A5101744288- Extracellular vesicles in disease
- Spinal Cord Injury Research
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Circular RNAs in diseases
- Ocular Surface and Contact Lens
- Adipokines, Inflammation, and Metabolic Diseases
- Spinal Fractures and Fixation Techniques
- Ophthalmology and Visual Impairment Studies
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Nerve Injury and Rehabilitation
- Retinal Diseases and Treatments
- Acute Ischemic Stroke Management
- Natural Antidiabetic Agents Studies
- Hippo pathway signaling and YAP/TAZ
Nanjing Medical University
2019-2025
Shandong Eye Hospital
2024-2025
Shandong First Medical University
2024-2025
Jiangsu Province Hospital
2019-2024
Beijing Institute of Technology
2024
Dalian Medical University
2017-2022
Guilin Medical University
2021-2022
Soochow University
2022
Second Affiliated Hospital of Nanjing Medical University
2022
Nanxi Mountain Hospital
2021
Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potential for promoting functional behavioral recovery following SCI. However, MSCs are usually exposed normoxia in vitro, which differs greatly from the hypoxic micro-environment vivo. Thus, main purpose of this study was determine whether derived under hypoxia (HExos) exhibit greater effects on...
Abstract Background Spinal cord injury (SCI) is a catastrophic that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role intercellular communication via transfer genetic material. However, exosomes which derived from neurons, underlying mechanisms by they contribute to SCI remain unknown. Methods A contusive vivo model series vitro experiments were carried out explore therapeutic effects exosomes. Then,...
Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized are dominant play a crucial role throughout whole SCI process. The aim our study was investigate effects bone marrow-derived (M1-BMDMs) on vascular endothelial cells their underlying mechanism. Microvascular cell line bEnd.3 were treated with...
Spinal cord injury (SCI) is a severe traumatic disease which causes high disability and mortality rates. The molecular pathological features after spinal mainly involve the inflammatory response, microglial neuronal apoptosis, abnormal proliferation of astrocytes, formation glial scars. However, microenvironmental changes are complex, interactions between cells nerve remain unclear. Small extracellular vesicles (sEVs) may play key role in cell communication by transporting RNA, proteins,...
Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1 diabetes. Because little is known about its absorption and humans, we investigated the pharmacokinetics pharmacodynamics healthy volunteers. Twelve subjects were subjected to an open-labeled, three-period trial involving sequential oral administration placebo, 2 g once, three times/day for 7 days, with a 7-day washout between each period. was rapidly absorbed (Tmax: 0.5 ~ h) half-life (t1/2) 5 h. No...
Abstract Osteosarcoma (OS) is a malignant bone tumor which occurs mainly in adolescents with frequent pulmonary metastasis and high mortality rate. Accumulating evidence has indicated that microRNAs (miRNAs) play vital role various tumors by modulating target genes as well signal pathways, aberrant expression of miRNAs may contribute to OS progression. This study aimed determine the association between miR-210-5p progression investigate its potential underlying mechanism. Using reverse...
Neural stem cell-derived small extracellular vesicles (NSC-sEVs) play an important role in the repair of tissue damage. Our previous vitro and vivo studies found that preconditioning with NSC-sEVs promoted recovery functional behaviors following spinal cord injury by activating autophagy. However, underlying mechanisms for such observations remain unclear. In this study, we further explored which via We contain 14-3-3t protein, overexpression or knockdown enhanced decreased autophagy,...
Increasing evidence indicates that lymphocyte cytosolic protein 1 (LCP1) overexpression contributes to tumor progression; however, its role in osteosarcoma (OS) remains unclear. We aimed investigate the potential effect of LCP1 OS and underlying mechanisms. first demonstrated is upregulated cell lines tissues. Then, we found aberrant expression could induce proliferation metastasis cells vitro vivo by destabilizing neuregulin receptor degradation protein-1 (Nrdp1) subsequently activating...
