A5101594928- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Peripheral Nerve Disorders
- Urinary Bladder and Prostate Research
- Spinal Cord Injury Research
- Orthopedic Surgery and Rehabilitation
- Pelvic floor disorders treatments
- Ginkgo biloba and Cashew Applications
- Anesthesia and Neurotoxicity Research
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- DNA Repair Mechanisms
- Anesthesia and Pain Management
- Extracellular vesicles in disease
- Neuroscience of respiration and sleep
- Shoulder Injury and Treatment
- Foot and Ankle Surgery
- Wound Healing and Treatments
- Spinal Dysraphism and Malformations
- Neurofibromatosis and Schwannoma Cases
- DNA and Nucleic Acid Chemistry
- Pelvic and Acetabular Injuries
- Epigenetics and DNA Methylation
- Reconstructive Surgery and Microvascular Techniques
Shanghai Jiao Tong University
2019-2024
Shanghai First People's Hospital
2019-2024
State Key Laboratory of Molecular Oncology
2024
Peking University
2024
Second Military Medical University
2009-2019
Shanghai Changzheng Hospital
2011-2019
Guangzhou University
2017
Guangdong University Of Finances and Economics
2016
Guangdong University of Education
2016
Military University
2011
Transcription is extremely important for cellular processes but can be hindered by RNA polymerase II (RNAPII) pausing and stalling. Cockayne syndrome protein B (CSB) promotes the progression of paused RNAPII or initiates transcription-coupled nucleotide excision repair (TC-NER) to remove stalled RNAPII. However, specific mechanism which CSB TC-NER upon damage remains unclear. In this study, we identified indispensable role ARK2N–CK2 complex in CSB-mediated initiation TC-NER. The recruited...
Object Neurogenic bladder dysfunction following spinal cord injury (SCI) is a major medical and social problem for which there no ideal treatment strategy. In the present study, authors analyze effectiveness of neurogenic reinnervation in patients with SCIs by using Achilles tendon reflexes below paraplegic level. Methods Spinal root anastomoses were performed 12 hyperreflexic detrusor external sphincter dyssynergia (DESD) caused complete suprasacral SCI, an attempt to reinnervate bladder....
Axonal regeneration following peripheral nerve injury (PNI) depends on the complex interaction between Schwann cells (SCs) and macrophages, but mechanisms underlying macrophage recruitment activation in axonal remain unclear.RNA sequencing (RNA-seq) was conducted to identify differentially expressed long noncoding RNAs (DElncRNAs) crushed sciatic nerves intact contralateral nerves. The putative role of lncRNAs analyzed vitro vivo.An lncRNA, called axon regeneration-associated transcript...
Abstract Neurogenic bladder dysfunction following spinal cord injury is a major medical and social problem for which there no ideal treatment strategy. In this study, root anastomoses were performed in 10 paraplegic patients with traumatic lesions of the conus medullaris, an attempt to reinnervate paralyzed bladder. For operation, functional T11 ventral (VR) above lesion was transected anastomosed S2 roots unilaterally through nerve graft. The dorsal left intact as trigger micturition after...
Significance This study provides further proof for ZFP57 as a master regulator of genomic imprinting since it maintains DNA methylation at most known imprinted regions and regulates allelic expression the corresponding genes. We propose two alternate switch models ZFP57-dependent regulation parent-of-origin–dependent genes based on quantitative analyses Our results also shed light mechanistic link between imprint monoallelic The indicate that clustered through maintenance control regions.
Polyethylene glycol can connect the distal and proximal ends of an injured nerve at cellular level through axonal fusion to avoid Wallerian degeneration promote peripheral regeneration. However, this method only prevent in 10% axons because cytoskeleton is not repaired a timely fashion. Reconstruction cytoskeletal trunk microtubule network has been suggested be key for improving efficiency fusion. As microtubule-severing protein, spastin used enhance reconstruction. Therefore, we...
BACKGROUND Nerve transfer is a valid surgical procedure for lower-extremity function restoration after lumbosacral plexus avulsion. OBJECTIVE To evaluate the impact of severing L6 nerve root on functions healthy limb in rhesus monkeys and feasibility using contralateral as donor to repair METHODS Twenty-four were randomly assigned into 2 groups. In experimental group, right was explored severed, whereas control group animals underwent sham operation. Electrophysiology, muscle mass,...
Lower-limb function is severely impaired after sacral plexus nerve injury. Nerve transfer a useful reconstructive technique for proximal injuries.To investigate the clinical effectiveness and safety of transferring ipsilateral obturator to branch tibial innervating medial head gastrocnemius muscle recover knee ankle flexion.From 2007 2011, 5 patients with injury underwent as part strategy surgical reconstruction their plexuses. The mean patient age was 31.4 years (range, 19-45 years),...
Abstract The effect of Ginkgo biloba extract (EGb 50 ) on nerve regeneration and its dose–effect relationship was investigated in a rat model. Sciatic transection repair done 120 Sprague‐Dawley rats. animals were divided into four groups given normal saline, low‐dose EGb (50 mg kg −1 d ), moderate‐dose (100 high‐dose (200 respectively. Electrophysiological, histological examinations, functional evaluation conducted at various postoperative intervals. Sensory distance, sciatic index (SFI),...
Abstract Introduction: Neurogenic bladder dysfunction after spinal cord injury (SCI) is a major medical and social problem. In this study we assessed the effectiveness of neurogenic reinnervation in patients with SCI using normal S1 nerve root. Methods: Nine caused by to low conus medullaris (S2–S5) underwent novel surgical procedure which unilateral proximal end ventral root (VR) was anastomosed distal S2 S3 VRs. Results: Seven regained satisfactory control within 8–12 months VR...
Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins cytokines. After different peripheral injuries the rate can differ. Whether this is caused by differential expression of genes during remains unclear. The right tibial common peroneal same rat were exposed completely cut through then sutured in horizontal plane. On days 1, 7, 14, 21 surgery, 1-2 cm tissue distal to suture site was dissected out from nerves. differences gene protein...
Among the many difficult problems presented by patients with spinal cord injuries, management of ischial pressure ulcers remains challenging for reconstructive surgeons. This study describes long-term outcome using posterior-thigh fasciocutaneous flaps treatment sores. Between January 1999 and June 2003, 12 sores were enrolled in this study. All underwent early aggressive surgical debridement followed reconstruction a laterally based flap. The follow-up period ranged from 24 months to 97...
Nerve transfer is used for brachial plexus injuries but has rarely been applied to repairs in the lower extremities. The aim of this study was evaluate feasibility and effectiveness using contralateral L-6 nerve root repair lumbosacral avulsions.Eighteen rhesus monkeys were randomized into 3 groups. In experimental group, left L4-7 S-1 roots avulsed right transferred inferior gluteal sciatic branch innervating hamstrings. control not performed. sham operation animals underwent a procedure...