A5100381107- Plant Reproductive Biology
- Mesenchymal stem cell research
- Genetic and phenotypic traits in livestock
- Genetic Associations and Epidemiology
- Kruppel-like factors research
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Polysaccharides and Plant Cell Walls
- Mitochondrial Function and Pathology
- Bone Tissue Engineering Materials
- Spinal Cord Injury Research
- Protein Degradation and Inhibitors
- Metabolism and Genetic Disorders
- Photosynthetic Processes and Mechanisms
- Osteoarthritis Treatment and Mechanisms
- CAR-T cell therapy research
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Plant Gene Expression Analysis
- ATP Synthase and ATPases Research
- Retinal Development and Disorders
- Retinal Diseases and Treatments
Sun Yat-sen University
2024
First Hospital of Lanzhou University
2023
Lanzhou University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Sichuan University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Wenzhou Medical University
2023
Shenyang University of Chemical Technology
2023
Northwest University
2022
Southwest University
2022
Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized are dominant play a crucial role throughout whole SCI process. The aim our study was investigate effects bone marrow-derived (M1-BMDMs) on vascular endothelial cells their underlying mechanism. Microvascular cell line bEnd.3 were treated with...
The integrity of pollen wall structures is essential for development and maturity in rice (Oryza sativa L.). In this study, we isolated characterized the male-sterile mutant abortion 1 (pwa1), which exhibits a defective (DPW) structure has sterile pollen. Map-based cloning, genetic complementation, gene knockout experiments revealed that PWA1 corresponds to LOC_Os01g55094 encoding coiled-coil domain-containing protein. localized nucleus, was expressed tapetum microspores. interacted with...
The relative contributions of additive versus non-additive interactions in the regulation complex traits remains controversial. This may be part because large-scale epistasis has traditionally been difficult to detect complex, multi-cellular organisms. We hypothesized that it would easier using mouse chromosome substitution strains simultaneously incorporate allelic variation many genes on a controlled genetic background. Analyzing metabolic and gene expression levels offspring series...
Aim: To investigate the effect of cartilage extracellular matrix (ECM) particle size on chondrogenic differentiation bone marrow-derived mesenchymal stem cells (BMSCs). Materials & methods: BMSCs were seeded into scaffolds fabricated by small ECM materials and large materials. For positive control, chondrogenically induced commercial poly-lactic-glycolic acid scaffolds. Macroscopic observation, histological immunohistochemical staining, mechanical testing biochemical analysis performed to...
Abstract Background Kruppel-like factor 13 (KLF13) is a transcription and plays an important role in carcinogenesis. However, the significance of KLF13 thyroid carcinoma (THCA) underdetermined. In this study, we aimed to explore clinical relevance function progress THCA. Methods The expression normal tissue was investigated by qPCR IHC assay. IFIT1 cell samples with Western blot Cell proliferation ability detected CCK8 colony formation growth vivo or without overexpression evaluated on...
The bromodomain-containing 4 (BRD4) is a member of the bromodomain and extra terminal domain (BET) family, which an important epigenetic reader. It currently promising oncology target. In some tumors, BET inhibitors have demonstrated results. Proteolysis-targeting methods (PROTAC), rapidly effectively degrade BRD4, displayed considerable potential in treatment tumors recent years. purpose this study to examine impact BRD4 PROTAC compounds ARV-825 on oncogene BRD4-NUT fused protein NUT...
Abstract The relative contributions of additive versus non-additive interactions in the regulation complex traits remains controversial. This may be part because large-scale epistasis has traditionally been difficult to detect complex, multi-cellular organisms. We hypothesized that it would easier using mouse chromosome substitution strains simultaneously incorporate allelic variation many genes on a controlled genetic background. Analyzing metabolic and gene expression levels offspring...
<title>Abstract</title> <bold>purpose:</bold>Maternally Inherited Leigh Syndrome (MILS) is a group of systemic diseases caused by defects in mitochondrial oxidative phosphorylation (OXPHOS). We aim to investigate the clinical and genetic characteristics MILSpedigree with MT-ATP6 mutation who were first diagnosed RP.<bold>Methods:</bold>This study included family pedigree consisting proband visual blurring symptoms, his mother similar father was asymptomatic. The medical history asked, best...