A5101950112- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- Folate and B Vitamins Research
- Gastroesophageal reflux and treatments
- Bladder and Urothelial Cancer Treatments
- Diet, Metabolism, and Disease
- Fluoride Effects and Removal
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
- Cancer, Lipids, and Metabolism
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Infrared Thermography in Medicine
- Galectins and Cancer Biology
- Simulation-Based Education in Healthcare
- Diet and metabolism studies
- Sulfur Compounds in Biology
- Cancer Risks and Factors
Utah Valley University
2023
National Cancer Institute
1997-2017
Division of Cancer Epidemiology and Genetics
2005-2017
United States Department of Health and Human Services
2017
National Institutes of Health
1994-2017
QIMR Berghofer Medical Research Institute
2012
University of the Witwatersrand
2012
Tehran University of Medical Sciences
2012
Icahn School of Medicine at Mount Sinai
2012
German Cancer Research Center
2012
Previous studies have shown that oesophageal and gastric cancers are the most common causes of cancer death in Golestan Province, Iran. In 2001, we established Atrak Clinic, a referral clinic for gastrointestinal (GI) diseases Gonbad, major city eastern Golestan, which has permitted, first time this region, endoscopic localisation histologic examination upper GI cancers. Among initial 682 patients seen at 370 were confirmed histologically to cancer, including 223 (60%) squamous cell (ESCC),...
Background: In rodents, zinc deficiency potentiates the effects of certain nitrosamines that act as esophageal carcinogens. Studies association between and squamous cell carcinoma in humans have been hampered by plasma homeostasis, which obscures individual differences total stores, uncertainty regarding bioavailability when estimating dietary intake because phytate from whole grains effectively prohibits absorption. By using baseline tissue biopsy specimens collected a prospective...
We examined the relation between dietary fruit and vegetables, carotenoids vitamin intakes risk of bladder cancer among male smokers in a prospective cohort study. Over median 11 years, we followed 27 111 aged 50–69 years who were initially enrolled Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. During this period, 344 men developed cancer. All these had completed 276-food item questionnaire at baseline. Cox proportional hazards models used to estimate relative risks 95% confidence...
In a cohort of 29 584 residents Linxian, China, followed from 1985 to 2001, we conducted case–cohort study the magnitude association Helicobacter pylori seropositivity with cancer risk in random sample 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed non-cardia and entire (N=1050). Baseline serum was evaluated for IgG antibodies whole-cell CagA H. antigens by enzyme-linked immunosorbent assay. Risks both cancers were increased individuals...
Participants in the General Population Trial, a randomized nutrition intervention trial Linxian, China, who received combination of selenium, beta-carotene, and vitamin E supplements, had statistically significantly lower cancer mortality rates than those did not receive supplements. In current study, we used case-cohort design to examine association between pre-trial serum levels risks developing esophageal gastric cancers during trial. We measured alpha- gamma-tocopherol cholesterol 1072...
Helicobacter pylori carriage (i.e., persistent exposure to the organism without gastric epithelial cell invasion) is an established risk factor for noncardia cancer. However, its association with of cancer cardia controversial. Consequently, we designed this prospective, nested case-control study further explore subsite-specific risks associated H. seropositivity (a surrogate marker exposure).A total 99 patients cancer, 82 and 192 cancer-free subjects were selected from among participants (n...
Hu N (Department of Cell Biology, Cancer Institute, Chinese Academy Medical Sciences, Beijing, China), Dawsey S M, Wu Bonney G E, He L J, Han X Y, Fu M and Taylor P R. Familial aggregation oesophageal cancer in Xangcheng County. International Journal Epidemiology 1992; 21: 877–882 Oesophageal is the second most common cause death China particularly prevalent northern China. Genetic factors have been studied less than environmental aetiology this disease. This study was conducted to evaluate...
<h3>Objective:</h3> Low serum pepsinogen I (PGI) and low I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy. We aimed to prospectively test the association between PGI/II risks non-cardia adenocarcinoma, cardia oesophageal squamous cell carcinoma (OSCC). <h3>Design:</h3> Case–cohort study nested in a prospective cohort with over 15 years follow-up. <h3>Setting:</h3> Rural region People's Republic China. <h3>Subjects:</h3> Men women aged 40–69 at baseline. <h3>Main...
<h3>Background</h3> Cancers of the upper gastrointestinal tract remain a significant cause morbidity and mortality. Cysteine, known to be involved in myriad immuno-modulatory, anti-oxidant, anti-carcinogenic pathways, has not been investigated aetiology oesophageal or gastric cancers. To examine relationship between serum cysteine concentration risk these cancers we conducted nested case–cohort study within General Population Nutrition Intervention Trial Linxian, China. <h3>Methods</h3> 498...
This study was designed to investigate the role of duodenogastric reflux in genesis gastric stump carcinoma rat. Carcinoma not detected any 11 control animals and only one animal with a Roux diversion. In contrast seven 12 developed (p less than 0.01 p 0.05 respectively). order determine which fraction implicated malignant process, bile alone or pancreaticoduodenal secretions were studied. No carcinomas found alone, but 10 14 0.01). The findings confirm that is an important factor imply...
Linxian, China has some of the highest rates esophageal/gastric cardia cancer in world. In 1983, esophageal balloon cytology screening was performed 3 communes northern Linxian. Of participants, 10,066 with no evidence were followed prospectively for 7 1/2 years to evaluate ability initial cytologic diagnoses identify individuals at increased risk developing esophagus or gastric cardia. A total 747 incident cases and 322 deaths due these tumors identified during follow-up period used this...
In November 1977, an enzyme-linked immunosorbent assay for detecting rotavirus antigen was introduced in the laboratory of a rural treatment centre Bangladesh. During next 40 days without other pathogens found stools 216 (45%) 480 children under age 5 years who visited with gastrointestinal illness. 188 (87%) these were treated oral rehydration alone, using solution currently recommended by World Health Organisation, while 28 (13%) also required some intravenous rehydration; there no deaths....
Previously, we observed strong positive associations between circulating concentrations of free testosterone and dihydrotestosterone (DHT) in relation to Barrett's esophagus a US male military population. To replicate these findings, conducted second study sex steroid hormones the Factors Influencing Barrett/Adenocarcinoma Relationship (FINBAR) Study based Northern Ireland Ireland. We used mass spectrometry quantitate EDTA plasma nine ELISA hormone-binding globulin 177 cases 185 general...
BACKGROUND: Immersive, realistic, and low-risk training has long been ideal for skill-based disciplines such as surgery. Recent advances in virtual reality technology have led to development of surgical software with the goal provide experience without risk. The aim this review is summarize current data reality-based orthopaedic surgery evaluate how beneficial may become educational circumstances. METHODS: A literature was completed analyzing eight randomized controlled trials between 2019...