A5070943733- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Mosquito-borne diseases and control
- Iron Metabolism and Disorders
- Trypanosoma species research and implications
- Complement system in diseases
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Health and Medical Research Impacts
- Diversity and Career in Medicine
- Child Nutrition and Water Access
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Global Maternal and Child Health
- Mentoring and Academic Development
- Insect symbiosis and bacterial influences
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Bone and Joint Diseases
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Kruppel-like factors research
- Immune Response and Inflammation
Morehouse School of Medicine
2016-2025
Beth Israel Deaconess Medical Center
2019
Korle Bu Teaching Hospital
2008-2017
University of Ghana
2008-2017
Bipar
2016
Howard University
2008-2012
University of Mississippi Medical Center
1999-2009
Centers for Disease Control and Prevention
2009
National Center for Infectious Diseases
2009
National Institute of Malaria Research
2008
The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC family which binds to CXCR3 receptor exert its biological effects. CXCL10 involved in chemotaxis, induction apoptosis, regulation cell growth and mediation angiostatic associated with variety human diseases including infectious diseases, chronic inflammation, immune dysfuntion, tumor development, metastasis dissemination. More importantly, has been identified as major marker mediating disease severity may be...
Abstract Background Plasmodium falciparum can cause a diffuse encephalopathy known as cerebral malaria (CM), major contributor to associated mortality. Despite treatment, mortality due CM be high 30% while 10% of survivors the disease may experience short- and long-term neurological complications. The pathogenesis other forms severe is multi-factorial appear involve cytokine chemokine homeostasis, inflammation vascular injury/repair. Identification prognostic markers that predict severity...
Abstract Background Plasmodium falciparum in a subset of patients can lead to cerebral malaria (CM), major contributor malaria-associated mortality. Despite treatment, CM mortality be as high 30%, while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis is mediated by alterations cytokine chemokine homeostasis, inflammation well vascular injury repair processes although their roles are not fully understood. hypothesis for this study...
Effective mentorship is critical to the success of early stage investigators, and has been linked enhanced mentee productivity, self-efficacy, career satisfaction. The mission National Research Mentoring Network (NRMN) provide all trainees across biomedical, behavioral, clinical, social sciences with evidence-based professional development programming that emphasizes benefits challenges diversity, inclusivity, culture within mentoring relationships, more broadly research workforce. purpose...
Both malaria and intestinal helminths are endemic in sub-Saharan Africa, their co-infection occurs commonly. This cross-sectional study assessed the prevalence of helminth a sample > 700 pregnant women Ghana identified risk factors for co-infection. The infection, infection(s), was 36.3%, 25.7%, 16.6%, respectively. Women with infection(s) were 4.8 times more likely to have infection. Young age, low income, being single, primigravid each associated increased odds These associations...
In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36% healthy receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We the hypothesis that asymptomatic HRP II expressed a unique Th1 and Th2 phenotype differs from controls. Plasma (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>15</mml:mn></mml:math>)...
More than half a century after the discovery of molecular basis Sickle Cell Disease (SCD), causes phenotypic heterogeneity disease remain unclear. This manifests with different clinical outcomes such as stroke, vaso-occlusive episodes, acute chest syndrome, avascular necrosis, leg ulcers, priapism and retinopathy. These cannot be explained by single mutation in beta-globin gene alone but may attributed to genetic modifiers environmental effects. Recent advances post human genome sequence era...
Plasmodium falciparum in a subset of patients can lead to diffuse encephalopathy known as cerebral malaria (CM). Despite treatment, mortality caused by CM be high 30% while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis involves alterations cytokine chemokine expression, local inflammation, vascular injury repair processes. These diverse factors have limited rate discovery prognostic predictors fatal CM. Identification reliable...
Plasmodium falciparum in a subset of patients can lead to diffuse encephalopathy known as cerebral malaria (CM). Despite treatment, mortality caused by CM be high 30% while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis involves alterations cytokine chemokine expression, local inflammation, vascular injury repair processes. These diverse factors have limited rate discovery prognostic predictors fatal CM. Identification reliable...
Sickle cell anemia (HbSS) includes chronic inflammation, but the origin is unclear. We hypothesized that in stable HbSS patients inflammation was associated with hypermetabolism. compared selected hypermetabolic and key Immuno-modulator indicators versus control children examined associations between measures of hypermetabolism inflammation. Twelve fasting asymptomatic 6–12 years 9 controls matched for age, gender fat mass (FM) were studied. Proportional reticulocyte count (retic%) resting...
