A5100454975- Hernia repair and management
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Sports injuries and prevention
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pain Mechanisms and Treatments
- Sarcoma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Dendrimers and Hyperbranched Polymers
- Neuropeptides and Animal Physiology
- Soft tissue tumor case studies
- Infant Nutrition and Health
- Liver Disease Diagnosis and Treatment
- Bone Metabolism and Diseases
- Anesthesia and Sedative Agents
- Cardiovascular Disease and Adiposity
- Cytokine Signaling Pathways and Interactions
- Obesity, Physical Activity, Diet
- Pelvic and Acetabular Injuries
- Obesity and Health Practices
- Colorectal Cancer Treatments and Studies
North China University of Science and Technology
2019-2024
Second Affiliated Hospital of Jilin University
2016-2023
Abstract Cubosomes, a product of nanobioengineering, are self-structured lipid nanoparticles that act like drug-loaded theranostic probes. Here, we describe simple method for the preparation combinatorial cubosomes with, proof-of-principle, therapeutic effect against cancer cells, along with diagnostic capabilities. Anticancer drugs cisplatin and paclitaxel were loaded in combination. The coated layer poly-Ɛ-lysine, which helped avoid initial burst release drug allowed slow sustained better...
Abstract To investigate the screening and predicting functions of obesity- lipid-related indices for type 2 diabetes (T2D) in middle-aged elderly Chinese, as well ideal predicted cut-off value. This study's data comes from 2011 China Health Retirement Longitudinal Study (CHARLS). A cross-sectional study design was used to relationship T2D 13 indices, including body mass index (BMI), waist circumference (WC), waist–height ratio (WHtR), visceral adiposity (VAI), a shape (ABSI), roundness...
Abstract Exosomes contain cell-specific collections of bioactive materials including proteins, lipids, and RNAs that are transported to recipient cells exert their impacts. MicroRNAs (miRNAs) can function as tumor suppressor or oncogenic genes miR-21 is one the most frequently up-regulated miRNAs in solid tumors colon cancer. The aim this study was investigate role miR-21, secreted from exosomes, proliferation invasion cancer, along with mechanistic details. We used a variety biochemical...
Abstract c‐Myb regulates tumorigenesis in multiple cancers. Here we show, for the first time, mechanism of c‐Myb‐mediated proliferation, invasion, and drug resistance ovarian cancer (OC), most lethal gynecological cancer, a comparative analyses dietary agents, curcumin, epigallocatechin‐3‐gallate (EGCG), sulforaphane inhibiting activity. We evaluated myb expression patients with OC found its increased compared normal controls higher grade tumors, low‐grade tumors. Using ES2 OVCAR3 cell line...
Abstract Metastasis is regarded as the fatal hallmark for colon cancer, but molecular mechanisms responsible it have remained poorly defined. Glucocorticoid receptor (GR) within tumor microenvironment mediates effects of stress hormones which are used in clinics their inflammation-modulatory and immunosuppressive properties. Further, epigenetic activation GR promotes heterogeneity metastasis. Here, we sought to investigate correlation between proliferation invasion metastatic cancer...
Abstract Propofol, a common intravenous anesthetic, has been found to exert anti-cancer effects with inhibition of cancer cell proliferation, migration and invasion. We tested its possible action against HER2-overexpressing breast cells that developed resistance trastuzumab. Cell viability assay, ELISA for cytokines, mammosphere formation, quantitative RT-PCR EMT/IL-6-targeting miRNAs the in vivo experimental pulmonary metastasis model were performed understand epigenetic propofol. Propofol...
The association between adiposity parameters and cognition is complex. purpose of this study was to assess the relationship in middle-aged elderly people China.Data were obtained from a cross-sectional study. Cognitive function evaluated 5 domains, measured. analyzed using multiple linear binary logistic regression analyses.After controlling for confounders, men with overweight obesity had better scores TICS-10 ([1] total, vs normal: P = .006, β 0.04; .005, 0.04. [2] stratification by age,...
Fibromyalgia (FM) and obesity are closely related. However, little is known about how contributes to FM. Importantly, adequate evidence has shown that tumor necrosis factor alpha (TNF-α) plays a critical role in obesity. Thus, we hypothesized obesity-induced TNF-α release may potentiate FM-associated pain. To test this hypothesis, investigated the of development FM-like pain mouse model acid saline injection-induced Consistent with previous reports, showed repeated injections induced...
Objective To compare the difference in postoperative effects between standard polypropylene (SP) mesh and partial absorbable (PA) preperitoneal hernioplasty. Methods A prospective randomized controlled study was conducted to investigate 148 male patients with unilateral inguinal hernia Second Hospital of Jilin University January 2018 September 2018. They were randomly divided into two groups: SP group (73 patients) PA (75 patients). A tension-free repair using hernioplasty technique...