A5029115295- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Agronomic Practices and Intercropping Systems
- Crop Yield and Soil Fertility
- Machine Learning in Materials Science
- Medicinal Plant Pharmacodynamics Research
- Soil Carbon and Nitrogen Dynamics
- Ovarian cancer diagnosis and treatment
- Calpain Protease Function and Regulation
- Catalysis and Oxidation Reactions
- Traditional Chinese Medicine Studies
- Glioma Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Retinal and Optic Conditions
- Cytokine Signaling Pathways and Interactions
- Microbial infections and disease research
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Glaucoma and retinal disorders
- Brain Tumor Detection and Classification
- S100 Proteins and Annexins
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
Second Affiliated Hospital of Zhejiang University
2016-2024
Anhui Provincial Hospital
2023
University of Science and Technology of China
2023
Lishui City People's Hospital
2011-2022
Wenzhou Medical University
2021-2022
Background It remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes a cohort RAS/BRAF wild-type colorectal cancer (CRC) patients initially unresectable liver metastases (CRLM). To that end, we sought to comparatively evaluate efficacy and safety cetuximab plus FOLFOXIRI (triplet arm) versus FOLFOX (doublet as conversion regimen (i.e., resectable) CRC CRLM. Methods findings This open-label, randomized trial was...
Pretreatment systemic inflammatory response has been confirmed to have prognostic value in patients with inoperable non-small-cell lung cancer (NSCLC). Increasing studies show that the modified Glasgow score (mGPS), a based on C-reactive protein (CRP) and albumin, is factor these patients. This study was aimed at recognizing possible factors new scores of NSCLC pretreatment response.We retrospectively reviewed clinicopathological data 105 who received first-line chemotherapy as initial...
Psoriasis is a common chronic, recurrent, and inflammatory skin disease. Identifying novel potential biomarkers valuable in the treatment diagnosis of psoriasis. The goal this study was to identify key psoriasis analyze underlying mechanisms.Psoriasis-related datasets were downloaded from Gene Expression Omnibus database screen differential genes datasets. Functional pathway enrichment analyses performed on differentially expressed (DEGs). Candidate for identified GSE30999 GSE6710 using four...
Glioblastoma multiforme (GBM) is the most malignant and multiple tumors of central nervous system. The survival rate for GBM patients less than 15 months. We aimed to uncover potential mechanism in tumor microenvironment provide several candidate biomarkers prognosis. In this study, ESTIMATE analysis was used divide into high low immune or stromal score groups. Microenvironment associated genes were filtered through differential analysis. Weighted gene co-expression network (WGCNA) performed...
<title>Abstract</title> Colorectal cancer (CRC) is the most common digestive tumor, and patients with advanced CRC have a very poor prognosis. Anoikis form of apoptosis induced by loss cell attachment or interruption adhesion-dependent signaling pathways tumor cells can become resistant to anoikis when detached from stroma. resistance (AR) prerequisite for an important indicator metastatic potential cells. While AR epithelial mesenchymal transition (EMT) play roles in progression CRC, joint...
The study focused on the therapeutic effects of resveratrol, sirtuin 1 (Sirt1) activator, glaucoma, and its influence mitogen-activated protein kinase (MAPK) pathway. Specifically, C57BL/6 mice were used glaucoma mouse model was established by intraperitoneal injection N-methyl-D-aspartate (NMDA). According to different treatment methods, they randomly rolled into 3 groups: control group (no treatment), (glaucoma model), resveratrol (Res) (intraperitoneal 20 mg/kg solution basis group)....
摘要： 【摘要】 在新型冠状病毒（简称新冠病毒）感染大流行期间银屑病的管理引起了广泛关注，越来越多的研究者从不同角度探究银屑病与新冠病毒感染之间的关系。本文回顾银屑病患者使用生物制剂对新冠病毒感染的影响，以及银屑病与新冠病毒感染之间的相互作用，旨在为皮肤科医生和银屑病患者提供更为可靠的诊疗指导，为后续研究提供一定的参考依据。
Objective To investigate the expression and clinical effect of myeloid-derived suppressor cells(MDSCs)in peripheral blood patients with multiple myeloma(MM). Methods From October 2015 to June 2017, 40 newly treated MM in Hematology Department Lishui people′s hospital were selected as group, 27 males 13 females, aged(58±8)years ranging from 48 76 years.In addition, healthy people control including 25 15 aged(56±11)years, 45 74 first-line treatment was used after admission.The MDSCs,...
This study was aimed to explore the application of fuzzy C-means (FCM) algorithm in MR images acquired immune deficiency syndrome (AIDS) patients. Sixty AIDS patients with central nervous disease were selected as research object. A method brain image segmentation based on FCM clustering optimization proposed, and optimized neighborhood pixel correlation gray difference. The introduced into objective function obtain more accurate membership features image. segmented can retain original...