. Prevalence genotype data for E. in humans available only a few provinces of China. In current study, 93 fecal specimens were collected from diarrheic children Chongqing. Polymerase chain reaction amplification sequencing internal transcribed spacer ( ITS) region rDNA sequence identified 11 (11.83%) positive...