Abstract Purpose: Metastasis is responsible for most cancer-related deaths; hence, therapies designed to minimize metastasis are greatly needed. The precise cellular and molecular mechanisms used by cancer cells not fully understood; however, the metastatic spread of neoplastic probably related ability these migrate, invade, home, survive locally. migration tumor shares many similarities with leukocyte trafficking, which regulated chemokine receptor–ligand interactions. current study...
Although the roles played by systemic tumour necrosis factor (TNF) and interleukin 1β (IL-1β), their upregulation of intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1) E-selectin, in pathogenesis human cerebral malaria (CM) are well established, role local cytokine release, brain, remains unclear. Immunohistochemistry was therefore used to compare expression ICAM-1, VCAM-1, IL-1β, TNF transforming growth β (TGF-β) at light-microscope level, cryostat sections cerebral,...
Current approaches to the treatment of ovarian cancer are limited because development resistance chemotherapy. Prohibitin (Phb1) is a possible candidate protein that contributes drug resistance, which could be targeted in neoplastic cells. Phb1 highly conserved associated with block G0/G1 phase cell cycle and also survival. Our study was designed determine role regulating cellular growth apoptosis results showed content differentially overexpressed papillary serous carcinoma endometrioid...
Abstract Background The mechanisms underlying the pathogenesis of cerebral malaria (CM) syndrome are not well understood. Previous studies have shown a strong association inflammatory chemokines, apoptotic markers and angiogenic molecules with CM associated mortality. Recognizing importance angiopoietins (ANG) in CM, retrospective investigation was carried out hospital cohort patients Plasmodium infection central India to determine if these factors could be suitable severity. Methods...
Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal and fetal mortality. This study determines pregnancy outcomes among women SCD delivering at Korle-Bu Teaching Hospital, Accra, Ghana. Nine hundred sixty (960) medical records pregnant (131 HbSS, 112 HbSC, 717 comparison group) from 2007 to 2008 were reviewed. The HbSS eclampsia (adjusted odds ratio [AOR] = 10.56, 95% confidence interval [CI] 3.60–30.96, P < 0.001), intrauterine growth restriction...
Despite appropriate anti-malarial treatment, cerebral malaria (CM)-associated mortalities remain as high 30%. Thus, adjunctive therapies are urgently needed to prevent or reduce such mortalities. Overproduction of CXCL10 in a subset CM patients has been shown be tightly associated with fatal human CM. Mice deleted gene partially protected against experimental (ECM) mortality indicating the importance pathogenesis However, direct effect increased production on brain cells is unknown. We...
Abstract Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium falciparum infection, has 20–30% mortality rate and predominantly affects African children. The mechanisms mediating HCM-associated brain injury are difficult to study in human subjects, highlighting the urgent need for non-invasive ex vivo models. HCM elevates systemic levels of free heme, which damages blood-brain barrier neurons distinct regions brain. We determined effects heme on induced...
Kidney disorders significantly contribute to morbidity and mortality in sickle cell disease (SCD). Acute kidney injury (AKI), a major risk factor for chronic (CKD), often arises from intravascular hemolysis, where plasma cell-free heme drives AKI through inflammatory oxidative stress mechanisms. Hydroxyurea (HU), well-established SCD-modifying therapy, improves clinical outcomes, but its effects on systemic mediators of remain underexplored. This study evaluated HU’s impact heme,...
The effectiveness of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) against malaria and anemia is unclear because the spread SP-resistant Plasmodium falciparum . This study evaluates IPTp-SP among pregnant women attending antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana. A cross-sectional comparing prevalence using non-IPTp-SP users was conducted June–August 2009. total 363 (202 IPTp 161 non-IPTp users) were recruited. 15.3% had...
Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Up to 40% of women attending a prenatal clinic Africa may be anemic. In cross-sectional study 755 pregnant women, Aflatoxin B(1)-lysine adducts (AF-ALB) levels were determined by high-performance liquid chromatography. Participants divided into quartiles "low," "moderate," "high," and "very high." Anemia was defined as hemoglobin < 11 g/dL. Logistic regression used examine the association...