A5101662100- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cardiac Ischemia and Reperfusion
- Esophageal and GI Pathology
- Intracranial Aneurysms: Treatment and Complications
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Mesenchymal stem cell research
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Anesthesia and Neurotoxicity Research
- Genetic Syndromes and Imprinting
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
- Circular RNAs in diseases
- Immune Response and Inflammation
- interferon and immune responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
University of South China
2025
West China Hospital of Sichuan University
2022-2025
Sichuan University
2022-2025
First Hospital of Jilin University
2010-2024
Jilin University
2010-2024
Southern Medical University
2024
Nanchang University
2024
Fujian Women and Children Hospital
2021-2022
First Affiliated Hospital of Xiamen University
2014-2022
Guangxi Medical University
2022
Patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) have poor prognosis. For these patients, treatment options are limited after first-line systemic therapy.In this open-label phase III clinical study, patients ESCC, whose tumor progressed treatment, were randomly assigned (1:1) to receive intravenous tislelizumab, an anti-programmed death protein 1 antibody, 200 mg every 3 weeks chemotherapy (investigator's choice of paclitaxel, docetaxel, irinotecan). The primary...
Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of clinical antineoplastic activity, but increased apoptosis has been implicated in its cardiotoxicity. Resveratrol (RES) was shown to harbour major health benefits diseases associated oxidative stress. In this study, we aimed determine the effect RES on DOX-induced myocardial mice. Male Balb/c mice were randomized one following four treatments: saline, RES, DOX, or plus DOX (10 each group). treatment markedly depressed cardiac...
Myocardial ischemia–reperfusion injury (MIRI), caused by the initial interruption and subsequent restoration of coronary artery blood, results in further damage to cardiac function, affecting prognosis patients with acute myocardial infarction. Ferroptosis is an iron-dependent, superoxide-driven, non-apoptotic form regulated cell death that involved pathogenesis MIRI. characterized accumulation lipid peroxides (LOOH) redox disequilibrium. Free iron ions can induce oxidative stress as a...
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease diabetes. Analysis data from recently published genome-wide association studies (GWAS) demonstrated that reduced-function polymorphisms the organic cation transporter, OCT1 (SLC22A1), are significantly higher total cholesterol, low-density lipoprotein (LDL) triglyceride (TG) levels an increased risk for type 2 diabetes...
Beiging of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment metabolic diseases through norepinephrine (NE)-mediated signaling pathways. Although previous studies report NE clearance mechanisms via SLC6A2 on sympathetic neurons or proinflammatory macrophages tissues (ATs), low catecholamine capacity may limit cleaning efficiency. Here, we that mouse organic cation transporter 3 (Oct3; Slc22a3) highly expressed WAT and displays greatest uptake...
To the Editor: Gastroscopy is considered to be main method for diagnosing gastric lesions.[1] But correctly different lesions under white light endoscopy (WLE) may challenging as morphological manifestations of are varied and some even subtle. Due uneven diagnostic levels across various regions scarcity experienced endoscopists, misdiagnosis missed diagnosis occur. In addition, endoscopists overwhelmed by heavy workloads, fatigue lead a further decline in performance, endoscopists. Recent...
Esophageal squamous cell carcinoma (ESCC) poses a significant global health challenge, necessitating early detection, timely diagnosis, and prompt treatment to improve patient outcomes. Endoscopic examination plays pivotal role in this regard. However, despite the availability of various endoscopic techniques, certain limitations can result missed or misdiagnosed ESCCs. Currently, artificial intelligence (AI)-assisted diagnosis has made strides addressing these improving ESCC precancerous...
The aim of the present study was to investigate protective function and underlying mechanism calcitonin gene-related peptide (CGRP) on cerebral ischemia/reperfusion damage in rats. Adult male Wistar rats were selected for establishment an injury model through application a middle artery occlusion. Animals randomly divided into 6 groups 24 animals. Drugs administered according design each group; animals CGRP, CGRP8-37, PD98059 SB20358. neurobehavioral scores rat ischemia group calculated....
// Yu-Hao Zhao 1 , Tie-Feng Ji 2 Qi Luo and Jin-Lu Yu Department of Neurosurgery, The First Hospital Jilin University, Changchun, P.R. China Radiology, Correspondence to: Yu, email: Luo, Keywords : long non-coding RNA H19, hippocampal neurons, diabetes mellitus, Wnt signaling pathway, streptozotocin, Pathology Section Received November 24, 2016 Accepted March 16, 2017 Published April 27, Abstract Defects in synaptic plasticity disorders memory learning are the central nervous system...
