A5078614706- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hemophilia Treatment and Research
- Orthopedic Infections and Treatments
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- Anesthesia and Pain Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Tribology and Wear Analysis
- Spine and Intervertebral Disc Pathology
- Antiplatelet Therapy and Cardiovascular Diseases
- Circular RNAs in diseases
- Synthesis of β-Lactam Compounds
- Hip and Femur Fractures
- Mesenchymal stem cell research
- Telemedicine and Telehealth Implementation
- Soft tissue tumors and treatment
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Academy of Medical Sciences
2020-2024
Beijing Forestry University
2022
Creative Commons
2019
Tongji University
2013
Union Hospital
2010
Poly(methyl methacrylate) (PMMA) bone cement has been widely used in orthopedic surgeries including total hip/knee replacement, vertebral compression fracture treatment, and defect filling. However, aseptic loosening of the interface between PMMA often leads to failure. Hence, development modified that facilitates growth into is key reducing incidence loosening. In this study, MgAl-layered double hydroxide (LDH) microsheets (PMMA&LDH) with superior osseointegration performance synthesized....
Glucocorticoids play a pivotal role in the proliferation of osteoblasts, but underlying mechanism has not been successfully elucidated. In this report, we have investigated molecular which elucidates inhibitory effects dexamethasone on murine osteoblastic MC3T3-E1 cells. It was found that were largely attributed to apoptosis and G1 phase arrest. Both cell cycle arrest dependent glucocorticoid receptor (GR), as they abolished by GR blocker RU486 pre-treatment interference. accompanied with...
Patient follow-up is an essential part of hospital ward management. With the development deep learning algorithms, individual assignments might be completed by artificial intelligence (AI). We developed AI-assisted conversational agent that can simulate human voice and select appropriate time for quantitative, automatic, personalized patient follow-up. feedback information could collected converted into text data automatically.The primary objective this study was to compare...
Objective Total knee arthroplasty (TKA) is an established surgical technique and the standard treatment for degenerative joint diseases. However, severe pain after TKA makes it difficult many patients to perform early postoperative rehabilitation functional exercise, which might result in subsequent unsatisfactory recovery of function great reduction patients’ satisfaction quality life. Orthopaedic surgeons have tried a large variety analgesics analgesic modes relieve TKA. There are regimens...
To the Editor: Artificial joint replacement, most effective treatment for end-stage arthropathy of hip and knee caused by various reasons, has been popularly performed around world.[1] It was reported number total replacement case in United States 2017 1.1 million 2018 1.3 million.[2] And is increasing annually. With biggest population world, there a big volume procedures China. However, lack artificial annual data report China up-to-date. In this study, we intended to collect mainland...
Abstract Long noncoding RNAs (lncRNAs) are considered a novel class of regulatory factors in many diseases, but their biological function and the signaling pathway involved osteoarthritic (OA) remain unknown. To identify lncRNAs specifically expressed OA cartilage, expression cartilage was measured using an illumina sequencing platform. Furthermore, differentially transcripts uncertain coding potential (TUCPs) messenger (mRNAs) were identified. The colocated target genes possible role as...
The tumor microenvironment (TME), which is characterised by high H2O2 and glutathione (GSH) levels, low pH value hypoxia, imposes crucial influences on therapeutic outcomes. Rational design preparation of nanomaterial systems that are responsive to the intrinsic properties TME open a promising avenue towards tumor-specific treatment. Herein, CoMn-layered double hydroxide (CoMn-LDH) nanosheets were synthesized via bottom-up method followed surface modification with photosensitizer, chlorin e6...
Bioinert polymethylmethacrylate (PMMA) bone cement is the most conventional approach for quick fixation of orthopedic implant during hip replacement surgery. However, problems with loosening occur frequently and particularly under osteoporosis due to inadequate osteointegration between host bone. In order enhance ability PMMA cement, mineralized collagen (MC) was incorporated into (PMMA-MC) in current study. An improved wettability dynamic mechanical performance PMMA-MC demonstrated vitro,...
The present study aimed to identify microRNAs (miRNAs) from bone marrow mesenchymal stem cells (BMSCs) in a rat model of steroid-induced osteonecrosis the femoral head (ONFH) using Affymetrix GeneChip®. Following identification miRNAs, elucidate molecular mechanisms underlying steroid‑induced ONFH. A total six C57BL/6J mice were randomly divided into two groups, control and experimental groups (n=3 per group). group subcutaneously injected with 21 mg/kg methylprednisolone for 4 weeks, while...
Abstract Background Physical therapy has demonstrated efficacy in managing nonspecific low back pain (NLBP) among patients. Nevertheless, the prevalence of NLBP poses a challenge, as existing medical infrastructure may be insufficient to care for large patient population, particularly geographically remote regions. Telerehabilitation emerges promising method address this concern by offering deliver superior greater number patients with NLBP. Objective The purpose study is demonstrate...
Osteoarthritis (OA) is the utmost commonly arising joint disease. Knee condyles play an essential role during OA progression. Circular RNA (or circRNA) a novel kind of RNA, which, unlike well-known linear plays important regulatory in on basis previous research. In our study, expression circRNAs knee condyle was measured by illumine sequencing platform. A total 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, 21 target miRNAs, 2466...
Abstract The role of circular RNAs (circRNAs) in regulating cartilage homeostasis osteoarthritis (OA) has been reported. However, the regulatory mechanisms circRNAs OA synovium remains basically unidentified. current study intended to divulge expression profile and investigate possible molecular synovitis through an integrated bioinformatics analysis. A total 35 samples were collected, including 17 from patients with knee 18 controls. circRNA sequencing was then carried out on five as well...
This research investigated the mechanical properties and bioactivity of polymethylmethacrylate (PMMA) bone cement after addition nano-hydroxyapatite(HA) coated collagen (mineralized collagen, MC).The MC in different proportions were added to PMMA detect compressive strength, compression modulus, coagulation biosafety. The MC-PMMA was embedded into rabbits co-cultured with MG 63 cells exam tissue compatibility gene expression osteogenesis.15.0%(wt) impregnated significantly lowered modulus...
Monolayer magnesium-based layered double hydroxide nanosheets loaded with alendronate were fabricated, which showed unprecedented osteogenic differentiation and bone regeneration performance.
Objectives To evaluate the morphine-sparing effects of sequential treatment versus placebo in subjects undergoing total knee arthroplasty (TKA), on pain relief, inflammation control and functional rehabilitation after TKA safety. Design Double-blind, pragmatic, randomised, placebo-controlled trial. Setting Four tertiary hospitals China. Participants 246 consecutive patients who underwent elective unilateral because osteoarthritis (OA). Interventions Patients were randomised 1:1 to...
Abstract Introduction Patients with haemophilia are prone to haemophilic arthropathy (HA). For end‐stage HA, total knee arthroplasty (TKA) is an effective procedure. However, limited data were available regarding complications of TKA in HA patients. Aim To provide comprehensive comparisons among patients osteoarthritis (OA), rheumatoid arthritis (RA) or HA. Methods The present study was a single‐surgeon cohort including who underwent TKAs for OA, RA from January 1997 December 2017....