A5042987965- Anesthesia and Pain Management
- Nausea and vomiting management
- Pain Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Nerve injury and regeneration
- Pesticide and Herbicide Environmental Studies
- Pancreatic function and diabetes
- Reproductive Biology and Fertility
- Orthopedic Surgery and Rehabilitation
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Spine and Intervertebral Disc Pathology
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammasome and immune disorders
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
Jiangmen Polytechnic
2025
Wenzhou Medical University
2024
Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2023-2024
Peking University Shenzhen Hospital
2024
Institute of Soil Science
2023-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Shanghai Changzheng Hospital
2020-2024
Jilin Medical University
2014-2023
First People's Hospital of Chongqing
2023
Iron overload is frequently observed in type 2 diabetes mellitus (DM2), but the underlying mechanisms remain unclear. We hypothesize that hepcidin may be directly regulated by insulin and play an important role iron DM2. therefore examined hepatic content, serum parameters, intestinal absorption, liver expression rats treated with streptozotocin (STZ), which was given alone or after resistance induced a high-fat diet. The direct effect of on its molecular were furthermore determined vitro...
A hydrogel system loaded with mesenchymal stem cell-derived exosome (MSC-Exos) is an attractive new tool for tissue regeneration. However, the effect of stiffness exosome-loaded hydrogels on regeneration unclear. Here, role stiffness, during injured nerves, was assessed in vivo. The results showed that photocrosslinkable hyaluronic acid methacrylate plays important repairing nerve injury. Compared stiff exosomes, soft exosomes better repair peripheral nerves. promoted by quickly releasing to...
JOURNAL/nrgr/04.03/01300535-202408000-00034/figure1/v/2024-02-22T141052Z/r/image-tiff Spinal cord injury-induced motor dysfunction is associated with neuroinflammation. Studies have shown that the triterpenoid lupenone, a natural product found in various plants, has remarkable anti-inflammatory effect context of chronic inflammation. However, effects lupenone on acute inflammation induced by spinal injury remain unknown. In this study, we established an impact-induced mouse model injury, and...
Gel electrophoresis is commonly used to separate DNA, but narrow capillaries or microchannels desired for high throughput efficient separations are difficult fill with gels. We report here that a capillary can be hydrodynamically wide size range of DNA fragments in single run without the need gels, wall coatings, an electric field. also demonstrate attractive separation possible few minutes and separated collected into individual fractions remain viable amplification via polymerase chain reaction.
Background: Fibroblast growth factor 21 (FGF21), a member of family atypical FGFs, function as cytokine to control endocrinology and metabolism. Recently, the roles FGF21 in cardio-cerebral-vascular diseases have been gradually uncovered. In present study, we investigated effect on bEnd.3 cerebral microvascular endothelial cells (CMECs) upon hypoxia stress. Methods Results: CMECs were cultured condition 1% O2 for 8 hours induce stimuli. For treatment, recombinant (50 nM) was added into...
Neuroinflammation plays an important role in the induction and maintenance of chronic pain. Orchestra pattern-recognition receptor-induced pro-inflammatory anti-inflammatory cytokines is critical for inflammation homeostasis. CD11b on macrophages could inhibit toll-like receptor (TLR) activation-induced inflammatory responses. However, function microglia remains unknown. In current study, we demonstrated that CD11b-deficient cells produced more cytokines, such as interleukin-6 tumor necrosis...
Dysmetabolic iron overload syndrome (DIOS) is frequently observed, but the underlying mechanism remains unclear. We propose hypothesis that hyperinsulinemia, a common characteristic of DIOS, may stimulate liver transferrin receptor 1 (TFR1) expression via PI3K/iron regulatory protein 2 (IRP2) pathway, leading to occurrence DIOS. The hepatic content, serum parameters, and expressions TFRs IRPs in were determined rats with temporary or long-lasting hyperinsulinemia induced by acute chronic...
Postoperative fatigue syndrome is a general complication after surgery. However, there no "gold standard" for assessment due to the lack of objective biomarkers. In this study, rodent model postoperative based on partial hepatectomy was firstly established and serum metabonomic method ultra-high performance liquid chromatography coupled with Q-TOF mass spectrometry applied. Partial least-squares discriminant analysis used identify differential metabolites in 70% rats relative sham 30% rats,...
Background Urinary extracellular vesicles (uEVs) are derived from epithelia facing the renal tubule lumen in kidney and urogenital tract; they may carry protein biomarkers of dysfunction structural injury. However, there scarce studies focusing on uEVs diabetes with Materials methods A community-based epidemiological survey was performed, participants were randomly selected for our study. enriched by dehydrated dialysis method, quantified Coomassie Bradford assay, adjusted urinary creatinine...
Schwann cells are the main force in spontaneous regeneration after peripheral nerve injury. The neurotrophic factors could promote regeneration, but clinical applications of these limited by some constraints. Hence, searching for new substances to elevate function and facilitate is urgently needed. Syringic acid (SA) a natural product with neuroprotective activity vivo, role SA on remains unclear. In this study, we first time found that was able proliferation migration cells, two important...
Type 2 diabetes constitutes a serious threat to the health of patients, but there is currently no ideal treatment in clinic. Glucagon-like peptide-1 and human umbilical cord mesenchymal stem cells have been confirmed antidiabetic effects, both them certain defects process antidiabetes, which cannot meet need clinical treatment. We hypothesized that can be used as vector construct novel cell line expresses GLP-1 vivo for long time. And this strain results lowering blood glucose type diabetic...