Myocardial injury caused by the myocardial ischaemia (MI) is still a troublesome condition in clinic, including apoptosis, oxidative stress and inflammation. Diosmetin inhibits cellular apoptosis inflammatory response enhances antioxidant activity. So, this study was designed to investigate cardioprotective effects of diosmetin on MI model neonatal rats. Forty Sprague Dawley (SD) rats 7 days old were randomly divided into five groups. Four groups received (50, 100, 200 mg/kg) or vehicle (MI...
Polydopamine nanoparticles are artificial melanin (MNPs) that show strong antioxidant activity. The effects of MNPs on the neuroprotection mesenchymal stem cells (MSCs) against hypoxic-ischemic injury and underlying mechanism have not yet been revealed. In this study, an oxygen-glucose deprivation (OGD)-injured neuron model was used to mimic neuronal in vitro. MSCs pretreated with then cocultured OGD-injured neurons were investigate potential elucidate mechanism. After coculturing...
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition 11β-HSD1 ameliorated multiple facets syndrome and attenuated atherosclerosis ApoE-/- mice. However, molecular mechanism underlying atheroprotective effect was not clear. In this study, we tested whether how affects vascular inflammation, a major culprit for its associated complications. mice were treated with an inhibitor various periods...
This study aimed to investigate the inhibitory roles of a polysaccharide extract from Inonotus obliquus on U251 human neurogliocytoma cells cultured in vitro. After administering I. cultivated vitro, methyl thiazolyl tetrazoliym assay was performed measure effects tumor cell proliferation. The expression apoptosis-related proteins Bcl-2 and caspase-3 were determined by Western blotting. Different concentrations (25, 50, 100, 200, 500 µg/mL) added at 24, 48, 72 hours. Methyl showed that...
Breast cancer is the malignant tumor with highest incidence rate at present, and its ranks first in female population. COL11A1 an important component of collagen XI considered to play role a variety connective tissue diseases. Recent studies have shown that associated occurrence development many kinds tumors. However, prognostic value breast correlation immune cell infiltration are not clear. In this paper, we reveal immune-related function through in-depth bioinformatics analysis. The...
Acute cerebral ischemia is a manifestation of vascular insufficiency and has high mortality. However, the therapy for acute still limited. This study aimed to investigate effect microRNA-381 (miR-381) on repair nerve injury in rats with after lymphatic blockage (CLB) by targeting leucine-rich repeat C4 protein (LRRC4) through Stromal cell-derived factor-1/CXC chemokine receptor-4 signaling pathway.Rat models CLB middle artery occlusion (MCAO) were established, 56 Wistar divided into sham,...
Cardiomyocytes can resist ischemia/reperfusion (I/R) injury through ischemic postconditioning (IPoC) which is repetitive ischemia induced during the onset of reperfusion. Myocardial preconditioning up-regulated protein 2 (MIP2) a member WD-40 family proteins, we previously showed that MIP2 was (IPC). As IPC and IPoC engaged similar molecular mechanisms in cardioprotection, this study aimed to elucidate whether contributed IPoC-mediated protection against I/R injury. The experiment conducted...
Cadmium (Cd) is an important nephrotoxic pollutant. To examine late effects on the kidney of individuals previously exposed to chronic Cd at very low levels, male Wistar rats were given 20 nmol/kg i.p. injections every other day for 4 weeks. At 20(th), 28(th), 36(th), 44(th) and 52(nd) week study, renal metal accumulation, morphology function examined. Immunochemical staining was performed detect 3-nitrotyrosine (3-NT) metallothionein (MT) expression, cell proliferation global DNA...
WD40 repeat proteins have a variety of functions, such as signal transduction, transcription regulation, cell cycle control, autophagy and apoptosis. WDR26 is novel protein up-regulated during myocardial cells ischemic preconditioning (IPC) but its role in apoptosis induced by oxidative stress subcellular localisation are not clear. So we investigated the expression rat ischaemia-reperfusion injury model H9c2 stimulated H(2)O(2). The results showed that can be located at mitochondria Then...
Background: An increase in pathogenic copy number variants (pCNVs) has been recognized to associate with fetal growth restriction (FGR). Here, we aim explore the application value of chromosomal microarray analysis (CMA) prenatal diagnosis FGR. Methods: Prenatal ultrasound was applied identify A total 149 pregnant women FGR were enrolled our study. All subjects underwent karyotype and CMA reveal abnormalities. Results: In this study, all successfully detected by analyses. Of these subjects,...