A5101399033- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- High Altitude and Hypoxia
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Cancer Research and Treatments
- Neuroscience and Neuropharmacology Research
- Protein Tyrosine Phosphatases
- Nerve injury and regeneration
- NF-κB Signaling Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Lipids, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Molecular Biology Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Rate Variability and Autonomic Control
- Viral Infectious Diseases and Gene Expression in Insects
Chinese Center For Disease Control and Prevention
2024-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2012-2024
Center for Disease Control
2024
Lanzhou University
2022-2024
Beijing Institute of Education
2008-2024
Capital Medical University
2014-2023
Institute of Physiology and Basic Medicine
2009-2023
Chinese Institute for Brain Research
2009-2022
Academy of Military Medical Sciences
2007-2022
First Affiliated Hospital of Xiamen University
2021
The molecular mechanisms governing acquired tumor resistance during radiotherapy remain to be elucidated. In breast cancer patients, overexpression of HER2 (human epidermal growth factor receptor 2) is correlated with aggressive and increased recurrence. the present study, we demonstrate that expression can induced by radiation in cells a low basal level HER2. Furthermore, HER2-postive tumors occur at much higher frequency recurrent invasive (59%) compared primary (41%). Interestingly,...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism meet the extra energy demands repair survive such genotoxic conditions. However, stress-induced adaptive metabolic alterations, especially in that radiotherapy, remain unresolved. In this study, we found CPT1 (Carnitine palmitoyl transferase I) CPT2 II), a pair of rate-limiting enzymes for mitochondrial fatty acid transportation, play critical role increasing oxidation (FAO) required...
A unique feature of cancer cells is to convert glucose into lactate produce cellular energy, even under the presence oxygen. Called aerobic glycolysis [The Warburg Effect] it has been extensively studied and concept in tumor generally accepted. However, not clear if fixed, or can be reversed, especially therapeutic stress conditions. Here, we report that mTOR, a critical regulator cell proliferation, relocated mitochondria, as result, enhances oxidative phosphorylation reduces glycolysis....
Oxygen is vital to maintain the normal functions of almost all organs, especially for brain which one heaviest oxygen consumers in body. The important roles on are not only reflected development, but also showed pathological processes many cerebral diseases. In current review, we summarized levels tissues tested by real-time measurements during embryonic and adult neurogenesis, diseases, or hyperbaric/hypobaric environment. concentration low fetal (0.076-7.6 mmHg) (11.4-53.2 mmHg), decreased...
One of the primary antioxidant enzymes, manganese-containing superoxide dismutase (MnSOD), has shown ability to reverse malignant phenotypes in a variety human tumor cells that are low or absent MnSOD expression. We have observed overexpression breast cancer MCF-7 inhibits growth both vitro and vivo. The signaling pathway underlying induced suppression is unknown. demonstrate here transcriptional DNA binding AP-1 NF-κB, but not SP-1, were inhibited (by 50%) cell line overexpressing MnSOD....
Abstract Neuroimaging methods have been employed to study cue‐reactivity‐induced neural correlates in the human brain. However, very few studies focused on characterizing dynamic responses factorial interactions between cues and subjects. Fifteen right‐handed heroin‐dependent subjects 12 age‐matched nondrug using participated this study. Cue‐reactivity paradigms were employed, while changes blood oxygenation level‐dependent (BOLD) signals acquired by functional MRI (fMRI). The fMRI datasets...
Manganese superoxide dismutase (MnSOD), a major antioxidant enzyme within the mitochondria, is responsible for detoxification of free radicals generated by cellular metabolism and environmental/therapeutic irradiation. Cell cycle-dependent kinase Cdk1, along with its regulatory partner CyclinB1, plays important roles in regulation cell cycle progression as well genotoxic stress response. Herein, we identified presence minimal Cdk1 phosphorylation consensus sequence ([S/T]-P; Ser106) human...
To investigate the expressional alternation of microRNAs (miRNA) during malignant transformation and development human glioma, we measured miRNA expression profile as well mRNA in normal neural stem cells (hNSCs) glioma (hGSCs). We found 116 up-regulated 62 down-regulated GSCs. On other hand, identified 1,372 down-regulated, 1,501 GSCs compared to those NSCs. then analyzed pathways predicted target genes miRNAs which differ significantly between NSCs using statistical enrichment methods....