Abstract Background Spinal cord injury (SCI) has a very disabling central nervous system impact but currently lacks effective treatment. Bone marrow-derived macrophages (BMDMs) are recruited to the injured area after SCI and participate in regulation of functional recovery with microglia. Previous studies have shown that M2 microglia-derived small extracellular vesicles (SEVs) neuroprotective effects, effects BMDM-derived sEVs (M2 BMDM-sEVs) not been reported Results In this study, we...
Accumulating evidence indicates that aberrant microRNA (miRNA) expression contributes to osteosarcoma progression. This study aimed elucidate the association between miR-624-5p and (OS) development investigate its underlying mechanism. We analyzed GSE65071 from GEO database found was most upregulated miRNA. The of specific target gene were determined in human OS specimens cell lines by RT-PCR western blot. effects depletion or ectopic on proliferation, migration invasion evaluated vitro...
RNA N6-methyladenosine (m6A) modification is involved in diverse biological processes. However, its role spinal cord injury (SCI) poorly understood. The m6A level increases injured cord, and METTL3, which the core subunit of methyltransferase complex, upregulated reactive astrocytes further stabilized by USP1/UAF1 complex after SCI. specifically binds to subsequently removes K48-linked ubiquitination METTL3 protein maintain stability Moreover, conditional knockout astrocytic both sexes mice...
To investigate seasonal variations in changes of axial length (AL) among myopic children wearing orthokeratology (ortho-K) lenses. The data 600 receiving ortho-K treatment, aged 7-13 years, were collected retrospectively. Data classified as 'summer' or 'winter' based on the midpoint 6-month period between visits. For each interval, AL from right eye was used for statistical analysis. Paired sample t-tests to compare differences AL. Furthermore, relationship AL, age and initial analysed using...
Schatzker IV-VI tibial plateau fractures usually happen in the weight-bearing part of knee joint. They are hard to fix with traditional methods because they damage soft tissues and make it get back normal activities. This study introduces a modified hockey-stick medial plate (mHSMP) designed improve functional outcomes while reducing surgical complexity. retrospective included 40 patients (20 experimental group treated mHSMP 20 control plate) who were followed up for 12 months. Surgical...
Neuroinflammation following spinal cord injury usually aggravates damage. Many inflammatory cytokines are key players in neuroinflammation. Owing largely to the multiplicity of cytokine targets and complexity interactions, it is insufficient suppress damage progression by regulating only one or a few cytokines. Herein, we propose two-pronged strategy simultaneously capture released inhibit synthesis new ones broad-spectrum manner. To achieve this strategy, designed core/shell-structured...
Abstract Reactive astrogliosis is a pathological feature of spinal cord injury (SCI). The ubiquitin‐proteasome system plays crucial role in maintaining protein homeostasis and has been widely studied neuroscience. Little, however, known about the underlying function deubiquitinating enzymes reactive following SCI. Here, we found that ubiquitin‐specific protease 18 (USP18) was significantly upregulated astrocytes scratch injury, injured mice. Knockdown USP18 vitro conditional knockout (USP18...
GLP-1, an important incretin hormone plays role in the regulation of glucose homeostasis. However, therapeutic use native GLP-1 is limited due to its short half-life. We recently developed a novel mimetics (supaglutide) by genetically engineering recombinant fusion protein production techniques. demonstrated that this formulation possessed long-lasting actions and was effective glycemic control both type 1 2 diabetes rodent models. Here, we investigated effects supaglutide regulating energy...
Ischemia-reperfusion injury (IRI) is a serious complication of hepatectomy and liver transplantation. The aim this study was to evaluate the protective effects salvianolic acid-A (Sal-A) against IRI-induced hepatocellular injury.Forty rats were randomly divided into following four groups: (1) sham group, (2) IR (3) Sal-A(10) group (4) Sal-A(20) group. After 90 min ischemia 6 h reperfusion, serum alanine aminotransferease (ALT) apartate aminotransferase (AST) levels measured; amounts...