A5100388596- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Advanced Glycation End Products research
- Cancer Mechanisms and Therapy
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Hydrogen's biological and therapeutic effects
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Cardiovascular Function and Risk Factors
- Circular RNAs in diseases
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Medicinal Plants and Bioactive Compounds
- Apelin-related biomedical research
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
East China Normal University
2025
Erasmus MC
2023-2024
Delft University of Technology
2024
Lanzhou University
2012-2023
First Hospital of Lanzhou University
2013-2023
First Affiliated Hospital of Wenzhou Medical University
2023
Wenzhou Medical University
2023
Shanghai Jiao Tong University
2022
Shihezi University
2022
Duke University
2022
There is limited information on prevalent and incident atrial fibrillation in Chinese. We aimed to investigate the prevalence, incidence, management risks of an elderly Chinese population. In a population—based prospective study (≥60 years) Chinese, we performed cardiovascular health examinations including 12-lead electrocardiogram at baseline 3,922 participants biennially during follow-up 2,017 participants. collected vital status whole period. The prevalence was 2.0 % (n = 34) 1718 men 1.6...
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance currently available therapies. Here, we identified REGγ as a mutant KRAS–associated factor that enhanced transcription through intermediate NRF2, suggesting REGγ-proteasome is potential target for pan-KRAS inhibitor development. We elucidated mechanism involving KRAS/NRF2/REGγ regulatory axis, which links activated ATP- and ubiquitin-independent proteasome. subsequently developed...
Abstract Atrial Fibrillation (AF) is common in the elderly and Sestrins (Sesns) have been suggested to prevent age-related pathologies. The aim of this study was investigate effects Sesns AF. Clinical data were collected a small sample atrial appendage atrium obtained from patients undergoing valve repairment. expression Sesn1, Sesn2, Sesn3 significantly higher with permanent fibrillation (PmAF) than that sinus rhythm (SR), further greater left right PmAF patients. Superoxide anion...
Pleckstrin homology-like domain family A, member 3 (PHLDA3) has a particularly critical role in regulating cell survival under stress conditions. However, whether PHLDA3 plays myocardial ischemia/reperfusion injury not been studied. We aimed to assess the possible of (I/R) injury. expression was increased tissue from rats with I/R and rat cardiomyocytes hypoxia/reoxygenation (H/R) knockdown protected against vivo H/R vitro. Inhibition activation nuclear factor erythroid-derived 2-related 2...
Patients with persistent atrial fibrillation (AF) have more electrical endo-epicardial asynchrony (EEA) during sinus rhythm (SR) than patients without AF. Prior mapping studies indicated that particularly unipolar, endo- and/or epicardial electrogram (EGM) morphology may be indicators of EEA. This study aim to develop a novel method for estimating the degree EEA by using unipolar EGM characteristics recorded from either epicardium. Simultaneous was performed in 86 patients. characteristics,...
(1) Background: Structural remodeling plays an important role in the pathophysiology of atrial fibrillation (AF). It is likely that structural occurs transmurally, giving rise to electrical endo-epicardial asynchrony (EEA). Recent studies have suggested areas EEA may be suitable targets for ablation therapy AF. We hypothesized degree more pronounced transmural conduction block (T-CB) than single-sided CB (SS-CB). This study examined which SS-CB and T-CB enhance specific unipolar potential...
The aim of the present study was to compare conventional right ventricular apical pacing (RVAP) with mid-septal (RVMSP) in terms echocardiographic and clinical/biologic features. Ninety-six patients high-degree atrioventricular block were randomly allocated RVMSP (n = 50) RVAP 46). Threshold impedance, left ejection fraction, dyssynchrony features, distance during a 6-min walk test Minnesota Living Heart Failure Questionnaire determined at 6 12 months after pacemaker implantation. Serum...
Peroxisome proliferator-activated receptor α is a member of the nuclear superfamily. It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro. In this study, we tested hypothesis that PPAR would decrease expression monocyte chemoattractant protein-1 tissue factor, inhibit neointimal formation murine double carotid artery injury model. Carotid was performed knockout wild type (WT) mice, treated untreated with Wy14643, activator. Up-regulated MCP-1 TF more were...
Dextrocardia is a rare congenital condition (1/10,000-12,000) and AF uncommon (1-2%). Therefore, the occurrence of two conditions rare. Percutaneous left atrial appendage occlusion (LAAO) treatment to prevent fibrillation (AF)-associated thromboembolic events.An 85-year-old female with known situs inversus totalis, persistent AF, stroke was treated oral anticoagulation, but she suffering from constant gingival bleeding. Her CHA2DS2VASc score 6 points (abnormal, ≥ 2), her HAS-BLED 4 3). The...
Objective To investigate the application value of transesophageal echocardiography (TEE) in patients with nonvalvular atrial fibrillation about size, lobes, morphology and function left appendage (LAA). Methods One hundred forty-two underwent TEE were divided into group (98 cases) non (44 cases). The orifice diameter, depth, volume, peak emptying velocity (PEV) LAA 1eft dimension (LAD) measured. form lobes LAA, thrombus spontaneous echo contrast (SEC) observed. Results The...
<title>Abstract</title> <bold>purpose:</bold>Maternally Inherited Leigh Syndrome (MILS) is a group of systemic diseases caused by defects in mitochondrial oxidative phosphorylation (OXPHOS). We aim to investigate the clinical and genetic characteristics MILSpedigree with MT-ATP6 mutation who were first diagnosed RP.<bold>Methods:</bold>This study included family pedigree consisting proband visual blurring symptoms, his mother similar father was asymptomatic. The medical history asked, best...
Objective To investigate the right ventricular morphology and function of patients with atrial septal defects by single beat real-time three-dimensional echocardiography.Methods Thirty-four healthy volunteers twenty-seven ASD were enrolled consecutively as normal controls group respectively.Single cardiac cycle three dimensional echocardiography was performed in all to evaluate parameters concerning modality systolic participants' ventricle.The relationship indexed end diastolic volume...
Objective To investigate the characteristics and associated factors of ventricular arrhythmias in patients with chronic heart failure. Methods Two hundred forty two failure reduced left ejection fraction (HF-REF) without hemodynamic disorder were consecutively enrolled Armed police general hospital from January 2014 to October 2016. Left diastolic ending internal diameter, (LVEF) E/A values assessed by cardiac ultrasound. Premature contractions (PVCs), bigeminy, frequent PVCs,...
Background: Foramen ovale is a residual cavity in the developing heart fetus. At present, standard methods for diagnosis of PFO-right-to-left-shunting (PFO-RLS) include transesophageal echocardiography (TEE), contrast-transcranial Doppler (C-TCD), and contrast-transthoracic (C-TTE), each them having its advantages disadvantages.However, there are no data allowing comparison these three methods. Methods: We systematically reviewed all published studies on patients with cryptogenic cerebral...
Mirror-image dextrocardia is non-life-threatening but not commonly diagnosed in the clinic. With internal organs reversed, most of patients with mirror-image have no clinical symptoms if combined other intracardiac malformations. often discovered during physical check or performing examinations. In present study, we reported a successful closure left atrial appendage an 84-year-old patient fibrillation under guidance transesophageal echocardiography (TEE). Detailed perioperative steps...