Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when blood supply restored after period ischemia. Reperfusion can be achieved either by thrombolysis using thrombolytic reagents such as tissue plasminogen activator (tPA), or through mechanical removal thrombi. Spontaneous reperfusion also stroke. However, despite the beneficial effect oxygen reperfusion, it causes deleterious compared with permanent With recent advancement in endovascular therapy including...

Purpose To evaluate the repeatability, reproducibility, and agreement of thickness profile measurements eight intra-retinal layers determined by an automated algorithm applied to optical coherence tomography (OCT) images from two different instruments. Methods Twenty normal subjects (12 males, 8 females; 24 32 years old) were enrolled. Imaging was performed with a custom built ultra-high resolution OCT instrument (UHR-OCT, ∼3 µm resolution) commercial RTVue100 (∼5 instrument. An developed...

To evaluate the visual quality of patients with different angle κ sizes after a trifocal diffractive intraocular lens (IOL) implantation.The Affiliated Hospital Qingdao University, Qingdao, China.Prospective case series.Patients who had phacoemulsification implantation IOL AT LISA tri 839MP were enrolled in study. The divided into 3 groups based on size preoperative κ. Monocular far, intermediate, and near uncorrected acuities measured during 3-month follow-up. Other outcome measurements...

To examine the current status of research, identify key areas interest, and explore emerging frontiers in field scleral lenses (SL) with goal informing advancing further research this field. Bibliometric methods were utilized to retrieve SL-related literature published Web Science Scopus database from 2014 2024. Elements such as authors, country/region, institution, journal, keywords analyzed using CiteSpace information visualization analysis software Bibliometrix R package. A total 506...

To investigate seasonal variations in changes of axial length (AL) among myopic children wearing orthokeratology (ortho-K) lenses. The data 600 receiving ortho-K treatment, aged 7-13 years, were collected retrospectively. Data classified as 'summer' or 'winter' based on the midpoint 6-month period between visits. For each interval, AL from right eye was used for statistical analysis. Paired sample t-tests to compare differences AL. Furthermore, relationship AL, age and initial analysed using...

We have determined the amino acid sequence of variable (V) region delta heavy (H) chain human IgD isolated from plasma myeloma patient WAH. This V is unusual in its end group (arginine) and length (129 residues). The due to 10 insertions third complementarity-determining (CDR3). A computer search showed that no reported CDR3-joining (-JH) sequences are identical they appear be unrelated constant (C) immunoglobulins. together with our previous results for C give complete WAH, which has 512...

Purpose The aim of this study was to characterize the temporal and spatial distribution myopia among students aged 7–18 years, by analyzing aggregation area providing basis for prevention control in China. Methods A database analysis China during 1995–2014 established using ArcGIS10.0 software as a platform data management presentation. autocorrelation undertaken, scan performed SaTScan9.5 software. Results Our demonstrated that prevalence 1995, 2000, 2005, 2010, 2014 35.9, 41.5, 48.7, 57.3,...

A strategy for the proteolytic fragmentation of human IgM has been developed. This method is called "cold pepsin digestion" because its unique feature achieving restricted peptic cleavages at 4 degrees and pH 4.0. Cold digestion applied successfully to produce an Fv fragment from 14 proteins. The consists heavy chain variable domain (VH) light (VL) held together by strong noncovalent interaction. Thus, each contains one intact antigen-binding site represents minimal active derivable antibody...

Purpose: To evaluate the repeatability of a multispectral-based refractor in central and peripheral refraction measurement, to assess agreement such measurements with objective (OR) subjective (SR) patients myopia. Methods: A total 60 subjects were recruited this prospective research. Patients divided into three groups according refractive error. Next, parameters measured using multispectral tomography (MRT) before after cycloplegia. In addition, OR SR also performed. The intraobserver was...

Background: To determine the influence of magnitude treatment zone decentration on axial length (AL) elongation and to investigate association between paracentral corneal asymmetry orthokeratology (OK) lens decentration. Methods: This retrospective study involved 268 subjects (7–14 years) who wore OK lenses for one year. The parameters that reflected were recorded: toricity; Q value; anterior curvature; elevation values at 6-, 7-, 8-mm chords along horizontal meridian. relationships these...

To assess the current myopia prevalence rate and evaluate effect of sunshine duration on among primary school students in north south China.This prospective cross-sectional study pooled data from 9171 (grades 1 to 6) four cities China. National Geomatics Center China (NGCC) Meteorological Administration provided about altitude, latitude, longitude, average annual temperature, duration. Non-cycloplegic refraction was recorded, rates factors associated with were analyzed. Univariate...

