A5100606256- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Advanced Radiotherapy Techniques
- Heart Failure Treatment and Management
- Orthopedic Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Mycobacterium research and diagnosis
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Bone and Joint Diseases
- Hemophilia Treatment and Research
- Immune Cell Function and Interaction
- Natural Compounds in Disease Treatment
- Nuclear Receptors and Signaling
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
Peking University
2010-2025
Peking Union Medical College Hospital
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shanghai Jiao Tong University
2009-2024
Shanghai First People's Hospital
2024
Memorial Sloan Kettering Cancer Center
2024
Hunan Cancer Hospital
2023
Fifth Hospital of Shijiazhuang
2021-2023
Hebei Medical University
2021-2023
Tianjin Medical University
2022
Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, efficacy long-term β-blocker therapy in CABG after hospital discharge is uncertain.The study included 5926 consecutive who underwent and were discharged alive. The prevalence consistency use determined with without a history myocardial infarction (MI). β-Blockers always used 1280 (50.9%) 1642 (48.1%)...
The objective of this study was to compare the radiologic and clinical outcomes HURWA robotic-assisted total knee arthroplasty (TKA) those conventional TKA.A 150 patients were randomized into two groups - 73 77 underwent TKA TKA, respectively. Preoperative postoperative Western Ontario McMaster University Osteoarthritis Index (WOMAC) score, Hospital for Special Surgery (HSS) 36-item Short Form Health Survey (SF-36) Knee Society Score (KSS) range motion (ROM) obtained compared between these...
9114 Background: TROP2 (trophoblast cell surface antigen 2) is commonly overexpressed in non-small lung cancer (NSCLC) and associated with poor prognosis. SKB264 a novel anti-TROP2 ADC developed using sulfonyl pyrimidine-CL2A-carbonate linker to conjugate its payload, belotecan-derivative topoisomerase I inhibitor, achieve an average Drug-to-antibody Ratio (DAR) of 7.4. The design was more effective balance between stability circulation release the payload tumor cells. Here we report...
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide. However, mechanism underlying atonic PPH remains partially elucidated. Multi-omics revealed that differentially expressed proteins and metabolites were enriched in immune-inflammation pathway vaginal blood patients with PPH. There was a pro-inflammatory immune microenvironment primarily activated by M1 macrophages decidua PPH, which presented as increased tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8...
MicroRNAs (miRNAs) are short, single-stranded and non-coding RNAs, freely circulating in human plasma correlating with vary pathologies. In this study, we monitored early myocardial injury recovery after heart transplantation by detecting levels of muscle-specific miR-133a, miR-133b miR-208a.7 consecutive patients underwent Fuwai hospital 14 healthy controls were included our study. Peripheral vein blood was drawn from on the day just (day 0), 1st, 2nd, 3rd, 7th 14th respectively. Serum...
Conventional coronary angiography (CCA) has been considered as a gold standard for the diagnosis of artery diseases; however, its diagnostic accuracy is still unknown.Between July 2004 and December 2011, 97 patients underwent CCA within 15 days before heart transplantation in Fuwai hospital. A head-to-head comparison study was performed to examine compared with that pathological anatomy. As confirmed by anatomy, 44 (45.4%) had diseases. The patient-based evaluation showed area under...
Abstract Background This study aimed to evaluate the association of circular RNA La‐related RNA‐binding protein 4 (circ‐LARP4) with clinical features and prognosis in osteosarcoma patients, further explore its effect on chemosensitivity cells. Methods Seventy‐two patients Enneking stage IIA‐IIB who underwent resection were consecutively enrolled, then, tumor tissues non‐tumor obtained. Circ‐LARP4 tissue/non‐tumor tissue was detected by quantitative polymerase chain reaction. After circ‐LARP4...
To investigate the role of soluble programmed cell death ligand 1 (sPD-L1) protein in plasma patients with Peripheral T-cell lymphoma (PTCL).In total, 80 newly diagnosed PTCL and 75 healthy controls were enrolled. Levels sPD-L1 measured by ELISA at diagnosis after 3-8 courses chemotherapy. The expression PD-L1 tumor tissues from nine was also detected.sPD-L1 higher compared to subjects (P < 0.0001). Patients intermediate/high-risk disease group had a level than low-risk = 0.0003). Elevated...
Abstract Background Vacuum sealing drainage (VSD) and epidermal growth factor (EGF) both play an important role in the treatment of wounds. This study aims to explore effects combination VSD EGF on wound healing optimal concentration time EGF. Methods We tested proliferation migration capacity HaCaT L929 cells at different concentrations (0, 1, 5, 10, 100 ng/ml) action times (2, 30 min). A full-thickness skin defect model was established using male, 30-week-old Bama pigs. The experiment...
Sparse data exist regarding how clinician-assigned New York Heart Association (NYHA) class compares with heart failure (HF)-specific Kansas City Cardiomyopathy Questionnaire (KCCQ) in acute HF.To compare concordance between NYHA and KCCQ overall summary score (KCCQ-OS) HF investigate associations of changes KCCQ-OS long-term outcomes.In this cohort study, patients were enrolled from 52 hospitals China August 2016 May 2018. Among at admission 1 month, levels each scale categorized into 4...
Compatibility of hyaluronic acid hydrogel (HAH) and skeletal muscle myoblasts has been investigated for the first time in present paper. Skeletal were separated from skeletons rats incubated with a HAH-containing culture medium. Cell morphology, hydrophilicity cell adhesion HAH scaffold using optical microscopy, scanning electron Hoechest33258 fluorescent staining, immunocytochemistry method water adsorption rate measurement. It was found that at proper concentration (around 0.5%) acid,...
Despite great advances in treatment, 30-40% of patients with DLBCL undergo relapses. Patients a relapse within 1 year or beyond have distinct outcome. Few clinical characteristics and survival data the Chinese population been published. We aimed to define incidence features very early after front-line immunochemotherapy who may benefit greatly from emerging chimeric antigen receptor T-cell therapy. Data 564 were analyzed. Among 413 achieving first complete remission, 59 underwent relapses:...
Comprehensive genomic sequencing is becoming a critical component in the assessment of hematologic malignancies, with broad implications for patients’ management. In this context, unequivocally discriminating somatic from germline events challenging but greatly facilitated by matched analysis tumor:normal pairs samples. contrast to solid tumors, malignancies conventional sources normal control material (peripheral blood, buccal swabs, saliva) could be highly involved neoplastic process,...
Consolidation therapy improves the duration of response among patients with primary central nervous system lymphoma (PCNSL). Lenalidomide maintenance has shown encouraging results in older PCNSL. Herein, we performed a retrospective, single-center analysis to evaluate effect lenalidomide on newly-diagnosed
Diagnosis of intravascular large B-cell lymphoma (IVLBCL) is a challenge due to its heterogeneous clinical presentation and lack specific markers. This retrospective study investigated the utility circulating tumour DNA (ctDNA) sequencing for diagnosing IVLBCL analysing mutation landscape. A cohort 34 patients enrolled underwent plasma ctDNA targeted sequencing. The median concentration was 135.0 ng/mL, significantly higher than that in diffuse (DLBCL) controls. Correlations were found...
Neural remodeling after myocardial infarction (MI) may cause fatal ventricular arrhythmia. Schwann cells (SCs), which are important for neurogenesis, dramatically reduced MI. We investigated the feasibility of modifying nervous system regeneration MI and efficacy by it prevent arrhythmia following SC transplantation.Immediately creation MI, syngenic Lewis rats were randomized into cell transplantation (n=80) control groups (n=72). SCs isolated from sciatic nerves, 5×10(6) intramyocardially...