A5012501036- Ovarian function and disorders
- Reproductive Biology and Fertility
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Pluripotent Stem Cells Research
- CCD and CMOS Imaging Sensors
- Sperm and Testicular Function
- Immunotherapy and Immune Responses
- Advanced Memory and Neural Computing
- PI3K/AKT/mTOR signaling in cancer
- Advanced biosensing and bioanalysis techniques
- Coronary Artery Anomalies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer Immunotherapy and Biomarkers
- Remote Sensing and Land Use
- Toxin Mechanisms and Immunotoxins
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Simulation and Modeling Applications
- Kawasaki Disease and Coronary Complications
- Endometriosis Research and Treatment
- Satellite Image Processing and Photogrammetry
Zhaotong University
2024
Nanjing Maternity and Child Health Care Hospital
2009-2023
Nanjing Medical University
2013-2023
Qinghai University
2023
Foundation for Ichthyosis and Related Skin Types
2015
Zhejiang Museum of Natural History
2005
The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a transmembrane protein belongs to tyrosine kinase (RTK) family. This study aimed examine the expression of ROR1 in human ovarian cancer and investigate relationship between its prognosis patients. In this present study, one-step quantitative reverse transcription-polymerase chain reaction (15 samples high FIGO stage, 15 low stage nine normal ovary tissue samples) immunohistochemistry by microarrays (100 50 were performed...
It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout reproductive life. Intra-oocyte PI3K/mTOR pathways have indicated to play a central role on activation of follicles. Genetic modified mouse models chronic signals oocytes showed premature all eventually their exhaustion. On other hand, this may suggest that, unlike PI3K/mTOR, its acute infertility would activate follicles, permitting...
In mammalian ovaries, follicle assembly requires proper germ cell cyst breakdown and the invasion of somatic cells to encapsulate individual oocytes. Abnormalities in this process lead a number pathologies such as premature ovarian failure infertility. As conserved pathway regulating growth metabolism response factors nutrients, roles mTOR signaling follicular development have been extensively studied recent years. However, its functions during formation remain unknown. study, expression...
Our previous studies have suggested that the primary impact of immune cell infiltration into normal or pre-invasive tissue component is associated with physical destruction epithelial capsules, which may promote tumor progression and invasion. current study attempted to further verify our observations determine type(s) infiltrating cells possible mechanism destructions capsules. In total, was conducted 250 breast prostate tumors, cytotoxic T-lymphocytes (CTL), Natural killer (NK) Mast were...
Abstract In mammalian ovaries, primordial follicles remain in a quiescent state until activation by the surrounding microenvironment. Ovarian intervention, for example, ovarian cystectomy, wedge resection or laser drilling therapies polycystic syndrome, has long been reported to change follicular development an unknown mechanism(s). Herein, we established murine model with partial of one ovary unilaterally, contralateral undamaged. We found injury accelerated and through mTORC1 signaling...
// Zhengna Yin 1, * , Mengyun Gao Sasa Chu 2 Yiping Su 1 Chunping Ye Yiquan Wang 3 Zhuanqin Pan 4 Zhuming 5 Huilin Zhang Hua Tong and Jin Zhu 6 Department of Obstetrics Gynecology, Nanjing Maternity Child Health Care Hospital, Gynecology Hospital Affiliated to Medical University, 210004, China Infectious Disease, Institute Liver Jingdu 210002, Traditional Chinese Internal Medicine, Longhua Shanghai University 200071, Nursing, Gaoyou People’s Yangzhou 225600, Pathology, Ministry...
Background/Aims: The aim of this study was to develop a novel model by transplanting human bladder cancer xenografts into humanized immunodeficient mice (SCID). Methods: animals first underwent sublethal irradiation and then were subjected simultaneous transplantation lymphocytes (5 × 107 cells/mouse i.p.) cells (3 106 s.c.). Results: developed in all 12 that had received BIU-87 cells, the tumor specimens evaluated histologically. All 6 expressed CD3 mRNA and/or protein peripheral blood,...