We have determined the complete amino acid sequence of a tryptic Fc delta fragment generated from an intact human IgD (WAH); it is 226 residues long and includes second (C 2) third 3) constant domains chain. Comparison homology five immunoglobulin classes suggests that either delta-chain gene evolved alpha-chain soon after divergence mu-alpha common ancestor or ancestral distinct both gamma-epsilon ancestors. Comparative study using spatial model region indicates structure C 3 domain differs...

Background . The change in refraction caused by accommodation inevitably affects the peripheral defocus state and thus may influence effect of retinal myopic measures myopia control. This study investigated changes different retinas under cycloplegia to help improve Methods Fifty‐six eyes fifty‐six subjects were recruited for this prospective study. center retina refractions measured using multispectral refractive topography. divided into low‐to‐moderate group (range: −1.25 D −6.00 D) high...

We have determined the amino acid sequence of first constant (C) region domain (C delta 1) and hinge heavy chain human IgD WAH also adjacent COOH-terminal portion variable (V) region, including JH region. Together with Fc fragment already reported, this establishes complete C confirms presence three domains in IgD. Although CH1 five classes chains expected degree homology (approximately 30%), 1 mouse is less than that exhibited by other pairs chains. The has an unusual structure;...

To determine the biometry of anterior segment dimensions human eye on both horizontal and vertical meridians with extended scan depth optical coherence tomography (OCT) during accommodation.Twenty pre-presbyopic volunteers, aged between 24 30, were recruited. The ocular each subject was imaged using an OCT under non- 3.0 diopters (D) accommodative demands meridians. All images analyzed to yield following parameters: pupil diameter (PD), chamber (ACD), posterior surface curvatures crystalline...

To identify the novel mutation alleles in CYP1B1 gene of primary congenital glaucoma (PCG) patients at Shandong Province China, and investigate their correlation with glaucomatous features.The DNA from peripheral blood 13 50 ethnically matched healthy controls affiliated hospital Qingdao University were extracted. The coding region was amplified by PCR direct sequencing performed. Disease causing-variants analyzed comparing sequences structures wild type mutant proteins PyMOL software.Two...

Using a custom-developed segmentation algorithm, agreement of corneal epithelial thickness profile measurements between two spectral domain optical coherence tomography (SD-OCT) systems was assessed.Eighteen left eyes (18 subjects; mean±standard deviation; age, 23.2±0.9 years) were imaged twice on nonconsecutive days by custom-built ultra-high resolution OCT (UHR-OCT) system and commercial RTVue system. A algorithm based axial gradient information shortest path search developed to measure...

Objective: To test accuracy and repeatability of a software algorithm that performs automatic biometry the anterior segment human eye imaged with long scan depth optical coherence tomography (OCT). Methods: The ocular imaging was performed custom-built OCT. An including boundary segmentation, image registration, correction developed for fast reliable biometric measurements based on OCT images. segmentation mainly used gradient information images applied shortest path search dynamic...

To evaluate the anterior segment biometry of Tetraflex accommodating intraocular lens (AIOL) and contribution forward movement to amplitude accommodation (AMP).Patients who underwent phacoemulsification with implantation AIOLs control nonaccommodating lenses were imaged by custom-built, long scan depth spectral-domain optical coherence tomography at relaxed maximal accommodative states. Anterior was performed correlated clinical manifestation including AMP.Patients in group showed better...

To evaluate visual acuity, corneal astigmatism and higher-order aberrations (HOAs) after implantation of trifocal diffractive IOLs operated with either a steep-axis incision or 135° incision. This prospective study enrolled patients randomly assigned to different groups. According preoperative astigmatism, 101 eyes 77 were into group A1 (0 ~ 0.50 D) A2 (0.51 1.00 B1 B2 Visual followed-up for 3 months. Corneal in significantly decreased months surgery (P < 0.01) was lower than that 1 day, 2...

To compare the efficacy between two different silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy (T-PRK).In this randomized controlled trial, a total of 89 patients (178 eyes) who underwent T-PRK at Qingdao Eye Hospital from October to December 2019 were selected. One random eye wore Senofilcon A lens surgery, and other Balafilcon lens. Pain scores, uncorrected visual acuity (UCVA), spherical equivalent (SE), corneal epithelial healing status,...

Abstract We used an ultra-long scan depth optical coherence tomography (UL-OCT) system to investigate changes in axial biometry of pseudophakic eyes during pilocarpine- induced accommodation. The right from 25 healthy subjects (age range 49 84 years) with intraocular lens (IOL) were imaged twice the non-accommodative and accommodative states. A custom-built UL-OCT instrument whole eye. Then accommodation was by two drops 0.5% pilocarpine hydrochloride separated a 5-minute interval. Following...