Chicken growth traits are important economic in broilers. A large number of studies available on finding genetic factors affecting chicken growth. However, most these identified chromosome regions containing putative quantitative trait loci and causal mutations is still a challenge. In this genome-wide association study (GWAS), we narrow 1.5 Mb region (173.5–175 Mb) (Gallus gallus) (GGA) 1 to be strongly associated with using 47,678 SNPs 489 F2 chickens. The included aggregate body weight...

Background Despite establishing an association between gut microbiota and spondyloarthritis (SpA) subtypes, the causal relationship them remains unclear. Methods Gut data were obtained from MiBioGen collaboration, SpA genome-wide study (GWAS) summary FinnGen collaboration. We conducted a two-sample Mendelian randomization (MR) analysis using inverse-variance-weighted method supplemented with four additional MR methods (MR-Egger, weighted median, simple mode, mode). Pleiotropy heterogeneity...

Abstract With annually increased coal mining depth, gas extraction becomes more and problematic. The effect depends on seam permeability, which, in turn, is affected by many factors, including loading unloading stresses strains the seam. Stresses induce internal cracks, resulting cleats emission channels, permeability permanently changes accordingly. To clarify stress-induced effects this survey summarized available approaches used to link stress path seepage law body law, which can be...

In this work, a simplified wetting boundary scheme in the phase-field lattice Boltzmann model is developed for phenomena on curved boundaries. The proposed combines advantages of fluid-solid interaction and geometric scheme---easy to implement (no need interpolate values parameters exactly solid boundaries find proper characteristic vectors), value contact angle can be directly prescribed, no unphysical spurious mass layer---and avoids leakage. Different from previous works, order parameter...

In this paper, an improved thermal multiple-relaxation-time (MRT) lattice Boltzmann (LB) model is proposed for simulating liquid-vapor phase change. A temperature equation first derived change, where the latent heat of vaporization decoupled with state. Therefore, can be arbitrarily specified in practice, which significantly improves flexibility present LB The Laplacian term avoided and gradient calculated through a local scheme. To solve accurately efficiently, MRT nondiagonal relaxation...

In this work, a lattice Boltzmann (LB) model based on the phase-field method is proposed for simulating large density ratio two-phase flows. An improved multiple-relaxation-time (MRT) LB equation first developed to solve conserved Allen-Cahn (AC) equation. By utilizing nondiagonal relaxation matrix and modifying equilibrium distribution function discrete source term, AC can be correctly recovered by MRT with no deviation term. Therefore, calculations of temporal derivative term in previous...

Different electrolytes are used to fabricate nickel structures in MEMS devices by the LIGA or UV-LIGA process meet different requirements. In order investigate microstructure and mechanical properties of thin films electroplated electrolytes, four sets specimens were fabricated electrolytes: sulfamate bath with both saccharine butynediol added (type A-I); A-II); watts B); chloride C). The function these additives was obtain stress-free films. measured our uniaxial tensile test system; their...

Primary pulmonary neoplasms rarely occur in children, but the majority of those that do are malignant. Mucoepidermoid carcinoma (MEC) represents ~10% all primary malignant tumors. However, MEC is not usually considered clinical differential diagnosis pediatric practice. The present study presents case a seven-year-old female with one-year history recurrent hemoptysis. Computerized tomography (CT) scans revealed tumor originating right lower lobe bronchus. patient did receive any radiation...

In this work, our recently developed weighted-orthogonal multiple-relaxation-time pseudopotential lattice Boltzmann (PLB) model [J. Tang et al., “Multiphase flow simulation with three-dimensional model,” Phys. Fluids 33, 123305 (2021)] is further extended to simulate the complex wetting phenomenon on curved surfaces at large density ratios (ρl/ρg∼1000), where a new geometrical formulation scheme proposed characterize wettability of boundary. Compared existing schemes, significant advantage...

Psoriasis is a common chronic, recurrent, and inflammatory skin disease. Identifying novel potential biomarkers valuable in the treatment diagnosis of psoriasis. The goal this study was to identify key psoriasis analyze underlying mechanisms.Psoriasis-related datasets were downloaded from Gene Expression Omnibus database screen differential genes datasets. Functional pathway enrichment analyses performed on differentially expressed (DEGs). Candidate for identified GSE30999 GSE6710 using four...

The support spring of a uniaxial micro-tensile system for testing micro-scale thin films is studied in this paper. Stresses different shape springs are analyzed with the finite element method (FEM). simulated results show that stress an S-shaped lower compared U-shaped same dimensions (100 µm thick, 100 wide, 250 inner diameter and 5 turns). maximum about 133 MPa when displacement imposed at one end along lateral side. number turns has most important effect on stiffness spring. Moreover,...

Abstract Background Circular RNAs are involved in autoimmune disease pathogenesis. Our previous study indicated that circPTPN22 is diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, but the underlying mechanisms remain unclear. Methods First, expression of was detected by real-time PCR western blotting. After overexpression or knockdown circPTPN22, proliferation Jurkat cells CCK-8 assay, apoptosis flow cytometry. In addition, relationship between...

In this paper, based on two lattice models (D3Q19 and D3Q27), three-dimensional weighted-orthogonal multiple-relaxation-time pseudopotential Boltzmann (WMRT-PLB) with tunable thermodynamic consistency surface tension are developed in which the high-order terms of equilibrium density distribution function discrete forcing term moment space eliminated, thus, implementation collision process is simplified. The Chapman–Enskog analysis shows that WMRT-PLB can correctly recover macroscopic...

Among approximately 14 human-pathogenic microsporidian species, Enterocytozoon bieneusi is the most common. It can inhabit small intestines, causing chronic diarrhea and wasting syndrome. Prevalence genotype data for E. in humans available only a few provinces of China. In current study, 93 fecal specimens were collected from diarrheic children Chongqing. Polymerase chain reaction amplification sequencing internal transcribed spacer ( ITS) region rDNA sequence identified 11 (11.83%) positive...

This paper presents a novel design and fabrication of test chips with nickel free-standing specimen for the micro uniaxial tensile test. To fabricate on quartz substrate significantly reduces time, minimizes number steps eliminates effect wet anisotropic etching process mechanical properties. The chip can be gripped tightly to machine aligned accurately in pulling direction; furthermore, approximately straight rather than traditional dog-bone structure enables strain directly measured by...

Objective of this study is to analyze the range necrosis after using different freezing times and freeze-thaw cycles during percutaneous cryosurgery, in order create a suggestion for optimizing technique lung cryoablation. Six healthy pigs were given CT scan histological investigation cryosurgery on both lungs. Three cryoprobes inserted into left right lungs each pig, respectively. Cryoablation was performed with two an active 10-minute argon lung, freeze followed by 5-minute thaw helium. In...

In view of the separation form separator from back carrier upward and side outward, separation-safety research is carried out by taking a cluster munition as an example. previous wind tunnel free-flight tests, similarity law vertical, downward, moving submunition was used to design submunitions at different positions in initial-velocity directions, which resulted large discrepancies between test results real flight. test, each has independent time-reduction ratio with respect dispenser. Even...

Pure bronchial sleeve resection and reconstruction is a type of rare thoracic surgery, especially for the second carina on left side, needs more exquisite surgical techniques, patient selection to such surgery often requires rigorous screening. We present two cases main adenoid cystic carcinoma with reconstruction. The purpose this paper recommend useful supplement conventional some very selected patients.