A5101646253- Pain Mechanisms and Treatments
- Cervical Cancer and HPV Research
- Inflammasome and immune disorders
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Liver Disease and Transplantation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Eicosanoids and Hypertension Pharmacology
- Advanced biosensing and bioanalysis techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Galectins and Cancer Biology
- Viral Infections and Vectors
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Pregnancy and preeclampsia studies
- Biochemical Acid Research Studies
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- Mechanisms of cancer metastasis
- Neuroscience and Neuropharmacology Research
- Phagocytosis and Immune Regulation
Shanghai Changzheng Hospital
2021-2024
Shenyang Pharmaceutical University
2024
Third Hospital of Hebei Medical University
2024
Hebei Medical University
2024
Nanjing Medical University
2009-2020
Nanjing Maternity and Child Health Care Hospital
2009-2020
First Affiliated Hospital of Xi'an Jiaotong University
2019-2020
Second Military Medical University
2017
Nanjing University
2009-2010
Nanjing Traditional Chinese Medicine Hospital
2010
Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to relieve neuropathic other diseases as a promising cell-free therapeutic strategy. However, value huc-MSCs-derived in complete Freund's adjuvant (CFA)-induced remains be confirmed. this study, we investigated effect related mechanisms chronic model.C57BL/6J male mice were establish...
Macroautophagy/autophagy, an evolutionarily conserved process, plays important role in the regulation of immune inflammation and nervous system homeostasis. However, exact mechanism autophagy pain is still unclear. Here, we showed that impaired flux mainly occurred astrocytes during maintenance neuropathic pain. No matter stage induction or maintenance, activation relieved level pain, whereas inhibition aggravated Moreover, levels neuroinflammation reactive oxygen species (ROS) were...
Chronic pain, such as persistent inflammatory remains a public health problem that has no effective treatment at present. Bromodomain-containing protein 4 (BRD4) inhibition, induced by JQ1 injection or BRD4 knockdown, been used to attenuate pain; However, it elusive whether aggravates pain regulating inflammasome. Western blot and immunofluorescence staining showed expression increased after administration of complete Freund’s adjuvant (CFA) reached its peak on day 3. Immunofluorescence was...
Epoxyeicosatrienoic acids with anti-inflammatory effects are inactivated by soluble epoxide hydrolase (sEH). Both sEH and histone deacetylase 6 (HDAC6) inhibitors being developed as neuropathic pain relieving agents. Based on the structural similarity, we designed a new group of compounds inhibition both HDAC6 obtained compound
Abstract Chronic varicella zoster virus (VZV) infection induced neuroinflammatory condition is the critical pathology of post-herpetic neuralgia (PHN). The immune escape mechanism VZV remains elusive. As to mice have no receptor, herpes simplex type 1 (HSV-1) a well established PHN model. Transcriptional expression analysis identified that protein arginine methyltransferases 6 (Prmt6) was upregulated upon HSV-1 infection, which further confirmed by immunofluorescence staining in spinal...
The pro-inflammatory phenotype of microglia usually induces neuroinflammatory reactions in neuropathic pain. Glycometabolism shift to glycolysis can promote the transition microglia. omics data analysis suggest a critical role for Lyn dysregulation present study aimed at exploring mechanism Lyn-mediated enhancement Neuropathic pain model was established by chronic constriction injury (CCI), then thresholds and expression were measured. inhibitor Bafetinib siRNA-lyn knockdown administrated...
Microglia induced chronic inflammation is the critical pathology of Neuropathic pain (NP). Metabolic reprogramming macrophage has been intensively reported in various diseases. However, metabolic microglia remains to be elusive. Here, we that immuno-metabolic markers (HIF-1α, PKM2, GLUT1 and lactate) were related with increased expression PRMT6 ipsilateral spinal cord dorsal horn construction injury (CCI) mice. deficiency or prophylactic therapeutic intrathecal administration inhibitor...
MicroRNAs (miRNAs) have emerged as critical regulators of neuronal survival during cerebral ischaemia/reperfusion injury. Accumulating evidence has shown that miR-199a-5p plays a crucial role in regulating apoptosis and various cell types. However, whether miR-199a is involved injury remains unknown. In this study, we aimed to explore the biological induced by oxygen-glucose deprivation/reoxygenation (OGD/R), an vitro cellular model ischaemia reperfusion We found expression was significantly...
Hyperglycemia-induced neuroinflammation significantly contributes to diabetic neuropathic pain (DNP), but the underlying mechanisms remain unclear.
Abstract Purpose: This randomized, controlled trial was designed to determine whether the DNA cytometry testing is superior conventional cytologic for mass cervical cancer screening. Experimental Design: After approval by institutional ethics review boards from three separate screening centers, a total of 23,993 Chinese women ages 20 65 years were randomly assigned into one two groups: group (11,999 women) and (11,994 women). Each woman underwent other after first attending test. Women with...
Spinal cord injury (SCI) is a devastating trauma characterized by serious neuroinflammation and permanent neurological dysfunction. However, the molecular mechanism of SCI remains unclear, few effective medical therapies are available at present. In this study, multiple bioinformatics methods were used to screen out novel targets for SCI, these candidates during progression as well therapeutic effects both verified in rat model traumatic SCI. As result, CASP4, IGSF6 IL1R1 identified...
// Zhengna Yin 1, * , Mengyun Gao Sasa Chu 2 Yiping Su 1 Chunping Ye Yiquan Wang 3 Zhuanqin Pan 4 Zhuming 5 Huilin Zhang Hua Tong and Jin Zhu 6 Department of Obstetrics Gynecology, Nanjing Maternity Child Health Care Hospital, Gynecology Hospital Affiliated to Medical University, 210004, China Infectious Disease, Institute Liver Jingdu 210002, Traditional Chinese Internal Medicine, Longhua Shanghai University 200071, Nursing, Gaoyou People’s Yangzhou 225600, Pathology, Ministry...
Abstract Chronic periodontitis (CP) is a common oral disease characterized by the slow progression of alveolar attachment loss and bone destruction. Genetic components have been reported to play an important role in onset development CP. In present study, we aimed replicate association signals NIN SIGLEC5 identified previous genome-wide studies (GWASs) samples from Chinese Han individuals. Association between clinical severity indicators CP relevant single nucleotide polymorphisms (SNPs)...
Background/Aims: Benzotriazole (BTR) and its derivatives, such as intermediates UV stabilizers, are important man-made organic chemicals found in everyday life that have been recently identified environmental toxins a threat to female reproductive health. Previous studies shown BTR could act carcinogen by mimicking estrogen. Environmental estrogen mimics promote the initiation development of cancers, endometrial carcinoma, type estrogenic-sensitive malignancy. However, there is little...
Over-expression of Receptor-tyrosine-kinase-like Orphan Receptor 1 (ROR1) in cancer cells has been reported the context several tumors (including ovarian cancer) and is associated with poor prognosis. The aim this study was to construct a fully chimeric anti-ROR1 IgG antibody (ROR1-IgG) investigate its antitumor activity against cells, bothin vitro vivo. A eukaryotic expression vector constructed ROR1-IgG expressed CHO cells. characteristics were investigated by ELISA, SPR, Western blotting,...