A5100379941- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Glioma Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Photosynthetic Processes and Mechanisms
- Ion channel regulation and function
- RNA and protein synthesis mechanisms
- Aquaculture disease management and microbiota
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Blood Pressure and Hypertension Studies
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Renal and related cancers
- Mitochondrial Function and Pathology
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
Huazhong Agricultural University
2009-2025
Jiangnan University
2018-2025
Nanjing Medical University
2023-2025
Beijing Chao-Yang Hospital
2022-2025
Tianjin Medical University
2022-2025
First Affiliated Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2022-2024
University of Florida
2015-2024
Wannan Medical College
2022-2024
Guangzhou University of Chinese Medicine
2022-2024
The earliest step in creating the cerebral cortex is specification of neuroepithelium to a cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as classic selector gene essential intrinsic determinant identity. activity restricted an early critical period when stem cells comprise neuroepithelium, where it cell-autonomously specify identity suppress alternative fates spatially dependent manner. Laterally, null adopt antihem identity, whereas...
Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC) patients. How to improve therapeutic options for patients with metastatic CRC core question treatment. However, complexity and diversity stromal context tumor microenvironment (TME) liver metastases have not been fully understood, influence cells on response chemotherapy unclear. Here we performed an in-depth analysis transcriptional landscape CRC, matched blood at single-cell resolution, a systematic...
Objective Metabolic syndrome is a common condition among middle-aged and elderly people. Recent studies have reported the association between obesity- lipid-related indices metabolic syndrome, but whether those conditions could predict still inconsistent in few longitudinal studies. In our study, we aimed to by Chinese adults. Method A national cohort study that consisted of 3,640 adults (≥45 years) was conducted. total 13 indices, including body mass index (BMI), waist circumference (WC),...
To predict the optimal cut-off values for screening and predicting metabolic syndrome(MetS) in a middle-aged elderly Chinese population using 13 obesity lipid-related indicators, to identify most suitable predictors.The data this cross-sectional investigation came from China Health Retirement Longitudinal Study (CHARLS), including 9457 people aged 45-98 years old. We examined waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity (VAI), shape (ABSI),...
Abstract To investigate the screening and predicting functions of obesity- lipid-related indices for type 2 diabetes (T2D) in middle-aged elderly Chinese, as well ideal predicted cut-off value. This study's data comes from 2011 China Health Retirement Longitudinal Study (CHARLS). A cross-sectional study design was used to relationship T2D 13 indices, including body mass index (BMI), waist circumference (WC), waist–height ratio (WHtR), visceral adiposity (VAI), a shape (ABSI), roundness...
Much research has implicated the striatum in motor learning, but underlying mechanisms have not been identified. Although NMDA receptor (NMDAR)-dependent long-term potentiation observed striatum, its involvement learning remains unclear. To examine role of striatal NMDAR we created striatum-specific NMDAR1 subunit knockout mice, analyzed anatomy and neuronal morphology these evaluated their performance on well established tasks, performed electrophysiological recordings to assay function...
A specific mutation (ΔE) in torsinA underlies most cases of the dominantly inherited movement disorder, early-onset torsion dystonia (DYT1). TorsinA, a member AAA+ ATPase superfamily, is located within lumen nuclear envelope (NE) and endoplasmic reticulum (ER). We investigated an association between nesprin-3, which spans outer membrane (ONM) NE links it to vimentin via plectin fibroblasts. Mouse nesprin-3α co-immunoprecipitated with this involved C-terminal region KASH domain nesprin-3α....
DYT1 dystonia is an inherited early-onset generalized characterized by sustained muscle contractions causing abnormal, repetitive movements or postures. Most patients have a heterozygous trinucleotide GAG deletion ( ΔGAG ) in DYT1/TOR1A, coding for torsinA. Dyt1 knock-in (KI) mice global KI show motor deficits and abnormal Purkinje cell firing. However, cell-specific conditional (Pcp2-KI) improved performance, reduced sensory-evoked brain activation the striatum midbrain, functional...
We induced AKR thymomas by injecting retrovirus MCF 247 that we had tagged with a fragment of phage lambda in its U3 region. About 10-20% the 26 primary tumors studied showed both rearranged and germline c-myc bands Southern blots. The genes were cloned from two analysis others. In all four cases, rearrangement was due to integration proviruses about 2 kilobases (kb) 5' three exons opposite transcriptional orientation. Thus, viral integrations clustered within 1-kb range revealed...
TorsinA is an AAA + protein located predominantly in the lumen of endoplasmic reticulum (ER) and nuclear envelope responsible for early onset torsion dystonia (DYT1). Most cases this dominantly inherited movement disorder are caused by deletion a glutamic acid carboxyl terminal region torsinA. We used sensitive reporter, Gaussia luciferase (Gluc) to evaluate role torsinA processing proteins through ER. In primary fibroblasts from controls DYT1 patients most Gluc activity (95%) was released...
We have previously shown that mice with a CNS restricted knock-out of the integrin β1 subunit gene ( Itgb1 -CNSko mice) defects in formation lamina and folia cerebral cerebellar cortices are caused by disruption cortical marginal zones. Cortical structures postnatal adult animals also reduced size, but mechanism causes size defect has remained unclear. now demonstrate proliferation granule cell precursors (GCPs) is severely affected developing cerebellum mice. In absence expression, GCPs...
Li, Y. Q., Chen, P., Jain, V., Reilly, R. M. and Wong, C. S. Early Radiation-Induced Endothelial Cell Loss Blood–Spinal Cord Barrier Breakdown in the Rat Spinal Cord. Radiat. Res. 161, 143–152 (2004).Using a rat spinal cord model, this study was designed to characterize radiation-induced vascular endothelial cell loss its relationship early blood–brain barrier disruption central nervous system. Adult rats were given single dose of 0, 2, 8, 19.5, 22, 30 or 50 Gy cervical cord. At various...
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensory-motor neurological disorder with circadian component. RLS characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms BTBD9, along three other genes, being associated higher risk of RLS. Little about function BTBD9 its potential role...
The glutamatergic system has been implicated in the pathophysiology of depression and mechanism action antidepressants. Leptin, an adipocyte-derived hormone, antidepressant-like properties. However, functional role leptin receptor (Lepr) signaling neurons remains to be elucidated. In this study, we generated conditional knockout mice which long form Lepr was ablated selectively located forebrain structures, including hippocampus prefrontal cortex (Lepr cKO). cKO exhibit normal growth body...