A5049786082- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Child Nutrition and Water Access
- Complement system in diseases
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
Morehouse School of Medicine
2019-2022
Abstract Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium falciparum infection, has 20–30% mortality rate and predominantly affects African children. The mechanisms mediating HCM-associated brain injury are difficult to study in human subjects, highlighting the urgent need for non-invasive ex vivo models. HCM elevates systemic levels of free heme, which damages blood-brain barrier neurons distinct regions brain. We determined effects heme on induced...
Human cerebral malaria (HCM) is a severe complication of
Stroke, or cerebral infarction, is one of the most serious complications sickle cell anemia (SCA) in childhood, potentially leading to impaired development and life-long physical cognitive disabilities. About ten children with SCA are at risk for developing overt stroke an additional 25% may develop silent infarcts. This largely due underlying injury caused by chronic ischemia vascular insult associated SCA. We previously identified two elevated markers injury, plasma brain-derived...
In malaria endemic countries, anemia in pregnant women occurs as a result of erythrocyte destruction by Plasmodium infections and other causes including malnutrition. Iron supplementation is recommended treatment iron-deficiency anemia. Erythrocyte results increased release cytotoxic free heme that scavenged haptoglobin (Hp), hemopexin (Hx) oxygenase-1 (HO-1). Paradoxically, iron has been reported to enhance parasitemia increase levels heme. The relationship between heme, scavengers, birth...