Objectives The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to brain. aim of present study was investigate brain structural damage COPD. Design Retrospective case–control study. Patients with COPD and healthy volunteers were recruited. two groups matched age, gender educational background. Setting A hospital number communities: they are all located southern Fujian province, China. Participants 25 stable...
<h3>BACKGROUND AND PURPOSE:</h3> Decreased oxygen supply may cause neuronal damage in the brains of patients with COPD, which is manifested by clinical symptoms such as neuropsychological deficits and mood disorders. The aim present study was to investigate brain gray matter change COPD. <h3>MATERIALS METHODS:</h3> Using voxel-based morphometry based on high-resolution 3D T1-weighted MR images GM volume, we investigated 25 stable COPD matching healthy volunteers. A battery tests also...
Radiotherapy is of critical importance in the treatment breast cancer. However, not all patients derive therapeutic benefit and some cancers are resistant to treatment, thus evidenced with prospective distant metastatic spread local recurrence. In this study, we investigated potential effects all-trans retinoic acid (ATRA) on radiation-resistant cancer cells associated invasiveness. The MCF7/C6 gained radiation resistance after a long term fractionated ionizing were derived from human MCF7...
Understanding health system delay (HSD) in pulmonary tuberculosis (PTB) diagnosis aids tailoring interventions for case detection and curbing transmission. However, recent nationwide studies on HSD PTB have been scarce. This study assesses its risk factors China, taking into account the impact of COVID-19 epidemic. Patients diagnosed with between 2019 2022 were selected using a multistage stratified clustering method. A semi-structured questionnaire was employed to assess HSD, which defined...
Understanding the resilience of tuberculosis healthcare services (TB-HSs) is crucial for targeted reinforcement weak links and mitigation impact public health emergencies (PHEs). However, assessment systems in this domain are lacking. This study aims to construct a index system (RAIS) TB-HSs China. The following four-step design process was conducted: 1) establishing RAIS pool based on literature review, 2) designing an initial Donabedian's "structure-process-outcome" framework through...
The molecular mechanism by which tumor cells increase their resistance to therapeutic radiation remains be elucidated. We have previously reported that activation of nuclear factor-kappaB (NF-kappaB) is causally associated with the enhanced cell survival MCF+FIR derived from breast cancer MCF-7 after chronic exposure fractionated ionizing radiation. aim present study was reveal context NF-kappaB pathways in adaptive radioresistance. Using lines isolated populations, we found elevated...
Our recent study revealed a high correlation between the expression of hypoxia-inducible factor-1 (HIF-1) alpha and divalent metal transporter 1 (DMT1) in HepG2 cells treated with chemical or physical hypoxia. We therefore speculated that DMT1 might be one target genes HIF-1. Here, we characterized exon1B promoter region identified functional hypoxia response element (HRE, 5'-TCAGTACCTAACGTGGCGCCACGGC-3') harboring binding site for demonstrated hypoxia-dependent activation luciferase...
Surface enhanced Raman scattering (SERS) nanoparticles are an attractive alternative to fluorescent probes for biological labeling because of their photostability and multiplexing capabilities. However, nanoparticle size, shape, surface properties known affect nanoparticle-cell interactions. Other issues such as the formation a protein corona antibody multivalency interfere with nanoparticle-antibody conjugates. Hence, it is important consider these aspects in order validate conjugates live...
Abstract The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many human cancers, including chemoresistant and radioresistant breast cancer cells, but its functional contributions these settings are unclear. Here, we report that after cell irradiation, translocates into mitochondria, where it prevents apoptotic induction by limiting accumulation of phosphorylated active forms the stress kinase JNK. Increased levels mitochondrial irradiation occurred inner membrane space. Notably, survival...
Ciliary neurotrophic factor (CNTF) is primarily known for its important cellular effects within the nervous system. However, recent studies indicate that receptor can be highly expressed in denervated skeletal muscle. Here, we investigated direct effect of CNTF on myoblasts adult human. Surprisingly, found induced myogenic lineage-committed at a clonal level to dedifferentiate into multipotent progenitor cells—they not only could proliferate over 20 passages with expression absence specific...
NF-kappaB has been well documented to play a critical role in signaling cell stress reactions. The extracellular signal-regulated kinase (ERK) regulates proliferation and survival. GADD45beta is primary cycle element responsive activation anti-apoptotic responses. present study provides evidence demonstrating that NK-kappaB, ERK are co-activated by ionizing radiation (IR) pattern of mutually dependence increase Stress conditions generated human breast cancer MCF-7 cells the administration...