A5101527957- Geology and Paleoclimatology Research
- Marine and coastal ecosystems
- CAR-T cell therapy research
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Helicobacter pylori-related gastroenterology studies
- Virus-based gene therapy research
- Environmental and Agricultural Sciences
- Epigenetics and DNA Methylation
- Microfluidic and Capillary Electrophoresis Applications
- Intestinal and Peritoneal Adhesions
- Metabolism, Diabetes, and Cancer
- Coastal wetland ecosystem dynamics
- 3D Printing in Biomedical Research
- Complementary and Alternative Medicine Studies
- Cancer Mechanisms and Therapy
- Intraperitoneal and Appendiceal Malignancies
- Acupuncture Treatment Research Studies
- Oceanographic and Atmospheric Processes
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
First Affiliated Hospital of Zhengzhou University
2025
Henan Academy of Sciences
2025
Minhang District Central Hospital
2023-2025
Fudan University
2023-2025
Qingdao Institute of Marine Geology
2019-2021
Ministry of Natural Resources
2019-2021
China Geological Survey
2019
Qingdao National Laboratory for Marine Science and Technology
2019
Qinghai University
2012
Glucose deprivation inhibits T-cell metabolism and function. levels are low in the tumor microenvironment of solid tumors insufficient glucose uptake limits antitumor response T cells. Furthermore, restriction can contribute to failure chimeric antigen receptor (CAR-T) cell therapy for tumors. However, impact remains unknown CAR-T therapy. transporters were detected overexpressed The impacts on cells checked vitro vivo. significantly decreased activation, effector function, expansion....
Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion certain nutrients. This work demonstrates application fully automated culture control, monitoring, data processing system achieve significant productivity...
ABSTRACT Chronic atrophic gastritis (CAG) is a precancerous lesion characterised by gastric mucosal atrophy and inflammation. Identifying key molecular mechanisms potential therapeutic targets essential to improve patient outcomes. Key modules differentially expressed genes (DEGs) were recognised in the GSE153224 dataset using weighted gene co‐expression network analysis (WGCNA) examination of differential expression. IGFBP7 was identified as hub protein–protein interaction (PPI) expression...
Chemotherapy is a classical method of cancer treatment. Cisplatin-based chemotherapy traditional and essential therapeutic approach in gastric However, the development drug resistance during treatment major obstacle that limits their further application, molecular changes have occurred resistance. Here, we found Dickkopf-related protein 1 (DKK1) highly expressed related to poor prognosis patients through public database mining. Next, also identified DKK1 CDDP-resistant cell lines, supporting...
Eutrophication has caused drastic changes to the marine ecosystem of East China Sea during past decades. However, there is relatively sparse evidence historical changes, as well explicit effects climatic and anthropogenic activities on primary productivity coastal ecosystems. In this study, surface core sediments from Zhejiang-Fujian mud area, coast, were analyzed using bulk molecular biomarkers. The results showed that characterized by increased phytoplankton a fluctuant transition blooms...