Premature ovarian insufficiency (POI) is characterized by symptoms caused dysfunction in patients aged <40 years. It associated with a shortened reproductive lifespan. The only effective treatment for who are eager to become pregnant IVF/Embryo Transfer (ET) using oocytes donated young women. However, the use of technique constrained limited supply and ethical issues. Some POI still have some residual follicles cortex, which not regulated gonadotropin. These dormant. Therefore, activating...
Over-expression of Receptor-tyrosine-kinase-like Orphan Receptor 1 (ROR1) in cancer cells has been reported the context several tumors (including ovarian cancer) and is associated with poor prognosis. The aim this study was to construct a fully chimeric anti-ROR1 IgG antibody (ROR1-IgG) investigate its antitumor activity against cells, bothin vitro vivo. A eukaryotic expression vector constructed ROR1-IgG expressed CHO cells. characteristics were investigated by ELISA, SPR, Western blotting,...
Abstract Premature ovarian failure (POF) is a complication of dysfunction resulting from the depletion or primordial follicles (PFs) in ovaries. However, residual that have potential to be activated are present POF aged women. Little known about mechanisms by which remaining dormant PFs patients activated. Using mass spectrometry, we screened differentially generated peptides extracted cortical tissue biopsies with without POF, during identified PFAP1, peptide significantly promoted...
Spike-timing mechanisms in neuromorphic vision sensors represent a cutting-edge approach to mimicking biological systems' efficiency and adaptability. These systems utilize memristor-based non-volatile memory devices achieve high precision low power consumption, essential for real-time image processing recognition tasks. This paper explores the principles applications of spike-timing-dependent plasticity (STDP) sensors, focusing on integration memristor technology. study introduces an...
Spike-timing mechanisms in neuromorphic vision sensors represent a cutting-edge approach to mimicking biological systems' efficiency and adaptability. These systems utilize memristor-based non-volatile memory devices achieve high precision low power consumption, essential for real-time image processing recognition tasks. This paper explores the principles applications of spike-timing-dependent plasticity (STDP) sensors, focusing on integration memristor technology. study introduces an...
Population-wide, paraganglioma (PGL) is uncommon. The incidence of Takotsubo syndrome (TTS) ranges from 0.5% to 0.9% and also an exceedingly rare manifestation PGL. Coronary artery ectasia (CAE) uncommon, with ranging 1.2% 4.9%. Herein, we present a case PGL, TTS, Markis type I CAE that occured in the same patient.A man his early 40s was admitted our hospital 16-hour history abdominal colic. Computed tomography laboratory examination led diagnosis coronary angiography or Chinese III CAE, two...
光热协同催化是一种有效提升活化过一硫酸盐(PMS)高级氧化催化效率的方法。然而，对于常见的过渡金属基催化剂来说，反应过程中常常发生有毒金属离子溶出，限制了这类催化剂在实际水处理中的应用。因此，开发具有高效活化PMS能力的非金属基催化剂至关重要。采用溶胶-热还原法制备一种新型氮化碳锚定FeOx纳米复合物(FeOx/CN)类芬顿催化剂。采用X射线衍射仪、扫描电子显微镜、透射电子显微镜、X射线光电子能谱、氮气吸附-脱附仪和紫外-可见漫反射吸收光谱等测试手段对复合材料的结构、形貌和光吸收性质进行表征。考察光热协同作用下FeOx/CN催化剂活化PMS氧化降解罗丹明B(RhB)的效果。结果表明：在近中性(pH=6)条件下，光热(水浴40 ℃，λ>420 nm光照)协同辅助反应30 min，CN/FeOx/PMS体系对RhB的去除率达到98.0%。活性自由基捕获实验证明，空穴(h+)和羟基自由基(OH·)在污染物降解中起到决定性作用。