Andrew A. Adjei
A5038612113- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Malaria Research and Control
- Genetic Associations and Epidemiology
- Mosquito-borne diseases and control
- Parasitic Infections and Diagnostics
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Hemoglobinopathies and Related Disorders
- Clostridium difficile and Clostridium perfringens research
- Iron Metabolism and Disorders
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS Research and Interventions
- Cancer Treatment and Pharmacology
- Fatty Acid Research and Health
- HIV, Drug Use, Sexual Risk
- Clinical Nutrition and Gastroenterology
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Complement system in diseases
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
University of Ghana
2016-2025
Korle Bu Teaching Hospital
2013-2024
Komfo Anokye Teaching Hospital
2016-2024
Dana-Farber Cancer Institute
2018-2022
Beth Israel Deaconess Medical Center
2018
Mayo Clinic in Arizona
1999-2018
Mayo Clinic
2001-2017
Roswell Park Comprehensive Cancer Center
2017
Ohio University
2017
University of Arizona
1999-2016
Background —It is well established that glutamine supplemented elemental diets result in less severe intestinal damage experimental colitis. However, few studies have examined the mode of action reducing damage. Aims— To examine effects on potent inflammatory cytokines interleukin 8 (IL-8) and tumour necrosis factor α (TNF-α) trinitrobenzene sulphonic acid (TNBS) induced colitis which presents with both acute chronic features ulcerative Methods— Sprague-Dawley rats were randomised into three...
Abstract Background Plasmodium falciparum can cause a diffuse encephalopathy known as cerebral malaria (CM), major contributor to associated mortality. Despite treatment, mortality due CM be high 30% while 10% of survivors the disease may experience short- and long-term neurological complications. The pathogenesis other forms severe is multi-factorial appear involve cytokine chemokine homeostasis, inflammation vascular injury/repair. Identification prognostic markers that predict severity...
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 prostate cancer. In this study, we conducted fine mapping of the (127.8–128.8Mb) in search novel associations with common and rare variation 4853 cancer case patients 4678 control subjects African ancestry. All statistical tests were two-sided. We identified three independent at P values less than 5.00×10 –8 , all which replicated studies from Ghana Uganda (combined sample = 5869 patients, 5615 subjects;...
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This harbors the TERT and CLPTM1L genes; former encodes catalytic subunit telomerase reverse transcriptase latter may play role in apoptosis. To investigate further genetic architecture common susceptibility this region, we conducted an agnostic subset-based meta-analysis (association analysis based subsets) across six 34 248 cases 45 036...
Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study 12,518 cases, we identify two loci associated Gleason score, pathological measure aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49 × 10−9) rs78943174 3q26.31 (NAALADL2, P=4.18 10−8). stratified case–control...
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a zoonotic virus transmitted by Ixodid ticks and causes hemorrhagic fever (CCHF) disease in humans with up to 50 % mortality rate.Freshly slaughtered livestock at the Kumasi abattoir Ashanti Region of Ghana were examined for presence once month over 6-month period from May November 2011. The grouped into pools species, sex, animal source. CCHFV was detected using reverse transcription PCR. Blood samples collected enrolled workers initiation,...
Abstract Background Human herpesvirus 8 (HHV-8), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are prevalent in Africa, but less common elsewhere the modes of transmission still subject to debate. Generally, they rarely cause disease immunocompetent host highly oncogenic when associated with immunosuppression. Although high prevalence HHV-8, CMV EBV has been well documented such data sparse from Ghana. Methods Serum samples 3275 HIV-seronegative healthy blood donors 250 HIV-AIDS...
Prisons are known to be high-risk environments for the spread of bloodborne and sexually transmitted infections. Prison officers considered have an intermittent exposure potential infectious diseases on job, however there has been no studies prevalence these infections in prison Ghana.A national multicenter cross-sectional study was undertaken correlates human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), syphilis sample inmates from eight ten regional central prisons Ghana. A...
Although the high prevalence of blood-borne viral infections and syphilis in correctional facilities has been well documented globally, such data are sparse from Africa, there no Ghana. This study sought to estimate human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV) among prison inmates officers at prisons Nsawan Accra, Prisoners 3 46 Ghana were surveyed May 2004 2005. Subjects voluntarily completed a risk-factor questionnaire provided blood specimens for unlinked anonymous...
In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36% healthy receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We the hypothesis that asymptomatic HRP II expressed a unique Th1 and Th2 phenotype differs from controls. Plasma (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>15</mml:mn></mml:math>)...
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates prostate cancer in men African descent, much what is known about genetics comes from populations European descent. To understand how genetic predictions perform different we evaluated test characteristics PRS three previous using data UK Biobank a novel dataset 1298 cases 1333 controls...
Although the roles played by systemic tumour necrosis factor (TNF) and interleukin 1β (IL-1β), their upregulation of intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1) E-selectin, in pathogenesis human cerebral malaria (CM) are well established, role local cytokine release, brain, remains unclear. Immunohistochemistry was therefore used to compare expression ICAM-1, VCAM-1, IL-1β, TNF transforming growth β (TGF-β) at light-microscope level, cryostat sections cerebral,...
Hepatitis E virus (HEV) is highly endemic in several African countries with high mortality rate among pregnant women. The prevalence of antibodies to HEV Ghana not known. Therefore we evaluated the anti-HEV IgG and IgM women seen between months January May, 2008 at Obstetrics Gynaecology Department, Korle-Bu Teaching Hospital, Accra, Ghana. One hundred fifty-seven provided blood samples for unlinked anonymous testing presence HEV. median age participants was 28.89 ± 5.76 years (range 13–42...
Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal and fetal mortality. This study determines pregnancy outcomes among women SCD delivering at Korle-Bu Teaching Hospital, Accra, Ghana. Nine hundred sixty (960) medical records pregnant (131 HbSS, 112 HbSC, 717 comparison group) from 2007 to 2008 were reviewed. The HbSS eclampsia (adjusted odds ratio [AOR] = 10.56, 95% confidence interval [CI] 3.60–30.96, P < 0.001), intrauterine growth restriction...
To our knowledge the reasons for high rates of prostate cancer in black American men are unknown. Genetic and lifestyle factors have been implicated. Better understanding West African would help clarify why such since groups share genetic ancestry yet different lifestyles screening practices. estimate burden we performed a population based study with biopsy confirmation Ghana.
Abstract Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial for prostate cancer (PrCa), their functional effects on remain largely unknown. Here we use genotype data from 59,089 men European and African American ancestries combined with cell-type-specific epigenetic to build a genomic atlas single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences between variants prostate-relevant marks defined normal...